Results 1 to 10 of about 856 (149)

Mechanisms of NMDA Receptor Inhibition by Biguanide Compounds

Pharmaceuticals
N-methyl-D-aspartate (NMDA) receptors are inhibited by many medicinal drugs. The recent successful repurposing of NMDA receptor antagonists ketamine and dextromethorphan for the treatment of major depressive disorder further enhanced the interest in this
Arseniy S. Zhigulin, Anastasiya O. Novikova, Oleg I. Barygin   +2 more
doaj   +1 more source

Pharmacological AMP kinase activators target the nucleolar organization and control cell proliferation.

PLoS ONE, 2014
AimsPhenformin, resveratrol and AICAR stimulate the energy sensor 5'-AMP activated kinase (AMPK) and inhibit the first step of ribosome biogenesis, de novo RNA synthesis in nucleoli.
Mohamed Kodiha, Ali Salimi, Yi Meng Wang, Ursula Stochaj   +3 more
doaj   +1 more source

Novel combination therapy with phenformin enhances the effects of lenvatinib in hepatocellular carcinoma via AMPK-mediated PDGFRβ degradation

Cancer Cell International
Background Hepatocellular carcinoma (HCC) is an invasive malignant tumour for which few effective treatment options are currently available. Lenvatinib is a small-molecule inhibitor of multiple receptor tyrosine kinases used for the treatment of patients
Duo Li, Qi Zhong, Di Xiao, Weifan Wang, Lejing Xie, Mei Peng, Cangcang Xu, Huaying Wu, Zhuan Li, Xiaoping Yang   +9 more
doaj   +1 more source

Complexes between the LKB1 tumor suppressor, STRADα/β and MO25α/β are upstream kinases in the AMP-activated protein kinase cascade

Journal of Biology, 2003
Background The AMP-activated protein kinase (AMPK) cascade is a sensor of cellular energy charge that acts as a 'metabolic master switch' and inhibits cell proliferation. Activation requires phosphorylation of Thr172 of AMPK within the activation loop by
Alessi Dario R, Mäkelä Tomi P, Mustard Kirsty J, Udd Lina, Reid Jennifer L, Boudeau Jérôme, Hawley Simon A, Hardie D Grahame   +7 more
doaj   +1 more source

Inhibition of Chloride Intracellular Channel 1 (CLIC1) as Biguanide Class-Effect to Impair Human Glioblastoma Stem Cell Viability

Frontiers in Pharmacology, 2018
The antidiabetic biguanide metformin exerts antiproliferative effects in different solid tumors. However, during preclinical studies, metformin concentrations required to induce cell growth arrest were invariably within the mM range, thus difficult to ...
Federica Barbieri, Roberto Würth, Alessandra Pattarozzi, Ivan Verduci, Chiara Mazzola, Maria G. Cattaneo, Michele Tonelli, Agnese Solari, Adriana Bajetto, Antonio Daga, Lucia M. Vicentini, Michele Mazzanti, Tullio Florio, Tullio Florio   +13 more
doaj   +1 more source

Targeting Tumor Mitochondrial Metabolism Overcomes Resistance to Antiangiogenics

Cell Reports, 2016
Epithelial malignancies are effectively treated by antiangiogenics; however, acquired resistance is a major problem in cancer therapeutics. Epithelial tumors commonly have mutations in the MAPK/Pi3K-AKT pathways, which leads to high-rate aerobic ...
Paloma Navarro, Maria J. Bueno, Ivana Zagorac, Tamara Mondejar, Jesus Sanchez, Silvana Mourón, Javier Muñoz, Gonzalo Gómez-López, Veronica Jimenez-Renard, Francisca Mulero, Navdeep S. Chandel, Miguel Quintela-Fandino   +11 more
doaj   +1 more source

The antitumor properties of metformin and phenformin reflect their ability to inhibit the actions of differentiated embryo chondrocyte 1

Cancer Management and Research, 2019
Chun-Lin Kuo,1 Shu-Man Hsieh Li,*,2 Shu-Yi Liang,*,2 Shu-Ting Liu,2 Li-Chun Huang,2 Wei-Ming Wang,3 Li-Chen Yen,2,4 Shih-Ming Huang21Department of Orthopaedic Surgery, Tri-Service General Hospital, National Defense Medical Center, Taiwan ...
Kuo CL, Hsieh Li SM, Liang SY, Liu ST, Huang LC, Wang WM, Yen LC, Huang SM   +7 more
doaj  

Metabolic modeling elucidates phenformin and atpenin A5 as broad-spectrum antiviral drugs against RNA viruses

Communications Biology
The SARS-CoV-2 pandemic has reemphasized the urgent need for broad-spectrum antiviral therapies. We developed a computational workflow using scRNA-Seq data to assess cellular metabolism during viral infection. With this workflow we predicted the capacity
Alina Renz, Mirjam Hohner, Raphaël Jami, Maximilian Breitenbach, Jonathan Josephs-Spaulding, Johanna Dürrwald, Lena Best, Victoria Dulière, Chloé Mialon, Stefanie M. Bader, Georgios Marinos, Nantia Leonidou, Filipe Cabreiro, Marc Pellegrini, Marcel Doerflinger, Manuel Rosa-Calatrava, Andrés Pizzorno, Andreas Dräger, Michael Schindler, Christoph Kaleta   +19 more
doaj   +1 more source

Optimization of biguanide derivatives as selective antitumor agents blocking adaptive stress responses in the tumor microenvironment

Drug Design, Development and Therapy, 2014
Kosuke Narise, Kensuke Okuda, Yukihiro Enomoto, Tasuku Hirayama, Hideko Nagasawa Laboratory of Pharmaceutical and Medicinal Chemistry, Gifu Pharmaceutical University, Daigaku-nishi, Gifu, Japan Abstract: Adaptive cellular responses resulting from ...
Narise K, Okuda K, Enomoto Y, Hirayama T, Nagasawa H   +4 more
doaj  

GFI1 enhances MHC-I expression in tumor cells and augments tumor responsiveness to PD-1/PD-L1 inhibitors

Cancer Immunology, Immunotherapy
Background Growth factor-independent-1 transcription repressor (GFI1) is crucial for determining the differentiation and fate of exhausted CD8+ T cells and affects immunotherapy outcomes.
Yu Xi, Kewei Xiao, Kelin Meng, Taiyan Yu, Tianlai Wang, Xu Wang, Ounan Pan, Chenxi Zeng, Xue Wang, Xiangning Fu, Lequn Li   +10 more
doaj   +1 more source