Results 1 to 10 of about 14,382 (155)

Contact allergy to polyhexamethylene biguanide (polyaminopropyl biguanide) [PDF]

Contact Dermatitis, 2020
AbstractBackgroundPolyaminopropyl biguanide (INCI name) and polyhexamethylene biguanide (PHMB) are polymeric biguanides. PHMB is a broad‐spectrum antimicrobial substance used as a preservative in many products. Due to our limited knowledge on PHMB contact allergy frequency and the fact that cases of allergic contact dermatitis to PHMB might be missed ...
Thanisorn Sukakul, Jakob Dahlin, Ann Pontén, Annarita Antelmi, Magnus Bruze, Nils Hamnerius, Inese Hauksson, Marléne Isaksson, Tina Lejding, Cecilia Svedman   +9 more
openaire   +4 more sources

Repositioning of Verrucosidin, a purported inhibitor of chaperone protein GRP78, as an inhibitor of mitochondrial electron transport chain complex I. [PDF]

, 2013
Verrucosidin (VCD) belongs to a group of fungal metabolites that were identified in screening programs to detect molecules that preferentially kill cancer cells under glucose-deprived conditions.
Chen, Thomas C, Gonzalez, Reyna, Hofman, Florence M, Louie, Stan G, Pao, Peng-Wen, Pirrung, Michael C, Schönthal, Axel H, Sharma, Natasha, Thomas, Simmy   +8 more
core   +7 more sources

Metformin induces distinct bioenergetic and metabolic profiles in sensitive versus resistant high grade serous ovarian cancer and normal fallopian tube secretory epithelial cells. [PDF]

, 2017
Metformin is a widely used agent for the treatment of diabetes and infertility, however, it has been found to have anti-cancer effects in a variety of malignancies including high grade serous ovarian cancer (HGSC).
Aspuria, Paul-Joseph P, Hodeib, Melissa, Karlan, Beth Y, Lunt, Sophia Y, Ogrodzinski, Martin P, Reue, Karen, Vergnes, Laurent   +6 more
core   +1 more source

Molecular features of biguanides required for targeting of mitochondrial respiratory complex I and activation of AMP-kinase. [PDF]

, 2016
BACKGROUND: The biguanides are a family of drugs with diverse clinical applications. Metformin, a widely used anti-hyperglycemic biguanide, suppresses mitochondrial respiration by inhibiting respiratory complex I. Phenformin, a related anti-hyperglycemic
Agip, Ahmed-Noor A, Bridges, Hannah R, Hirst, Judy, Sirviö, Ville A   +3 more
core   +1 more source

Editorial:Metformin: Beyond Diabetes [PDF]

, 2019
International ...
Bost, Canto, El-Mir, Evans, Ferreira, Foretz, Foretz, Forslund, Hawley, Kaminski, Leung, Madiraju, Martin-Montalvo, Mohan, Neumann, Owen, Patel, Rena, Saxton, Zhou   +19 more
core   +4 more sources

The antimicrobial polymer PHMB enters cells and selectively condenses bacterial chromosomes [PDF]

, 2016
To combat infection and antimicrobial resistance, it is helpful to elucidate drug mechanism(s) of action. Here we examined how the widely used antimicrobial polyhexamethylene biguanide (PHMB) kills bacteria selectively over host cells.
A Gentile, B Spellberg, CE Barry, CR Messick, DJ Dwyer, EE Creppy, EF Palermo, FW O’Grady, G Muller, G Muller, G Rusciano, GS Gordon, J Portugal, JD McCool, JM Boberek, JP Armitage, L Good, LP O’Malley, M Mondhe, MA Kohanski, MJ Allen, MJ Allen, MJ Allen, N Nekhotiaeva, Nakashima, P Broxton, P Broxton, P Broxton, P Erbacher, P Gilbert, R de Vries, R Dryselius, R Firdessa, R Spurio, RF Murphy, S Amoils, S Goh, S Wessels, T Ikeda, T Ikeda, T Kornberg, VB Teif   +41 more
core   +3 more sources

Phenformin, but not metformin, delays development of T-cell acute lymphoblastic leukemia/lymphoma via cell-autonomous AMPK activation [PDF]

, 2019
Summary: AMPK acts downstream of the tumor suppressor LKB1, yet its role in cancer has been controversial. AMPK is activated by biguanides, such as metformin and phenformin, and metformin use in diabetics has been associated with reduced cancer risk ...
Atrih, Abdelmadjid, Cantrell, Doreen, Dandapani, Madhumita, Foretz, Marc, Grzes, Katarzyna, Hardie, D Grahame, Hardie, D. Grahame, Lamont, Douglas, Russell, Fiona, Vara-Ciruelos, Diana, Viollet, Benoit   +10 more
core   +4 more sources

Metformin use in pregnancy: promises and uncertainties [PDF]

, 2017
Metformin has been prescribed in pregnancy for over 40 years; for much of this time, use has been limited both in numbers and geographically, and the evidence base has been confined to observational studies.
Lindsay, Robert S., Loeken, Mary R.
core   +1 more source

The risk of transmission of a viral haemorrhagic fever infection in a United Kingdom laboratory [PDF]

, 2017
No abstract ...
Shorten, Robert J., Wilson-Davies, Eleri
core   +2 more sources

LKB1 and AMPK and the cancer-metabolism link - ten years after [PDF]

, 2013
The identification of a complex containing the tumor suppressor LKB1 as the critical upstream kinase required for the activation of AMP-activated protein kinase (AMPK) by metabolic stress was reported in an article in Journal of Biology in 2003.
A Decensi, A Hemminki, A Mora, A Street, A Woods, A Woods, A Woods, AF Baas, AK Al-Hakim, AS Marsin, AS Marsin, B Faubert, B Xiao, B Xiao, B Zheng, C Algire, C Canto, CM Sutherland, CW Lee, CW Song, D Carling, D Grahame Hardie, Dario R Alessi, DB Shackelford, DB Shackelford, DE Jenne, DG Hardie, DG Hardie, DG Hardie, DM Gwinn, DR Alessi, G Manning, G Zhou, GM Merrill, GV Thomas, H Ji, HA Hirsch, HM O'Neill, J Boudeau, J Liang, J Mankouri, JM Evans, JM Kyriakis, JM Lizcano, JS Oakhill, K Barnes, K Imamura, K Inoki, K Kato, K Sakamoto, KI Mitchelhill, L Liu, LA Yeh, M Foretz, M Jaleel, M Pollak, M Sanchez-Cespedes, MG Vander Heiden, MR Owen, N Nath, N Stahmann, O Warburg, P Tamas, RG Jones, RJ Shaw, RL Hurley, RR Russell, S Fogarty, S Hadad, S Horman, S Niraula, S Suissa, SA Hawley, SA Hawley, SA Hawley, SA Hawley, SA Hawley, SH Koo, SM Jeon, SN Wingo, SP Davies, SP Hong, TL Yuan, TS Ingebritsen, U Andersson, W Liu, WW Winder, WW Winder, WW Winder, X Huang, Y Yang   +90 more
core   +4 more sources