Results 151 to 160 of about 1,284,460 (362)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Multi-omics insight into the molecular networks of mental disorder related genetic pathways in the pathogenesis of inflammatory bowel disease

Translational Psychiatry
Mental disorders are associated with inflammatory bowel disease (IBD), but the genetic pathophysiology is not fully understood. We obtained data on mental disorder-related gene methylation, expression, protein levels, and summary statistics of IBD, and ...
Meng Zhang, Jianhui Zhao, Haosen Ji, Yuqian Tan, Siyun Zhou, Jing Sun, Yuan Ding, Xue Li   +7 more
doaj   +1 more source

A Multimodal Recommender System Using Deep Learning Techniques Combining Review Texts and Images

Applied Sciences
Online reviews that consist of texts and images are an essential source of information for alleviating data sparsity in recommender system studies.
Euiju Jeong, Xinzhe Li, Angela (Eunyoung) Kwon, Seonu Park, Qinglong Li, Jaekyeong Kim   +5 more
doaj   +1 more source

Big Data Analytics and Machine Learning for Smart Agriculture [PDF]

openalex   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Real-Time Big Data Analytics: Investigating Different Application Domains

, 2017
Eman A. Alhazmi, Walaa A. Bajunaid, Fahd S. Alotaibi   +2 more
openalex   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Machine learning for predicting all-cause mortality of metabolic dysfunction-associated fatty liver disease: a longitudinal study based on NHANES

BMC Gastroenterology
Background The mortality burden of metabolic dysfunction-associated fatty liver disease (MAFLD) is rising, making it crucial to predict mortality and identify the factors influencing it.
Xueni Wang, Huihui Chen, Luqiao Wang, Wenguang Sun   +3 more
doaj   +1 more source

Big data analytics application in multi-criteria decision making: the case of eWallet adoption

, 2022
Babak Naysary, Mehdi Malekzadeh, Ruth Tacneng, Amine Tarazi   +3 more
openalex   +1 more source

DXP: Billing Data Preparation for Big Data Analytics [PDF]

, 2023
Luca Gagliardelli, Domenico Beneventano, M. Esposito, Luca Zecchini, Giovanni Simonini, Sonia Bergamaschi, Fabio Miselli, Giuseppe Miano   +7 more
openalex   +1 more source