Results 41 to 50 of about 22,328 (268)

QRICH1 Disrupts Endoplasmic Reticulum Homeostasis and Amplifies NF‐κB Signaling in Periodontal Ligament Stem Cells to Exacerbate Diabetic Periodontitis

open access: yesAdvanced Science, EarlyView.
QRICH1 has been established as a key factor contributing to impaired osteogenic potential and accelerated apoptosis of PDLSCs in diabetic periodontitis. QRICH1 not only significantly enhances UPR‐associated apoptotic signaling but also amplifies NF‐κB‐mediated inflammatory responses. Its inhibition restores osteogenic capacity and reduces alveolar bone
Han Li   +9 more
wiley   +1 more source

Reparación valvular aórtica bicúspide. Resultados

open access: yesCirugía Cardiovascular, 2020
Resumen: Introducción y objetivos: Las guías de práctica clínica no mencionan, específicamente, la reparación valvular en pacientes con insuficiencia aórtica y válvula aórtica bicúspide como alternativa al implante protésico. La reparación en bicúspides
Rubén Álvarez-Cabo   +14 more
doaj   +1 more source

Aortic annulus sizing in bicuspid and tricuspid aortic valves using CT in patients with surgical aortic valve replacement

open access: yesScientific Reports, 2021
The purpose of this study was to evaluate whether bicuspid anatomy affects the discrepancy between CT-derived annular size and intraoperative size. We retrospectively analyzed annular measurements in 667 patients who underwent surgical aortic valve ...
Jooae Choe   +5 more
doaj   +1 more source

KLF5 Downregulation Links Impaired BNIP3‐Mediated Mitophagy to Inflammatory Valve Remodeling in Calcific Aortic Valve Disease

open access: yesAdvanced Science, EarlyView.
In human CAVD, KLF5 is reduced in VIC‐rich regions and remodeling/stress‐associated VIC states. In VICs, KLF5 sustains BNIP3 promoter activity and BNIP3‐mediated mitophagy, thereby limiting cytosolic mtDNA accumulation. KLF5 loss weakens mitochondrial quality control and enhances mtDNA‐sensitive STING/NF‐κB/NLRP3 inflammatory signaling under osteogenic
Jin‐Hui Bian   +13 more
wiley   +1 more source

Comparable Outcomes of Bicuspid Aortic Valves for Rapid- Deployment Aortic Valve Replacement

open access: yesJournal of Chest Surgery, 2023
Background: Edwards Intuity is recognized as a relatively contraindicated bioprosthesis for bicuspid aortic valve disease. This study compared the early echocardiographic and clinical outcomes of rapid-deployment aortic valve replacement for bicuspid ...
Somin Im   +5 more
doaj   +1 more source

The first clinical data of the SAPIEN 3 aortic valve in the treatment of aortic stenosis in China

open access: yesFrontiers in Cardiovascular Medicine, 2023
BackgroundData on outcomes following transcatheter aortic valve replacement with SAPIEN 3 in China is limited as it was approved by the National Medical Products since 2020.
Xiaoke Shang   +16 more
doaj   +1 more source

Bicuspid aortic valve disease [PDF]

open access: yesCanadian Medical Association Journal, 2013
Bicuspid aortic valves are present in 1%–2% of the population, with men being 3 times more commonly affected than women. This disease is more than just anatomic variation and may be associated with other heart and aorta abnormalities as a result of molecular and connective tissue derangements.[1][
Katie L, Losenno, Michael W A, Chu
openaire   +2 more sources

Heterozygous Variants in LRP1 Cause a Neurodevelopmental Disorder With Congenital Heart Defects

open access: yesAmerican Journal of Medical Genetics Part A, EarlyView.
ABSTRACT LRP1 encodes the low‐density lipoprotein (LDL) receptor‐related protein 1 (LRP1), a transmembrane protein involved in endocytosis and activation of multiple signaling pathways. LRP1 variants have been implicated in the pathogenesis of congenital heart defects (CHD), Alzheimer's disease, and neurodevelopmental disorders (NDD).
Alyssa L. Rippert   +31 more
wiley   +1 more source

The surgical exposure of teeth - simplest, safest and best?

open access: yesAustralasian Orthodontic Journal, 1987
The alignment of impacted teeth forms an important part of the work load in orthodontic practice and involves co-operation between the oral surgeon and the orthodontist. Any tooth in either arch may be impacted.
Jacobs Stanley G.
doaj   +1 more source

Anterograde crossing of a bicuspid aortic valve through transseptal access to facilitate transcatheter aortic valve implantation

open access: yesHeart Views, 2021
Transcatheter aortic valve implantation (TAVI) for bicuspid aortic valve stenosis can pose several technical challenges including difficult valve crossing.
Bilal Bawamia   +3 more
doaj   +1 more source

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