Journal of Nanobiotechnology, 2021 Highlights Over-expression of PD-L1 after mild-photothermal therapy significantly limited its efficacy. Phenformin could effectively downregulate PD-L1 expression and inhibit tumor metastasis through AMPK activation.
Zaigang Zhou +7 more
doaj +1 more source
Disruption of BASIGIN decreases lactic acid export and sensitizes non-small cell lung cancer to biguanides independently of the LKB1 status [PDF]
, 2014 Most cancers rely on aerobic glycolysis to generate energy and metabolic intermediates. To maintain a high glycolytic rate, cells must efficiently export lactic acid through the proton-coupled monocarboxylate transporters (MCT1/4).
Baltazar, Fátima +5 more
core +2 more sources
Biomolecules, 2020 Damage to cerebral mitochondria, particularly opening of mitochondrial permeability transition pore (MPTP), is a key mechanism of ischemic brain injury, therefore, modulation of MPTP may be a potential target for a neuroprotective strategy in ischemic ...
Kristina Skemiene +5 more
doaj +1 more source
Respiratory chain complex I is related to oxidative phosphorylation in gastric cancer stem cells
STEMedicine, 2022 Background: Cancer stem cells (CSCs) are the main cause of resistance to anti-cancer drug therapy and distant metastasis of tumors, including gastric cancer. The metabolism of CSCs is an important factor in the maintenance of its stemness. This study is
Chunwei Peng, Weibiao Kang, Yunsong Li
doaj +1 more source
Molecular features of biguanides required for targeting of mitochondrial respiratory complex I and activation of AMP-kinase. [PDF]
, 2016 BACKGROUND: The biguanides are a family of drugs with diverse clinical applications. Metformin, a widely used anti-hyperglycemic biguanide, suppresses mitochondrial respiration by inhibiting respiratory complex I. Phenformin, a related anti-hyperglycemic
Agip, Ahmed-Noor A +3 more
core +1 more source
Phenformin attenuates the oxidative-nitrosative stress in the liver of rats under long-term ethanol administration [PDF]
The Ukrainian Biochemical JournalModulation of the AMP-activated protein kinase (AMPK) pathway activity is considered to be a promising option in the development of approaches to chronic alcoholic hepatitis treatment. Phenformin, which is a biguanide, has been reported to increase AMPK
A. Mykytenko +3 more
doaj +1 more source
Defective Signalling of the BRCA1 Neighbouring gene, NBR2, leads to ER-? Negative tumours in breast cancer xenograft mouse models [PDF]
Journal of Veterinary and Animal Sciences, 2022 Majority of breast and ovarian cancer treatment modalities are based on endocrine therapies like antiestrogens which are dependent on the hormone receptor status of tumours.
Dipyaman Patra +4 more
doaj +1 more source
Metabolic Profiles Associated With Metformin Efficacy in Cancer
Frontiers in Endocrinology, 2018 Metformin is one of the most commonly prescribed medications for the treatment of type 2 diabetes. Numerous reports have suggested potential anti-cancerous and cancer preventive properties of metformin, although these findings vary depending on the ...
Sylvia Andrzejewski +4 more
doaj +1 more source
Metformin: a modulator of bevacizumab activity in cancer? A case report. [PDF]
, 2015 Recurrent type I endometrial cancer ((EC)) has poor prognosis and demands novel therapeutic approaches. Bevacizumab, a VEGF-A neutralizing monoclonal antibody, has shown clinical activity in this setting. To our knowledge, however, although some diabetic
Aliberti, C +7 more
core +1 more source
Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides [PDF]
, 2013 As the concentrations of highly consumed nutrients, particularly glucose, are generally lower in tumours than in normal tissues1,2, cancer cells must adapt their metabolism to the tumour microenvironment. A better understanding of these adaptations might
A DeCensi +36 more
core +3 more sources