Bicyclic Peptide Antagonists Derived from Genetically Encoded Combinatorial Libraries
CHIMIA, 2011 Ligands based on bicyclic peptides can combine favourable properties of antibodies (good binding affinity and target specificity) and small molecule ligands (stability, access to chemical synthesis, diffusion properties) and might be suitable ...
Christian Heinis
doaj +1 more source
Flexible access to conformationally-locked bicyclic morpholines [PDF]
, 2013 A preparatively accessible route to a series of conformationally-locked bicyclic morpholines has been developed. This flexible approach allows for diversification in order for a small array of lead-like scaffolds to be synthesised from readily available ...
Brawn +20 more
core +1 more source
Acta Crystallographica Section E: Crystallographic Communications, 2022 The bicyclic imidazo[1,2-a]pyridine core in the molecule of the title compound, C10H7F3N2O, is planar within 0.004 (1) Å. In the crystal, the molecules are linked by pairs of C—H...N and C—H...O hydrogen bonds, forming strips.
Firudin I. Guseinov +5 more
doaj +1 more source
Target identification strategies in plant chemical biology [PDF]
, 2014 The current needs to understand gene function in plant biology increasingly require more dynamic and conditional approaches opposed to classic genetic strategies.
Dejonghe, Wim, Russinova, Eugenia
core +2 more sources
Ethyl 3-amino-2-cyano-4-(4-methoxyphenyl)-6- methylthieno[2,3-b]pyridine-5-carboxylate
IUCrData, 2017 In the title molecule, C19H17N3O3S, the bicyclic core is planar [maximum deviation = 0.0205 (1) Å] In the crystal, the molecules stack along the a-axis direction through π–π-stacking interactions between the bicyclic units with a small alternation in the
Etify A. Bakhite +4 more
doaj +1 more source
Stereodivergent, Diels-Alder-initiated organocascades employing α,β-unsaturated acylammonium salts: scope, mechanism, and application. [PDF]
, 2017 Chiral α,β-unsaturated acylammonium salts are novel dienophiles enabling enantioselective Diels-Alder-lactonization (DAL) organocascades leading to cis- and trans-fused, bicyclic γ- and δ-lactones from readily prepared dienes, commodity acid chlorides ...
Abbasov, Mikail E +3 more
core +2 more sources
The fluorine-NHC gauche effect: a structural and computational study [PDF]
, 2013 Herein, we report the synthesis and X-ray structural analysis of a collection of fluorinated metal N-heterocyclic carbenes (Ag, Au, Pd, Rh, Ir) and their precursor salts.
Gilmour, R. +4 more
core +1 more source
6-Methylsulfanyl-4H-pyrimido[1,6-a]pyrimidin-4-one
Acta Crystallographica Section E, 2009 Reaction of 2-(methylsulfanyl)pyrimidin-4-amine with the 5-(methoxyvinylidene) derivative of Meldrum's acid and subsequent heating of the product in Dowtherm fluid yielded the title compound, C8H7N3OS, which was proven to contain a bicyclic 4H-pyrimido[1,
Quinhua Huang +4 more
doaj +1 more source
Stereoisomerism in pentaerythritol-bridged cyclotriphosphazene tri-spiranes: spiro and ansa 1,3-propanediyldioxy disubstituted derivatives [PDF]
, 2005 Four isomeric products were isolated and purified from the reaction of 1,3-propanediol with the tetra-spirane cyclophosphazene-organophosphate compound (1): viz. the di-monospiro (2a), di-monoansa (2b) and two monospiro-monoansa derivatives (2c) and (2d).
Aylin, U. +6 more
core +1 more source
Diethyl 3-amino-6-methyl-4-[(E)-2-phenylethenyl]thieno[2,3-b]pyridine-2,5-dicarboxylate
IUCrData, 2016 In the title molecule, C22H22N2O4S, the bicyclic core is slightly folded [1.9 (1)°], while pairwise intermolecular N—H...O hydrogen bonding forms dimers across centers of symmetry.
Joel T. Mague +4 more
doaj +1 more source