Results 41 to 50 of about 856 (149)

Some metabolic effects of phenformin and sodium dichloroacetate in rats. [PDF]

, 2018
An animal model of hyperlactataemia induced by phenformin, an orally-active antidiabetic drug, has been developed using streptozotocin-diabetic rats. A comparison of blood metabolite concentrations of fed, starved and streptozotocin-diabetic rats showed ...
Evans, Peter Francis.
core   +1 more source

Phenformin as prophylaxis and therapy in breast cancer xenografts

, 2012
BACKGROUND: Observations that diabetics treated with biguanide drugs have a reduced risk of developing cancer have prompted an enthusiasm for these agents as anti-cancer therapies.
Wullschleger, S., Kernohan, N. M., M V C L Appleyard, Fleming, S., K E Murray, Bray, S. E., Appleyard, M. V. C. L., P J Coates, Thompson, A. M., S Fleming, N M Kernohan, Coates, P. J., Murray, K. E., Alessi, D. R.; id_orcid, A M Thompson, S E Bray, S Wullschleger, D R Alessi   +17 more
core   +1 more source

Phenformin enhances the therapeutic benefit of BRAFV600E inhibition in melanoma

, 2019
Biguanides, such as the diabetes therapeutics metformin and phenformin, have demonstrated antitumor activity both in vitro and in vivo. The energy-sensing AMP-activated protein kinase (AMPK) is known to be a major cellular target of biguanides.
Perez-Lorenzo, Rolando, Lee, Jung Hyun, Zheng, Bin, Yuan, Ping, Guzzo, Christina Del, Ito, Koichi, Bosenberg, Marcus W., Cantley, Lewis C., Shen, Che-Hung, McMahon, Martin   +9 more
core   +1 more source

STAT1 potentiates oxidative stress revealing a targetable vulnerability that increases phenformin efficacy in breast cancer

Nature Communications, 2021
Complex I inhibition induces oxidative stress leading to cancer cell cytotoxicity. Here, the authors show, in breast cancer models, that inflammatory mediators can potentiate complex I inhibitor phenformin cytotoxicity through STAT1-mediated ...
Stephanie P. Totten, Young Kyuen Im, Eduardo Cepeda Cañedo, Ouafa Najyb, Alice Nguyen, Steven Hébert, Ryuhjin Ahn, Kyle Lewis, Benjamin Lebeau, Rachel La Selva, Valérie Sabourin, Constanza Martínez, Paul Savage, Hellen Kuasne, Daina Avizonis, Nancy Santos Martínez, Catherine Chabot, Adriana Aguilar-Mahecha, Marie-Line Goulet, Matthew Dankner, Michael Witcher, Kevin Petrecca, Mark Basik, Michael Pollak, Ivan Topisirovic, Rongtuan Lin, Peter M. Siegel, Claudia L. Kleinman, Morag Park, Julie St-Pierre, Josie Ursini-Siegel   +30 more
doaj   +1 more source

Hepatotoxic effects of ethanol and phenformin association in rats

, 1993
1. 1. The association of ethanol and phenformin during 6 months in the Sprague-Dawley rat produces an alteration in lactate homeostasis. A basal blood lactate value of 54.13 ± 15.43 mg/dl was found compared to 23.65 ± 7.4 mg/dl in control rats. 2.
Javier Flores-Alvarado, L., Ayub-Ayala, M., Feria-Velasco, A., Gasca-Centeno, E., Bueno-Topete, M.R., Ortiz, G.G.   +5 more
core   +1 more source

Unveiling Candidate Markers for Drug Resistance or Synthetic Lethality in Cervical Cancer: Integrative Analysis of Genetic and Pharmacoprofiling

Cancer Reports, Volume 9, Issue 6, June 2026.
ABSTRACT Introduction Systemic cervical cancer management continues to be challenging. Numerous chemotherapies have been approved, but predicting response is difficult due to the lack of biomarkers. Here, we analyze the genetic and protein profiles of 20 cervical cancer cell lines (CCCLs) and explore their correlation with drug response patterns to ...
Suzy Scholl, Elaine Del Nery, Pierre Gestraud, Maral Halladjian, Elodie Girard, Adèle Soria, Elodie Anthony, Leanne De Koning, Nicolas Servant, Els Berns, Maud Kamal   +10 more
wiley   +1 more source

Beyond Glycolysis: Targeting Non‐Glycolytic Metabolic Pathways in Brain Tumors for Therapeutic Innovation: A Narrative Review

Health Science Reports, Volume 9, Issue 6, June 2026.
ABSTRACT Background and Aims Metabolic reprogramming is a hallmark of brain tumors, extending beyond the classical Warburg effect. While glycolysis has been extensively studied, gliomas and pediatric high‐grade brain cancers demonstrate remarkable metabolic plasticity.
Iffat Islam Mayesha, Zubaier Ahmed, Ammarah Laaika Mohiuddin, Faiza Fairuz Muskan, Saiful Islam, Sharmin Jahan Sumaya   +5 more
wiley   +1 more source

Phenformin activates ER stress to promote autophagic cell death via NIBAN1 and DDIT4 in oral squamous cell carcinoma independent of AMPK

International Journal of Oral Science
The efficient clinical treatment of oral squamous cell carcinoma (OSCC) is still a challenge that demands the development of effective new drugs. Phenformin has been shown to produce more potent anti-tumor activities than metformin on different tumors ...
Dexuan Zhuang, Shuangshuang Wang, Huiting Deng, Yuxin Shi, Chang Liu, Xue Leng, Qun Zhang, Fuxiang Bai, Bin Zheng, Jing Guo, Xunwei Wu   +10 more
doaj   +1 more source

Mitochondrial reprogramming in lung cancer: a therapeutic vulnerability and a strategy for reversing drug resistance

The Journal of Pathology, Volume 269, Issue 2, Page 149-163, June 2026.
Abstract The conceptualization of mitochondria, previously restricted to their function as cellular ‘powerhouses’, has evolved to recognize their function as central coordinating hubs for the orchestration of cancer cell metabolism, signaling, and fate determination.
Woo Hyun Park
wiley   +1 more source

Nanog maintains stemness of Lkb1‐deficient lung adenocarcinoma and prevents gastric differentiation

EMBO Molecular Medicine, 2021
Growing evidence supports that LKB1‐deficient KRAS‐driven lung tumors represent a unique therapeutic challenge, displaying strong cancer plasticity that promotes lineage conversion and drug resistance.
Xinyuan Tong, Yueqing Chen, Xinsheng Zhu, Yi Ye, Yun Xue, Rui Wang, Yijun Gao, Wenjing Zhang, Weiqiang Gao, Lei Xiao, Haiquan Chen, Peng Zhang, Hongbin Ji   +12 more
doaj   +1 more source