Results 111 to 120 of about 25,203,054 (312)

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

A SIR Model with Incomplete Data for the Analysis of Influenza A Spread in Ningbo

Discrete Dynamics in Nature and Society
In this article, the SIR model is used to fit the spread of influenza A in Ningbo, ranging from January 1, 2023 to June 30, 2023. The data that can be collected is the daily newly confirmed cases, but the daily number of infected individuals and ...
Bingqing Wang, Yanyao Hu, Zhongdi Cen, Jian Huang, Tianfeng He, Aimin Xu   +5 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

CAPTURE-24: A large dataset of wrist-worn activity tracker data collected in the wild for human activity recognition

Scientific Data
Existing activity tracker datasets for human activity recognition are typically obtained by having participants perform predefined activities in an enclosed environment under supervision. This results in small datasets with a limited number of activities
Shing Chan, Yuan Hang, Catherine Tong, Aidan Acquah, Abram Schonfeldt, Jonathan Gershuny, Aiden Doherty   +6 more
doaj   +1 more source

Research on Factors Affecting Global Grain Legume Yield Based on Explainable Artificial Intelligence

Agriculture
Grain legumes play a significant global role and are integral to agriculture and food production worldwide. Therefore, comprehending and analyzing the factors that influence grain legume yield are of paramount importance for guiding agricultural ...
Yadong Li, Rujia Li, Rongbiao Ji, Yehui Wu, Jiaojiao Chen, Mengyao Wu, Jianping Yang   +6 more
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

CTI-Thinker: an LLM-driven system for CTI knowledge graph construction and attack reasoning

Cybersecurity
With the increasing frequency of APT attacks, cyber defense urgently demands high-quality threat intelligence support. Cyber threat intelligence (CTI) knowledge graphs have demonstrated significant potential in aiding threat detection and behavioral ...
Xiuzhang Yang, Ruijie Zhong, Yuling Chen, Guojun Peng, Di Yao, Chaofan Chen, Chenyang Wang, Dongni Zhang, Yilin Zhou, Zixuan Yang   +9 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source