Results 41 to 50 of about 3,344 (169)

Nanog maintains stemness of Lkb1‐deficient lung adenocarcinoma and prevents gastric differentiation

EMBO Molecular Medicine, 2021
Growing evidence supports that LKB1‐deficient KRAS‐driven lung tumors represent a unique therapeutic challenge, displaying strong cancer plasticity that promotes lineage conversion and drug resistance.
Xinyuan Tong, Yueqing Chen, Xinsheng Zhu, Yi Ye, Yun Xue, Rui Wang, Yijun Gao, Wenjing Zhang, Weiqiang Gao, Lei Xiao, Haiquan Chen, Peng Zhang, Hongbin Ji   +12 more
doaj   +1 more source

Protocols for analyzing metabolic derangements caused by increased NADH/NAD+ ratio in cell lines and in mice

STAR Protocols, 2022
Summary: Mitochondrial electron transport chain (ETC) dysfunction elevates the NADH/NAD+ ratio to cause metabolic derangements. Here we describe a protocol to measure the NADH/NAD+ ratio and analyze the rewiring of glucose metabolism using [4-2H]-glucose,
Shanshan Liu, Yan Ma, Hui Jiang
doaj   +1 more source

Defect engineering for highly efficient and stable perovskite top cells for Si tandems

Bulletin of the Korean Chemical Society, Volume 47, Issue 5, Page 527-550, May 2026.
Defect passivation in wide‐bandgap perovskites is essential for enabling high‐efficiency and stable perovskite/Si tandem solar cells. Bulk, surface, and buried‐interface passivation strategies focus on suppressing nonradiative recombination, ion migration, and halide segregation, thereby clarifying critical design principles for next‐generation tandem ...
Ju Yeong Hong, Young Seon Yoon, Jin Young Kim   +2 more
wiley   +1 more source

NDUFS1‐Mediated Mitochondrial Complex I Activity Maintains Pancreatic Cancer Stemness by Promoting PAX2 Hypomethylation

MedComm, Volume 7, Issue 4, April 2026.
Pancreatic cancer stem cells (CSCs) maintain stemness and tumorigenicity through NDUFS1‐mediated complex I activity, which is transcriptionally upregulated via the CD147‐STAT3 signaling axis. Enhanced oxidative phosphorylation (OXPHOS) and NAD+ production driven by this CD147‐NDUFS1 axis subsequently trigger the SIRT1‐DNMT1 metaboloepigenetic signaling
Xin‐Yu Fan, Wen Li, Ying Shi, Bao‐Qing Xu, Hao Wang, Ruo‐Fei Tian, Zi‐Chuan Duan, Jing Fan, Jia‐Rong Liu, Xiu‐Xuan Sun, Bin Wang, Li‐Juan Wang, Ke Wang, Shi‐Jie Wang, Xiang‐Min Yang, Hong‐Yong Cui, Zhi‐Nan Chen, Ling Li   +17 more
wiley   +1 more source

How to starve cancer cells when nutrients are abundant

Molecular & Cellular Oncology, 2020
Metabolic flexibility represents a potential point of attack for novel cancer treatments. We recently described the signaling mechanism inducing a metabolic shift in response to metformin and phenformin in leukemia and lymphoma cells.
Hamidullah Khan, Stefan M. Schieke
doaj   +1 more source

Defining the short-term effects of pharmacological 5′-AMP activated kinase modulators on mitochondrial polarization, morphology and heterogeneity [PDF]

PeerJ, 2018
Background Under aerobic growth conditions, mitochondria are the major producers of cellular ATP and crucial for the proper performance of organs and tissues.
Mohamed Kodiha, Etienne Flamant, Yi Meng Wang, Ursula Stochaj   +3 more
doaj   +2 more sources

LKB1–AMPK Signaling Pathway in Cardiovascular and Other Diseases

MedComm, Volume 7, Issue 3, March 2026.
The LKB1–AMPK pathway has a central regulatory role in various diseases. Dysfunction of this pathway can lead to pathological processes in cardiovascular diseases (atrial fibrillation, myocardial infarction, myocardial hypertrophy, atherosclerosis), metabolic diseases (diabetes and kidney disease), neurodegenerative diseases (Alzheimer's disease ...
Zhuo Chen, Qin Yang, Guo‐Wei He
wiley   +1 more source

Tandem Takeoff: Powering Tomorrow with Industrial‐Grade Perovskite/Silicon Solar Cells

Advanced Energy Materials, Volume 16, Issue 5, 4 February 2026.
Perovskite/silicon tandem solar cells have recently achieved certified power conversion efficiencies of 34.85%, far exceeding the Shockley‐Queisser limit for single‐junction silicon and standalone perovskite cells. This review highlights the latest advances in the design, integration, and optimization of perovskite top cells for monolithic tandem ...
Maria Vasilopoulou, Di Huang, Jue Gong, Faming Li, Hao Zhang, Yinqing Sun, Lin Mao, Ermioni Polydorou, Ioannis G. Aviziotis, Leonidas C. Palilis, Onurcan Kaya, Stephan Roche, Jordi Arbiol, Dimitrios Davazoglou, Emmanuel Kymakis, Lei Liu, Kuan Sun, Abd Rashid bin Mohd Yusoff, Mingzhen Liu, Mohammad Khaja Nazeeruddin   +19 more
wiley   +1 more source

Amphiregulin and Epiregulin Confer Radioresistance in Esophageal Squamous Cell Carcinoma Through Oxidative Phosphorylation

Advanced Science, Volume 13, Issue 6, 30 January 2026.
Oxidative phosphorylation (OXPHOS) activity serves as a critical metabolic determinant of radiotherapy outcomes in esophageal squamous cell carcinoma (ESCC). The CEBPB/AREG/EREG axis drives radioresistance in ESCC by reprogramming OXPHOS. AREG and EREG function as predictive biomarkers for nCRT response and prognosis of ESCC patients.
Zhang Lin, Meilian Yao, Xin Xu, Dong Zhang, Lei Xu, Ling Rong, Xiaohang Wang, Yi Duan, Chengkun Chen, Jun Gu, Yao Zhang, Qiang Liu, Qing Ye, Gaoping Cui, Yujun Hao, Xiumei Ma   +15 more
wiley   +1 more source

Metformin Downregulates the STAT Pathway and Reduces Bone Marrow Fibrosis in Primary Myelofibrosis Patients: Final Results of the Phase II FIBROMET Trial

Hematological Oncology, Volume 44, Issue 1, January 2026.
ABSTRACT Primary myelofibrosis (PMF) is a chronic myeloproliferative neoplasm characterized by the activation of the JAK‐STAT pathway. Previous evidence showed that metformin might be a possible therapeutic option for treating JAK2‐mediated myeloproliferative neoplasms.
Paula de Melo Campos, Kátia Borgia Barbosa Pagnano, Fernanda Soares Niemann, Rubia Isler Mancuso, Fernanda Isabel Della Via, Ada Congrains, Juan Luiz Coelho‐Silva, Ângela Condotta Tinoco, Guilherme Rossi Assis‐Mendonça, Leandro Luiz Lopes de Freitas, Fabiola Traina, Sara T. Olalla Saad   +11 more
wiley   +1 more source