Results 111 to 120 of about 24,236,404 (304)

Development and application of a deep learning-based comprehensive early diagnostic model for chronic obstructive pulmonary disease

open access: yesRespiratory Research
Background Chronic obstructive pulmonary disease (COPD) is a frequently diagnosed yet treatable condition, provided it is identified early and managed effectively.
Zecheng Zhu   +9 more
doaj   +1 more source

A Stable Multi-Object Tracking Method for Unstable and Irregular Maritime Environments

open access: yesJournal of Marine Science and Engineering
In this study, an improved stable multi-object simple online and real-time tracking (StableSORT) algorithm that was specifically designed for maritime environments was proposed to address challenges such as camera instability and irregular object motion.
Young-Suk Han, Jae-Yoon Jung
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

BigExcel : a web-based framework for exploring big data in Social Sciences [PDF]

open access: yes, 2014
This research was pursued through an Amazon Web Services Education Research Grant. The first author was the recipient of an Erasmus Mundus scholarship.This paper argues that there are three fundamental challenges that need to be overcome in order to ...
Saleem, Muhammed Asif   +5 more
core   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Correction: Lee, J.; Kang, Y. A Dynamic Algorithm for Measuring Pedestrian Congestion and Safety in Urban Alleyways. ISPRS Int. J. Geo-Inf. 2024, 13, 434

open access: yesISPRS International Journal of Geo-Information
We would like to address and correct errors found in the original publication of our article [...]
Jiyoon Lee, Youngok Kang
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

Intelligent Network Design Driven by Big Data Analytics, IoT, AI and Cloud Computing

open access: yes, 2022
As enterprise access networks evolve with a larger number of mobile users, a wide range of devices and new cloud-based applications, managing user performance on an end-to-end basis has become rather challenging.
Mapp G., Cengiz K., Kumar S.
core   +1 more source

Big data analytics and applications of sentiment analysis and advanced machine learning models in consumer studies

open access: yes, 2022
reservedIn this thesis the focus is on big data analytics, machine learning and sentiment analysis. In the first part there are some analysis performed on consumer tests with innovative machine learning methods.
MOLENA, ALBERTO
core  

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

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