Results 121 to 130 of about 54,363 (314)
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Big Data Analytics: principles, trends and tasks (a survey)
, 2019 We review directions (avenues) of Big Data analysis and their practical meaning as well as problems and tasks in this field. Big Data Analytics appears a dominant trend in development of modern information technologies for management and planning in ...
Balabanov, O.S.
core
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
A four-layer architecture for online and historical big data analytics
, 2016 Big data processing and analytics technologies have drawn much attention in recent years. However, the recent explosive growth of online data streams brings new challenges to the existing technologies.
Li, VOK +5 more
core +1 more source
FEBS Letters, EarlyView.The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson +6 more
wiley +1 more source
Big Data Analytics for Obesity Prediction
, 2018 Feature selection (FS) is essential for the analysis of genomic datasets with millions of features. In such context, Big Data tools are paramount, but the use of standard machine learning models is limited for data with such low instances to features ratios.
Bilal , Ahsan +2 more
openaire +3 more sources
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
ACM SIGCOMM Workshop on Big Data Analytics and Machine Learning for Data Communication Networks [PDF]
, 2017 The explosion in volume and heterogeneity of data communication network measurements opens the door to the massive applica- tion of machine learning and artificial intelligence technology in networking.
Casas P. +3 more
core
Big data analytics for the virtual network topology reconfiguration use case
, 2016 ABNO's OAM Handler is extended with big data analytics capabilities to anticipate traffic changes in volume and direction. Predicted traffic is used to trigger virtual network topology re-optimization.
Morales Alcaide, Fernando +3 more
core +1 more source