Results 41 to 50 of about 236,506 (251)

The story of my life into and through the science of photosynthesis: a personal perspective

Photosynthetica
I present here the story of my personal and scientific life. I provide information on my parents, my childhood, schooling, education at the Wageningen Agricultural University, and the work for my PhD degree on the action of some herbicides on ...
J.J.S. VAN RENSEN
doaj   +1 more source

Carbonic Anhydrases and Metabolism

Metabolites, 2018
Although the role of carbonic anhydrases (CAs, EC 4.2.1.1) in metabolism is well-established, pharmacological applications of this phenomenon started to be considered only recently.
Claudiu T. Supuran
doaj   +1 more source

Functional Blood‐Brain Barrier Crossing by Biomimetic M13 Phage Vectors for Targeted Neuronal Delivery

Advanced Healthcare Materials, EarlyView.
This study investigates the M13 bacteriophage as a biomimetic nanovector capable of crossing in vitro models of the blood–brain barrier. By exploiting peculiar transcellular pathways, M13 avoids lysosomal degradation and preserves its structural integrity and functionality.
Silvia Vercellino, Lucia Pappagallo, Francesca De Chirico, Luca Boselli, Hazem Ahmed, Luca Spagnoletti, Giovanni Pittaluga, Paolo Emidio Costantini, Matteo Calvaresi, Pier Paolo Pompa, Alberto Danielli, Fabio Benfenati, Valentina Castagnola   +12 more
wiley   +1 more source

Critical role of bicarbonate and bicarbonate transporters in cardiac function

World Journal of Biological Chemistry, 2014
Bicarbonate is one of the major anions in mammalian tissues and extracellular fluids. Along with accompanying H(+), HCO3 (-) is generated from CO2 and H2O, either spontaneously or via the catalytic activity of carbonic anhydrase. It serves as a component of the major buffer system, thereby playing a critical role in pH homeostasis. Bicarbonate can also
Hong-Sheng, Wang, Yamei, Chen, Kanimozhi, Vairamani, Gary E, Shull   +3 more
openaire   +2 more sources

Affinity‐Tuned Albumin Hitchhiking Extends the Bioorthogonal Capture Window in Pretargeting Radiotheranostics

Advanced Healthcare Materials, EarlyView.
Pharmacokinetic engineering of clickable radioligands was achieved via albumin hitchhiking approach within a pretargeted radiotheranostics delivery platform. This approach reduced rapid renal elimination, expanded bioorthogonal capture window, boosted tumor uptake by ∼3.5‐fold, and improved the tumor‐to‐liver ratio by ∼6‐fold.
Xie He, Nicholas L. Fletcher, Gayathri R. Ediriweera, Yifei Zhu, James Humphries, Christopher B. Howard, Jiazheng Wang, Craig A. Bell, Kristian Kempe, Kristofer J. Thurecht   +9 more
wiley   +1 more source

Bioorthogonal Photoactivation of 2‐Nitrobenzyl Caged Doxorubicin Anticancer Prodrugs on Gold Nanostars

Advanced Materials, EarlyView.
Bioorthogonal chemistry was applied to intracellularly photoactivate Doxorubicin (Dox) using gold nanostars (AuNSt) and near‐infrared (NIR) light. Two prodrugs were used: one photoactivatable, masked with 2‐nitrobenzyl carbamate (proDox1) and another photolabile, masked with 2‐nitrobenzyl diol (proDox2), which was attached to the AuNSt surface.
Juan José Esteve‐Moreno, Andrea Escudero, Oscar Ferreira Silvestre, José Manuel Terrés, Mónica Gorbe, Eva Garrido, Carlos Renero‐Lecuna, Judith Langer, María Alfonso, Javier Ibañez, Félix Sancenón, Roberto Cao‐Milán, Luis M. Liz‐Marzán, Alba García‐Fernández, Andy Hernández‐Montoto, Ramón Martínez‐Máñez   +15 more
wiley   +1 more source

Criopreservação do sêmen de curimba (Prochilodus lineatus) mediante adição de diferentes diluidores, ativadores e crioprotetores Cryopreservation of curimba (Prochilodus lineatus) semen after addition of different diluters, activators and cryoprotectants

Revista Brasileira de Zootecnia, 2007
Amostras de sêmen de cinco espécimes de Prochilodus lineatus (Valencienes, 1847) foram utilizadas para avaliação dos efeitos tóxicos e crioprotetores de seis soluções à base de BTS (Beltsville Thawing Solution®) 4,5% enriquecidas com metanol e DMSO nas ...
Luis David Solis Murgas, Aléssio Batista Miliorini, Rilke Tadeu Fonseca de Freitas, Gilmara Junqueira Machado Pereira   +3 more
doaj   +1 more source

Thermally Modulated Metasurface Sensor for Dynamic and Time‐Resolved Isolation of Extracellular Vesicles

Advanced Materials, EarlyView.
A thermally adaptive plasmonic metasurface, functionalized with poly(N‐isopropylacrylamide) (PNIPAM) and anti‐CD63 antibodies, enables precise, on‐demand capture and release of extracellular vesicles (EVs). Delivering high recovery, improved purity, and intact vesicle structure, the platform offers a versatile, label‐free solution for real‐time EV ...
Beyza Nur Kucuk, Eylul Gulsen Yilmaz, Yusuf Aslan, Emre Ece, Özgecan Erdem, Murat Alp Gungen, Bengi Özgün Öztürk, Fatih Inci   +7 more
wiley   +1 more source

ANHIDRASA CARBÓNICA DE Plasmodium falciparum: UN BLANCO ÚTIL PARA EL DISEÑO DE MEDICAMENTOS ANTIMALÁRICOS Y COMPUESTOS BLOQUEADORES DE LA TRANSMISIÓN DE MALARIA CARBONIC ANHYDRASE IN Plasmodium falciparum: A USEFUL TARGET FOR ANTIMALARIAL DRUG DESIGNING AND MALARIA BLOCKING TRANSMISSION COMPOUNDS

Vitae, 2010
La anhidrasa carbónica es una metaloenzima que cataliza la conversión reversible del CO2 a bicarbonato, un componente metabólico indispensable para la síntesis de pirimidinas de novo por Plasmodium spp y los procesos de exflagelación llevados a cabo por ...
Carlos D AGUDELO R, María CORENA-McLeod, Sara M ROBLEDO R   +2 more
doaj  

CO₂/HCO₃⁻ Accelerates Iron Reduction through Phenolic Compounds

mBio, 2020
Iron is a vital mineral for almost all living organisms and has a pivotal role in central metabolism. Despite its great abundance on earth, the accessibility for microorganisms is often limited, because poorly soluble ferric iron (Fe3+) is the ...
Felix Müller, Johanna Rapp, Anna-Lena Hacker, André Feith, Ralf Takors, Bastian Blombach   +5 more
doaj   +1 more source