Results 141 to 150 of about 6,021 (251)

Artificial Intelligence‐Driven Natural Product Drug Discovery: From Computational Genome Mining to Clinical Translation

Medicinal Research Reviews, EarlyView.
ABSTRACT Natural products (NPs) have historically yielded numerous therapeutic agents, yet their integration into modern drug discovery has been constrained by chemical complexity, low abundance, laborious dereplication, and limited target annotation.
Antonio Lavecchia
wiley   +1 more source

Design of a Novel Gripping Mechanism and Dual Manipulator Robotic System for Apple Harvesting Using Tractor

Journal of Field Robotics, EarlyView.
ABSTRACT The architecture of apple orchards can be converted to easier operation by implementing the use of a low‐cost, tractor‐mounted, dual manipulator based on a robotic harvesting system with lower degrees of freedom (DoF). To accurately avoid injuries by detecting apples, an efferent, real‐time vision system that includes a new gripping mechanism ...
R. M. Rasika D. Abeyrathna, Victor Massaki Nakaguchi, Zifu Liu, Tofael Ahamed   +3 more
wiley   +1 more source

Construction of a deep learning-based predictive model for delayed graft function in kidney transplantation. [PDF]

Curr Urol
He Y, Sun W, Deng Y, Ding Z, Ma C, Sun S, Zhao Y, Wang J.   +7 more
europepmc   +1 more source

Neurotrophic Signaling, Sleep Physiology, and Retinal Neuroprotection: Integrative Mechanisms and Therapeutic Implications for Glaucoma

Sensory Neuroscience, EarlyView.
Glaucoma is increasingly understood as a neurodegenerative disorder shaped by sleep and circadian physiology, not intraocular pressure alone. Sleep loss and obstructive sleep apnea suppress BDNF–TrkB neurotrophic signaling, impair sleep‐dependent glymphatic clearance, and trigger microglial neuroinflammation and vascular insult at the optic nerve head,
Karyme M. Alemán‐Villa, Emiliano Terán, Javier A. Magaña‐Gómez, Loranda Calderón‐Zamora, Beatriz K. De la Herrán‐Arita, Alberto K. De la Herrán‐Arita   +5 more
wiley   +1 more source

A Review of Deep Learning Methods for Irregularly Sampled Medical Time Series Data. [PDF]

Health Data Sci
Sun C, Song M, Cai D, Zhang B, Li H, Hong S.   +5 more
europepmc   +1 more source

Brain‐Inspired Neuromorphic Device for Artificial Intelligent Robots Applications

SmartBot, EarlyView.
Brain‐inspired neuromorphic devices mimic biological systems to provide an efficient hardware foundation for embodied intelligent robotics. This review explores the material systems and corresponding computing architectures of neuromorphic devices that support low‐power perception, adaptive learning, and real‐time decision‐making.
Jiachen Han, Zheng Wang, Tianyu Wang, Jialin Meng   +3 more
wiley   +1 more source

Fault Diagnosis Method for Reciprocating Compressors Based on Spatio-Temporal Feature Fusion. [PDF]

Sensors (Basel)
Xu H, Ji X, Qin X, An W, Zhang F, Duan L, Wang J.   +6 more
europepmc   +1 more source

A Compact Annular Electrostatic Clutch Joint: Dynamic Response Modeling and Time‐Sharing Control for Underactuated Robots

SmartBot, EarlyView.
ABSTRACT Electrostatic clutches offer immense potential for programmable variable stiffness in multi‐degree‐of‐freedom (DOF) robotic systems. However, their practical deployment in continuous motion is fundamentally bottlenecked by two challenges: spatial constraints in existing parallel‐plate configurations and the lack of electromechanical coupling ...
Haochen Yong, Jian Wang, Zhisheng Xia, Zhexuan Li, Han Ding, Zhigang Wu   +5 more
wiley   +1 more source

Detection of Polyphonic Alarm Sounds From Medical Devices Using Frequency-Enhanced Deep Learning: Simulation Study. [PDF]

JMIR Med Inform
Kishimoto K, Takemura T, Sugiyama O, Kojima R, Yakami M, Yamamoto G, Kuroda T.   +6 more
europepmc   +1 more source

Artificial intelligence empowers targeted protein degradation: Core technological innovations, multi‐scenario applications, and translational prospects

Smart Molecules, EarlyView.
AI is transforming TPD by improving the design, prediction, and optimization of degraders such as PROTACs, molecular glues, and LYTACs. This review summarizes key AI‐driven advances, highlights applications across drug discovery stages, and discusses remaining challenges and future directions for accelerating the development of therapies against ...
Shuanglin Qin, Rui Peng, Guangshuai Zhang, Si Yan, Jin Xiao, Zishu Liu, Ziyu Tan, Qingqing Xie, Shangjie Li, Wei Luo, Xiaohe Xiao   +10 more
wiley   +1 more source