Results 41 to 50 of about 464,601 (309)

Elucidating the causal relationship between gut microbiota, metabolites, and diabetic nephropathy in European patients: Revelations from genome-wide bidirectional mendelian randomization analysis

Frontiers in Endocrinology
ObjectivePrevious observational studies suggest a potential link between gut microbiota, metabolites, and diabetic nephropathy. However, the exact causal relationship among these factors remains unclear.MethodWe conducted a two-sample bidirectional ...
Siyuan Song, Li Ning, Jiangyi Yu
doaj   +1 more source

Systemic inflammatory regulators and proliferative diabetic retinopathy: A bidirectional Mendelian randomization study

Frontiers in Immunology, 2023
BackgroundIncreasing evidence shows that systemic inflammation is an embedded mechanism of proliferative diabetic retinopathy (PDR). However, the specific systemic inflammatory factors involved in this process remained obscure.
Qiqin Shi, Qiangsheng Wang, Zhenqian Wang, Jiawen Lu, Ruobing Wang   +4 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Adolescent Callous-Unemotional Traits Mediates the Longitudinal Association between Conduct Problems and Media Violence Exposure

Societies, 2013
The current study investigates the bidirectional longitudinal association between conduct problems (CPs) and media violence exposure (MVE), with callous-unemotional (CU) traits as a potential mediator of this association.
Kostas. A. Fanti, Maria-Zoe Hadjicharalambous, Evita Katsimicha   +2 more
doaj   +1 more source

Bidirectional Ventricular Tachycardia

Journal of the American College of Cardiology, 2009
![Figure][1] Bidirectional ventricular tachycardia is a hallmark of severe digitalis toxicity. The 12-lead electrocardiogram obtained from a 54-year-old man with acute heart failure and digitoxin intoxication shows typical features of this potentially life-threatening arrhythmia: a ...
Richter, S., Brugada, Pedro
openaire   +3 more sources

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Association of circulating inflammatory proteins with type 2 diabetes mellitus and its complications: a bidirectional Mendelian randomization study

Frontiers in Endocrinology
BackgroundIncreasing evidence indicates that immune response underlies the pathology of type 2 diabetes (T2D). Nevertheless, the specific inflammatory regulators involved in this pathogenesis remain unclear.MethodsWe systematically explored circulating ...
Ying-Chao Liang, Ming-Jie Jia, Ling Li, De-Liang Liu, Shu-Fang Chu, Hui-Lin Li   +5 more
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

The gut microbiota and post-traumatic major depression disorder: insights from bidirectional two-sample Mendelian randomization

Frontiers in Psychiatry
BackgroundExposure to trauma is often associated with an increased incidence of Major Depressive Disorder (MDD), yet the mechanisms underlying MDD development post-trauma remain elusive.
Shan Liu, Yu Wang, Yonghu Zhang, Liang Zeng, Lin Ling, Yong Luo, Wenjie Liu   +6 more
doaj   +1 more source

A Contention-Based Hop-By-Hop Bidirectional Congestion Control Algorithm for Ad-Hoc Networks

Sensors, 2019
Existing hop-by-hop congestion control algorithms are mainly divided into two categories: those improving the sending rate and those suppressing the receiving rate. However, these congestion control algorithms have problems with validity and limitations.
Jiashuai Wang, Xiaoping Yang, Ying Liu, Zhihong Qian   +3 more
doaj   +1 more source