Results 191 to 200 of about 20,567 (248)

Repression of LKB1 by miR-17∼92 Sensitizes MYC-Dependent Lymphoma to Biguanide Treatment

open access: yesCell Reports Medicine, 2020
Summary: Cancer cells display metabolic plasticity to survive stresses in the tumor microenvironment. Cellular adaptation to energetic stress is coordinated in part by signaling through the liver kinase B1 (LKB1)-AMP-activated protein kinase (AMPK ...
Said Izreig   +2 more
exaly   +3 more sources

Gaining Insight into Mitochondrial Targeting: AUTAC-Biguanide as an Anticancer Agent

open access: yesMolecules
AUTAC-Biguanide is a hybrid compound designed to target mitochondria, inducing their degradation by mitophagy. This study unveils the potential of biguanides as cancer cell-targeting agents, emphasizing AUTAC-Biguanide’s superior antiproliferative ...
Véronique Bourdeau   +2 more
exaly   +3 more sources

[Biguanide].

Nihon rinsho. Japanese journal of clinical medicine, 2015
Metformin, a biguanide, is considered in EASD and ADA to be a first-line glucose-lowering agent for patients with type 2 diabetes. The effectiveness of metformin as an anti-diabetic drug is explained by its ability to lower blood glucose by decreasing hepatic glucose production, stimulating glucose uptake in the muscle, and increasing fatty acid ...
Akio, Ohta, Yasushi, Tanaka
openaire   +1 more source

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