Results 61 to 70 of about 236,506 (251)

Light‐Activatable Nitric Oxide Release via Intramolecular Electron Transfer for Tumor Pyroptosis Induction

Advanced Science, EarlyView.
This work proposes a novel strategy to fabricate unimolecular pyroptosis photoinitiators activated by deep‐red light at low light doses. It relies on a photosensitization mechanism to trigger nitric oxide (NO) release from benzisothiadiazole‐based N‐nitrosanilines without modification of nitro moieties, thereby boosting pyroptosis‐mediated ...
Chuangxin Zhang, Ruipeng Li, Yunxia Wang, Feng Liu, Liheng Feng   +4 more
wiley   +1 more source

Harnessing MDM2‐Mediated Targeted Degradation of Transcriptional and Epigenetic Machinery to Disrupt Oncogenic Addictions in Pediatric Sarcoma

Advanced Science, EarlyView.
MDM2 dependency in pediatric sarcomas is driven by a novel p53‐independent oncogenic cistrome alongside canonical p53 pathway suppression. This study introduces MDM2‐recruiting transcriptional and epigenetic machinery degraders (MDM2‐TEMADs) as a novel precision oncology modality.
Jiawei Zhou, Xian Guan, Nan Li, Ying Zhang, Long Xie, Xingze Huang, Zhipeng Zhu, Zhuolin Ren, Xiaoyan Yu, Hanjun Guo, Yuanfang Wu, Lin Ma, Suya Zheng, Jingyao Zhang, Jiyang Liu, Victor Kuanmin Lee, Wenhao Chen, H. Phillip Koeffler, Jinhu Wang, Xin Han, Ye Chen, Liang Xu   +21 more
wiley   +1 more source

Optimization of Culture Conditions for High Cell Productivity and Astaxanthin Accumulation in Vietnam’s Green Microalgae Haematococcus pluvialis HB and a Neuroprotective Activity of Its Astaxanthin

Bioengineering
Background: Haematococcus pluvialis, a green microalga, is a rich source of natural astaxanthin and a potent antioxidant with high commercial value. This study investigates the biological characteristics and potential of H. pluvialis HB isolated from Hoa
Nguyen Cam Ha, Luu Thi Tam, Hoang Thi Minh Hien, Ngo Thi Hoai Thu, Dang Diem Hong, Le Thi Thom   +5 more
doaj   +1 more source

Differential Responses of Two Lactuca sativa Varieties to Bicarbonate-Induced Iron Deficiency [PDF]

Journal of Stress Physiology & Biochemistry, 2013
Iron chlorosis induced by bicarbonate is very common in calcareous soils, where bicarbonate (HCO3-) ions are present at high concentrations. In this study, morpho-physiological and biochemical responses of two Lactuca sativa varieties ...
Mohamed Chebbi, Najoua Msilini, Thouraya Amdouni, Zeineb Ouerghi   +3 more
doaj  

Insights Into CO2 Loss, pH Effects, and Tafel Kinetics in Ni Single Atom‐Driven Bicarbonate Electroreduction

Advanced Science, EarlyView.
Selective CO formation in bicarbonate electrolysis is achieved by retaining reactive CO2 and tuning pH, while the competing hydrogen evolution reaction occurs at the interface. The rate‐determining step couples the chemical equilibrium of bicarbonate/CO2 with electrochemical charge transfer, offering insight into optimizing reaction conditions for ...
Lin Li, Yi‐Jie Kong, Ting Zhang, Xu Han, Kristine Aalestrup, Steen Uttrup Pedersen, Xin‐Ming Hu, Kim Daasbjerg   +7 more
wiley   +1 more source

Acetazolamide and human carbonic anhydrases: retrospect, review and discussion of an intimate relationship

Journal of Enzyme Inhibition and Medicinal Chemistry
Acetazolamide (AZM) is a strong pharmacological sulphonamide-type (R-SO2-NH2, pKa 7.2) inhibitor of the activity of several carbonic anhydrase (CA) isoforms, notably of renal CA II (Ki, 12 nM) and CA IV (Ki, 74 nM).
Dimitrios Tsikas
doaj   +1 more source

Estimating the Relationship between Serum Electrolytes and COVID-19: A systematic Review and Meta-Analysis

Journal of Mazandaran University of Medical Sciences, 2022
Background and purpose: There are controversies on the association between electrolytes and Coronavirus disease 2019 (COVID-19) and its severity. Studies on these issues may help in resolving ambiguities.
Reza Alizadeh-Navaei, Ghazal Mohseni, Keivan Heydari, Akbar Hedayatizadeh-Omran, Mahmoo Moosazadeh   +4 more
doaj  

Palmitic Acid Promotes Antiviral Innate Immunity via ZDHHC20‐Mediated CMPK2 Palmitoylation

Advanced Science, EarlyView.
Metabolites have important functions in innate immune activation and regulation. Wang et al. uncover metabolic regulation of antiviral immunity through CMPK2 palmitoylation, which regulates CMPK2 mitochondrial localization and is promoted by ZDHHC20 but reversed by PPT1, inhibition of which antagonizes viral infection in mice.
Yujia Wang, Zenghui Cui, Yunkai Zhang, Zhiqing Li, Xuetao Cao   +4 more
wiley   +1 more source

Control of Branchionus sp. and Amoeba sp. in cultures of Arthrospira sp. Control de Branchionus sp. y Amoeba sp. en cultivos de Arthrospira sp.

Latin American Journal of Aquatic Research, 2012
Cultivation of cyanobacterium Arthrospira sp. has been developed in many countries for the production of proteins, pigments and other compounds. Outdoor mass cultures are often affected by biological contamination, drastically reducing productivity as ...
Carlos Méndez, Eduardo Uribe
doaj  

An Upgraded FOS/TAC Titration Model Integrating Phosphate Effects for Accurate Assessments of Volatile Fatty Acids and Alkalinity in Anaerobic Media

ChemEngineering
The accurate determination of volatile fatty acids (VFAs) and total alkalinity (TAC, mostly carried by bicarbonate ions) is critical for operating anaerobic digesters.
Xiaojun Liu, André Pauss, Laura André, Thierry Ribeiro   +3 more
doaj   +1 more source