Results 21 to 30 of about 9,814 (230)

A Review on Recent Advancement on Age-Related Hearing Loss: The Applications of Nanotechnology, Drug Pharmacology, and Biotechnology

Pharmaceutics, 2021
Aging is considered a contributing factor to many diseases such as cardiovascular disease, Alzheimer’s disease, and hearing loss. Age-related hearing loss, also termed presbycusis, is one of the most common sensory impairments worldwide, affecting one in
Jacqueline Chester, Edan Johnston, Daniel Walker, Melissa Jones, Corina Mihaela Ionescu, Susbin Raj Wagle, Božica Kovacevic, Daniel Brown, Momir Mikov, Armin Mooranian, Hani Al-Salami   +10 more
doaj   +1 more source

Structural basis of mammalian respiratory complex I inhibition by medicinal biguanides. [PDF]

, 2023
The molecular mode of action of biguanides, including the drug metformin, which is widely used in the treatment of diabetes, is incompletely characterized.
Blaza, James N, Chung, Injae, Hirst, Judy, Pollak, Michael N, Bridges, Hannah R, Yin, Zhan   +5 more
core   +4 more sources

Mono- and Dinuclear Aluminium Complexes Derived from Biguanide and Carbothiamide Ligands

Inorganics, 2021
Dianionic N,N-chelating ligands play a crucial role in coordination chemistry, but reports on related complexes remain limited to certain types of ligands.
Maximilian Dehmel, Helmar Görls, Robert Kretschmer   +2 more
doaj   +1 more source

Does atorvastatin work more effectively than biguanides in reducing cardiovascular risk factors?

Journal of Pharmacy and Bioallied Sciences, 2011
Increased risk of coronary artery disease in diabetic persons is associated with increased level of lipoproteins. Usually, such risks are reverted with glycemic control by antidiabetic medicines in Type I diabetes millitus.
Afshan Siddiq, Rafeeq Alam Khan, Sadia Ghousia Baig   +2 more
doaj   +1 more source

Noninsulin pharmacological management of type 1 diabetes mellitus

Indian Journal of Endocrinology and Metabolism, 2011
The injectable nature and other shortcomings of insulin have stimulated interest in studying the noninsulin pharmacological therapies to manage type 1 diabetes mellitus (T1DM).
Vishvas Garg
doaj   +1 more source

Molecular features of biguanides required for targeting of mitochondrial respiratory complex I and activation of AMP-kinase. [PDF]

, 2016
BACKGROUND: The biguanides are a family of drugs with diverse clinical applications. Metformin, a widely used anti-hyperglycemic biguanide, suppresses mitochondrial respiration by inhibiting respiratory complex I. Phenformin, a related anti-hyperglycemic

core   +5 more sources

Natural Products to Counteract the Epidemic of Cardiovascular and Metabolic Disorders

Molecules, 2016
Natural products have always been exploited to promote health and served as a valuable source for the discovery of new drugs. In this review, the great potential of natural compounds and medicinal plants for the treatment or prevention of cardiovascular ...
Birgit Waltenberger, Andrei Mocan, Karel Šmejkal, Elke H. Heiss, Atanas G. Atanasov   +4 more
doaj   +1 more source

Genotypic and Phenotypic Factors Influencing Drug Response in Mexican Patients With Type 2 Diabetes Mellitus

Frontiers in Pharmacology, 2018
The treatment of Type 2 Diabetes Mellitus (T2DM) consists primarily of oral antidiabetic drugs (OADs) that stimulate insulin secretion, such as sulfonylureas (SUs) and reduce hepatic glucose production (e.g., biguanides), among others.
Hector E. Sanchez-Ibarra, Luisa M. Reyes-Cortes, Xian-Li Jiang, Claudia M. Luna-Aguirre, Dionicio Aguirre-Trevino, Ivan A. Morales-Alvarado, Rafael B. Leon-Cachon, Fernando Lavalle-Gonzalez, Faruck Morcos, Faruck Morcos, Hugo A. Barrera-Saldaña, Hugo A. Barrera-Saldaña   +11 more
doaj   +1 more source

Ether lipid biosynthesis promotes lifespan extension and enables diverse pro-longevity paradigms in Caenorhabditis elegans

eLife, 2023
Biguanides, including the world’s most prescribed drug for type 2 diabetes, metformin, not only lower blood sugar, but also promote longevity in preclinical models.
Lucydalila Cedillo, Fasih M Ahsan, Sainan Li, Nicole L Stuhr, Yifei Zhou, Yuyao Zhang, Adebanjo Adedoja, Luke M Murphy, Armen Yerevanian, Sinclair Emans, Khoi Dao, Zhaozhi Li, Nicholas D Peterson, Jeramie Watrous, Mohit Jain, Sudeshna Das, Read Pukkila-Worley, Sean P Curran, Alexander A Soukas   +18 more
doaj   +1 more source

Biguanides, anion receptors and sensors

, 2017
Biguanides are strong bases (pKa > 10), their protonated forms bind anions and may therefore act as receptors for anions.
Mariia Pushina, Pavel Anzenbacher
core   +1 more source