Results 131 to 140 of about 24,236,404 (304)

A Methodology for Cross-Platform, Event-Driven Big Data Analytics-as-a-Service

, 2019
The advent of Big Data has revolutionized the way in which data are collected, analyzed, and processed, becoming a pre-requisite for each enterprise that competes in the global market.
Bellandi V., Damiani E., Ceravolo P., Finazzo R., Ardagna C. A.   +4 more
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Big Data Analytics for Obesity Prediction

, 2018
Feature selection (FS) is essential for the analysis of genomic datasets with millions of features. In such context, Big Data tools are paramount, but the use of standard machine learning models is limited for data with such low instances to features ratios.
Bilal , Ahsan, Vellido Alcacena, Alfredo, Ribas Ripoll, Vicent   +2 more
openaire   +4 more sources

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Identification of potential susceptibility loci for non-small cell lung cancer through whole genome sequencing in circadian rhythm genes

Scientific Reports
Lung cancer is a malignant tumor with a high morbidity and mortality rate worldwide, causing an increasing disease burden. Of these, the most common type is non-small cell lung cancer (NSCLC), which accounts for 80–85% of all lung cancer cases.
Xiaohang Xu, Luopiao Xu, Zeyong Lang, Gege Sun, Junlong Pan, Xue Li, Zilong Bian, Xifeng Wu   +7 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Metabolic syndrome including both elevated blood pressure and elevated fasting plasma glucose is associated with higher mortality risk: a prospective study

Diabetology & Metabolic Syndrome
Background Metabolic syndrome (MetS) encompasses a collection of metabolic abnormalities. This study aims to determine which combination of MetS components has the highest mortality risk, and to investigate the causal relationships between MetS ...
Shu Li, Chi Pang Wen, Huakang Tu, Sicong Wang, Xue Li, Andi Xu, Wenyuan Li, Xifeng Wu   +7 more
doaj   +1 more source

Information Security Analytics Finding Security Insights, Patterns, and Anomalies in Big Data

, 2015
Information Security Analytics gives you insights into the practice of analytics and, more importantly, how you can utilize analytic techniques to identify trends and outliers that may not be possible to identify using traditional security analysis ...
Miyamoto, I., Talabis, Mark
core  

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source