Results 51 to 60 of about 115,029 (313)
The peculiar characteristics and advancement in diagnostic methodologies of influenza A virus
Frontiers in MicrobiologyInfluenza A virus (IAV) is a significant public health concern, causing seasonal outbreaks and occasional pandemics. These outbreaks result from changes in the virus’s surface proteins which include hemagglutinin and neuraminidase.
Muhammad Asif Raza +10 more
doaj +1 more source
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
Big Data Coordination Platform: Full Proposal 2017-2022 [PDF]
, 2016 This proposal for a Big Data and ICT Platform therefore focuses on enhancing CGIAR and partner capacity to deliver big data management, analytics and ICT-focused solutions to CGIAR target geographies and communities.
CGIAR Platform for Big Data in Agriculture
core
α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates
FEBS Letters, EarlyView.Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino +2 more
wiley +1 more source
MicroorganismsInfluenza A virus (IAV) causes highly contagious respiratory disease worldwide, so prevention and control of IAV is extremely important. However, overuse of neuraminidase inhibitor (NAI) drugs leads to drug resistance.
Jing Wang +7 more
doaj +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Farm.ink Digital Learning Platform [PDF]
, 2022 In 2019 we completed work on the new web platform that translates the successful features of the prior farm.ink chatbot and group products to a more accessible, powerful and feature-rich platform for farmers.
CGIAR Platform for Big Data in Agriculture
core
Big Building Data - a Big Data Platform for Smart Buildings
Energy Procedia, 2017 Abstract Future buildings will more and more rely on advanced Building Management Systems (BMS) connected to a variety of sensors, actuators and dedicated networks. Their objectives are to observe the state of rooms and apply automated rules to preserve or increase comfort while economizing energy.
Lucy Linder +3 more
openaire +1 more source