Results 111 to 120 of about 25,420,692 (388)

C9orf72 ALS‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules

FEBS Letters, EarlyView.
Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican, Yara Nabawi, William Hongyu Zhang, Dunja Petrovic, Markus Wehrmann, Sara Muñoz‐García, Seda Koyuncu, David Vilchez   +7 more
wiley   +1 more source

Novel and unscrutinized immune entities of the zebrafish gut

FEBS Letters, EarlyView.
Understudied cells of the zebrafish immune system include bona fide immune cells and epithelial (‐derived) cells with immune functions. Research focusing on zebrafish cells which demonstrate similarities to mammalian immune cell counterparts may help us understand the pathologies in which they are implicated. Currently available and advanced tools make
Audrey Inge Schytz Andersen‐Civil, Marine Mantel, Julia Soh, Serge Mostowy, Sylvia Brugman, Gilles Claude Vanwalleghem   +5 more
wiley   +1 more source

Information Splitting for Big Data Analytics

, 2016
Many statistical models require an estimation of unknown (co)-variance parameter(s) in a model. The estimation usually obtained by maximizing a log-likelihood which involves log determinant terms. In principle, one requires the \emph{observed information}
Gu, Tongxiang, Mo, Zeyao, Xu, Xiaowen, Zhu, Shengxin   +3 more
core   +1 more source

From lactation to malignancy: A comparison between healthy and cancerous breast gland at single‐cell resolution reveals new issues for tumorigenesis

FEBS Letters, EarlyView.
Single‐cell RNA sequencing reveals an opposite role of SLPI in basal tumors based on metastatic spread, along with shared activation of specific regulons in cancer cells and mature luminal lactocytes, as well as downregulation of MALAT1 and NEAT1 in the latter.
Pietro Ancona, Carlo M. Bergamini, Carlo Ferrari, Stefano Volinia, Nicoletta Bianchi   +4 more
wiley   +1 more source

Impact of Biases in Big Data [PDF]

, 2018
The underlying paradigm of big data-driven machine learning reflects the desire of deriving better conclusions from simply analyzing more data, without the necessity of looking at theory and models. Is having simply more data always helpful? In 1936, The
Glauner, Patrick, State, Radu, Valtchev, Petko   +2 more
core   +1 more source

The Carbon Emission Reduction Effect and Spatio-Temporal Heterogeneity of the Science and Technology Finance Network: The Combined Perspective of Complex Network Analysis and Econometric Models

Systems
With the active promotion of the “carbon peaking and carbon neutrality” goals, science and technology finance (STF) is the important driving force of low-carbon development, and financial networks facilitate the aggregation and transformation of ...
Juan Liang, Rui Ding, Xinsong Ma, Lina Peng, Kexin Wang, Wenqian Xiao   +5 more
doaj   +1 more source

Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells

FEBS Letters, EarlyView.
Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura, Lixiang Wang, Nao Hasuzawa, Ayako Nagayama, Sawako Moriyama, Kenji Ashida, Yoshinori Moriyama, Masatoshi Nomura, Ken Yamamoto   +8 more
wiley   +1 more source

Alliance for a Data Revolution: CGIAR Platform for Big Data in Agriculture 2017 Convention Report

, 2017
On September 19-22, 2017 the Consultative Group for International Agricultural Research1 (CGIAR) gathered over 300 local and international researchers, non-profits, public and private sector actors for the first CGIAR Platform for Big Data in Agriculture
CGIAR Platform for Big Data in Agriculture
core  

Managing Research Data in Big Science [PDF]

, 2012
The project which led to this report was funded by JISC in 2010--2011 as part of its 'Managing Research Data' programme, to examine the way in which Big Science data is managed, and produce any recommendations which may be appropriate.
Carozzi, Tobia, Gray, Norman, Woan, Graham   +2 more
core   +1 more source

Big Data [PDF]

International Journal of Pharmacy Practice, 2018
African Institute for mathematical Science ...
openaire   +4 more sources