Results 211 to 220 of about 51,375 (298)

The potential for biased signalling in the P2Y receptor family of GPCRs

British Journal of Pharmacology, EarlyView.
The purinergic receptor family is primarily activated by nucleotides, and contains members of both the G protein coupled‐receptor (GPCR) superfamily (P1 and P2Y) and ligand‐gated ion channels (P2X). The P2Y receptors are widely expressed in the human body, and given the ubiquitous nature of nucleotides, purinergic signalling is involved with a plethora
Claudia M. Sisk, Simon Pitchford, Graham Ladds   +2 more
wiley   +1 more source

Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt

British Journal of Pharmacology, EarlyView.
Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown, Alan Armstrong, David J. Mann   +2 more
wiley   +1 more source

Discovery of a Novel γ‐Glutamylcyclotransferase Inhibitor Plumbagin by Luminescence‐Based High‐Throughput Screening

Cancer Science, EarlyView.
A cell‐based high‐throughput screening system utilizing the luminescent probe LISA‐103 was developed to monitor γ‐glutamylcyclotransferase (GGCT) activity in cancer cells. Through this assay, plumbagin was identified as a novel GGCT inhibitor that induces cell cycle arrest and suppresses cancer cell growth. ABSTRACT γ‐Glutamylcyclotransferase (GGCT) is
Keiko Taniguchi, Yukie Nohara, Mano Horinaka, Kozue Nose, Masaya Mori, Hiromi Ii, Hiroko Kawakami, Kazuto Yano, Susumu Nakata, Taku Yoshiya, Toshiyuki Sakai   +10 more
wiley   +1 more source

Spatial Access of America: Multiple indicators of accessibility to opportunities. [PDF]

Sci Data
Verma R, Mittal S, Ukkusuri SV.
europepmc   +1 more source

Mixed Super‐Circles

Computer Graphics Forum, EarlyView.
Abstract We introduce mixed super‐circles, a position‐curvature formulation of the original dynamic 2D super‐helix model. Compared to the latter, purely curvature‐based model – the so‐called chained formulation –, the mixed formulation that we propose here drastically reduces the algorithmic complexity of the solving scheme – from quadratic to quasi ...
Emile Hohnadel, Thibaut Métivet, Florence Bertails‐Descoubes   +2 more
wiley   +1 more source

Opportunity and risk interventions: distinct mechanisms to reduce disease burden. [PDF]

Am J Epidemiol
Snowden JM, Marcus JL.
europepmc   +1 more source

Environmental supportiveness, physical activity, and sedentary time in children with cerebral palsy

Developmental Medicine &Child Neurology, EarlyView.
Greater environmental supportiveness in home, school, and community settings was associated with reduced sedentary time among children with cerebral palsy, while home environmental supportiveness was related to increased light‐intensity physical activity.
Stina Oftedal, Ellen Armstrong, Gaela Kilgour, Matthew Ahmadi, Stewart G. Trost, Sean A. Horan, Christopher Carty, Denise Brookes, Roslyn N. Boyd, Leanne Sakzewski, Sarah E. Reedman   +10 more
wiley   +1 more source

What's the worth of a promise? Evaluating the long‐term effects of a programme to reduce early marriage in India

Economica, EarlyView.
Abstract This paper examines the long‐term effects of ‘Apni Beti Apna Dhan’ (ABAD), a unique conditional cash transfer programme implemented in the north Indian state of Haryana from 1994 to 1998. The programme provided bonds to female beneficiaries at birth, redeemable on attaining 18 years of age, if they remained unmarried. In particular, we examine
Shreya Biswas, Upasak Das
wiley   +1 more source

A Systematic Review for Guidelines: Sports and High-Grade Kidney Injuries in Children With Solitary Kidneys. [PDF]

Acta Paediatr
Palmer J, Johnstone LM, Deshpande A, Boyer O, Blanc T, Taghavi K.   +5 more
europepmc   +1 more source

Chasing the perfida Albione: Anglo‐Italian productivity gap in the late 1930s

The Economic History Review, EarlyView.
Abstract This paper presents new estimates of Anglo‐Italian labour productivity levels in manufacturing in the late 1930s, derived using the standard single‐deflation approach. The findings confirm a substantial productivity gap between Italy and the United Kingdom at the aggregate level, alongside pronounced intersectoral heterogeneity.
Tancredi Salamone
wiley   +1 more source