Results 151 to 160 of about 92,101 (311)
Discovery of CRBN‐based molecular glue degraders targeting WIZ transcription factor
Bulletin of the Korean Chemical Society, EarlyView.This work reports the discovery of 9l, a novel cereblon‐based molecular glue degrader which targets the WIZ transcription factor. Compound 9l facilitates WIZ‐CRBN ternary complex formation to degrade WIZ, subsequently inducing γ‐globin expression in HUDEP‐2 cells and highlighting its potential as a sickle cell disease therapy.
Tae‐Jun Kim +8 more
wiley +1 more source
Demo 07-06 Rotating Stool and Bicycle Wheel
, 2001 A spinning bicycle wheel is held by the demonstrator, who in turn sits on a rotating stool that is isolated by low-friction bearings, as shown in Figure 1.
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Bulletin of the Korean Chemical Society, EarlyView.Targeting HPK1 is a promising strategy to restore T‐cell anti‐tumor immunity. We report the design and synthesis of novel 2,4‐diaminopyrimidine derivatives, focusing on systematic structure–activity relationship (SAR) analysis These findings identify key structural features for potent HPK1 inhibition, facilitating the discovery of next‐generation ...
Heechan Shin +3 more
wiley +1 more source
Improving bicycle helmet research: examining intervention studies and parental experiences [PDF]
, 2013 Despite the recognized protection provided by bicycle helmets, estimates indicate that only 25% of people wear one every time they ride. Although much research has focused on identifying determinants of bicycle helmet use, there has been limited success ...
Cathorall, Michelle L. +1 more
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Microtopography enhances intestinal drug absorption via Piezo1‐mediated tight junction modulation
BMEMat, EarlyView.Microtopography‐driven enhancement of oral peptide drug delivery by activating Piezo1 channels significantly improves paracellular permeability and bioavailability, offering a novel approach for optimizing macromolecule absorption in pharmaceutical formulations.
Yu Hu +12 more
wiley +1 more source
Underground Railroad Bicycle Route planned
, 2004 Adventure Cycling Association and The University of Pittsburgh's Center for Minority Health (CMH) have agreed to create an Underground Railroad Bicycle ...
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Revista Cubana de Estomatología, 2005 Se realizó un estudio descriptivo y transversal sobre aspectos diagnóstico-terapéuticos del trauma maxilofacial por accidente ciclístico en 194 pacientes con lesiones bucofaciales, atendidos en el Servicio de Cirugía Maxilofacial de Urgencia del Hospital
José Manuel Díaz Fernández +3 more
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Delay at bicycle passages and bicycle crossings
, 2022 In September 2014, a new regulation was proposed in Sweden, which indicates aset of rules of giving way under different types of bicycle intersections. Meanwhile,new definitions were endued to bicycle passages and bicycle crossings. After thepriority of cyclists is guaranteed at bicycle crossings, potential delay for motorvehicles in the mainstream ...
openaire +1 more source
Diet of bird‐like troodontid dinosaurs: synthesis of a contentious clade
Biological Reviews, EarlyView.ABSTRACT Troodontidae is a clade of small‐to medium‐sized maniraptoran theropods that mainly lived in Laurasia (modern Asia, North America and Europe) during the Jurassic and Cretaceous periods and are believed to have had a variety of diets. The uniqueness of troodontid teeth suggests that they diverged from the typical flesh‐based diet of non‐avian ...
Yui Chi Fan +2 more
wiley +1 more source
Active transportation measurement and benchmarking development : New Orleans pedestrian and bicycle count report, 2010-2011. [PDF]
Over the last decade, there has been a surge in bicycle and pedestrian use in communities that have invested in active transportation infrastructure and programming.
University of New Orleans. Transportation Institute +1 more
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