Predictors and Consequences of Delayed Insulin Initiation: A 20-year Retrospective Cohort Study on Diabetes Complications in Southern Thailand. [PDF]
Wang-Ae A +4 more
europepmc +1 more source
Antimicrobial functional ingredients used in hand hygiene products: a cross-sectional survey on regional e-commerce platforms in Wuhan area of China. [PDF]
Chen X, Wang J.
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The mediating effect role of methylmalonic acid on the association between oxidative balance score and diabetic kidney disease: a cross-sectional study from NHANES 2011-2014. [PDF]
Yang H +5 more
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Management of Severe Pediatric Lower Lip Defect After Canine Bite with Polyhexamethylene Biguanide (PHMB), Full-Thickness Skin Graft (FTSG) and Compression Foam: A Case Report. [PDF]
Lőrincz A +6 more
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Metformin in prostate cancer: a context-dependent antitumour strategy driven by metabolic vulnerability and signalling network. [PDF]
Yan L +7 more
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Repression of LKB1 by miR-17∼92 Sensitizes MYC-Dependent Lymphoma to Biguanide Treatment
Summary: Cancer cells display metabolic plasticity to survive stresses in the tumor microenvironment. Cellular adaptation to energetic stress is coordinated in part by signaling through the liver kinase B1 (LKB1)-AMP-activated protein kinase (AMPK ...
Said Izreig +2 more
exaly +3 more sources
Gaining Insight into Mitochondrial Targeting: AUTAC-Biguanide as an Anticancer Agent
AUTAC-Biguanide is a hybrid compound designed to target mitochondria, inducing their degradation by mitophagy. This study unveils the potential of biguanides as cancer cell-targeting agents, emphasizing AUTAC-Biguanide’s superior antiproliferative ...
Véronique Bourdeau +2 more
exaly +3 more sources
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Metformin, a biguanide, is considered in EASD and ADA to be a first-line glucose-lowering agent for patients with type 2 diabetes. The effectiveness of metformin as an anti-diabetic drug is explained by its ability to lower blood glucose by decreasing hepatic glucose production, stimulating glucose uptake in the muscle, and increasing fatty acid ...
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