Results 61 to 70 of about 6,979 (257)

How to starve cancer cells when nutrients are abundant

Molecular & Cellular Oncology, 2020
Metabolic flexibility represents a potential point of attack for novel cancer treatments. We recently described the signaling mechanism inducing a metabolic shift in response to metformin and phenformin in leukemia and lymphoma cells.
Hamidullah Khan, Stefan M. Schieke
doaj   +1 more source

AMP-activated protein kinase inhibits K_v1.5 channel currents of pulmonary arterial myocytes in response to hypoxia and inhibition of mitochondrial oxidative phosphorylation [PDF]

, 2016
KEY POINTS: Progression of hypoxic pulmonary hypertension is thought to be due, in part, to suppression of voltage‐gated potassium channels (K(v)) in pulmonary arterial smooth muscle by hypoxia, although the precise molecular mechanisms have been unclear.
A. Mark Evans, Amira D. Mahmoud, Andersen, Archer, Archer, Bain, Bartsch, Blom, Bonnet, Bonnet, Brevnova, Burg, Chang, Cheung, Cidad, Cidad, Comes, Corton, D. Grahame Hardie, David, David Fedida, Dipp, Egan, Ekhterae, Ekhterae, El-Mir, Euler, Evans, Evans, Evans, Fiona A. Ross, Firth, Firth, Firth, Gomez-Galeno, Goncharov, Goransson, Gowans, Hardie, Hardie, Hardie, Hardie, Hawley, Holmes, Hunter, Ibe, Ikematsu, Javier Moral-Sanz, Jodene Eldstrom, Jones, Kato, Krick, Kwak, Lahm, Lang, Lu, Macias, Martens, Mia, Michelakis, Michelakis, Moral-Sanz, Morales-Cano, Moudgil, Olschewski, Owen, Platoshyn, Platoshyn, Platoshyn, Post, Pozeg, Prieto-Lloret, Remillard, Robertson, Ross, Ross, Sakamoto, Scott, Scott, Smirnov, Sweeney, Tipparaju, Vallejo-Gracia, Wang, Williams, Wilson, Xiao, Yuan, Yuan   +88 more
core   +3 more sources

Tandem Takeoff: Powering Tomorrow with Industrial‐Grade Perovskite/Silicon Solar Cells

Advanced Energy Materials, Volume 16, Issue 5, 4 February 2026.
Perovskite/silicon tandem solar cells have recently achieved certified power conversion efficiencies of 34.85%, far exceeding the Shockley‐Queisser limit for single‐junction silicon and standalone perovskite cells. This review highlights the latest advances in the design, integration, and optimization of perovskite top cells for monolithic tandem ...
Maria Vasilopoulou, Di Huang, Jue Gong, Faming Li, Hao Zhang, Yinqing Sun, Lin Mao, Ermioni Polydorou, Ioannis G. Aviziotis, Leonidas C. Palilis, Onurcan Kaya, Stephan Roche, Jordi Arbiol, Dimitrios Davazoglou, Emmanuel Kymakis, Lei Liu, Kuan Sun, Abd Rashid bin Mohd Yusoff, Mingzhen Liu, Mohammad Khaja Nazeeruddin   +19 more
wiley   +1 more source

Defining the short-term effects of pharmacological 5′-AMP activated kinase modulators on mitochondrial polarization, morphology and heterogeneity [PDF]

PeerJ, 2018
Background Under aerobic growth conditions, mitochondria are the major producers of cellular ATP and crucial for the proper performance of organs and tissues.
Mohamed Kodiha, Etienne Flamant, Yi Meng Wang, Ursula Stochaj   +3 more
doaj   +2 more sources

A systematic review of performance-enhancing pharmacologicals and biotechnologies in the Army [PDF]

, 2018
INTRODUCTION: In 2015, the Australian Army commissioned a systematic review to assess the evidence on effectiveness and safety of pharmacological and biotechnological products for cognitive enhancement specifically in Army personnel.METHODS: Searches for
Ayson, Mark, Hunter, K E, Ko, Henry, Scott, A M, Willson, M L   +4 more
core   +1 more source

Amphiregulin and Epiregulin Confer Radioresistance in Esophageal Squamous Cell Carcinoma Through Oxidative Phosphorylation

Advanced Science, Volume 13, Issue 6, 30 January 2026.
Oxidative phosphorylation (OXPHOS) activity serves as a critical metabolic determinant of radiotherapy outcomes in esophageal squamous cell carcinoma (ESCC). The CEBPB/AREG/EREG axis drives radioresistance in ESCC by reprogramming OXPHOS. AREG and EREG function as predictive biomarkers for nCRT response and prognosis of ESCC patients.
Zhang Lin, Meilian Yao, Xin Xu, Dong Zhang, Lei Xu, Ling Rong, Xiaohang Wang, Yi Duan, Chengkun Chen, Jun Gu, Yao Zhang, Qiang Liu, Qing Ye, Gaoping Cui, Yujun Hao, Xiumei Ma   +15 more
wiley   +1 more source

PT-1 selectively activates AMPK-γ1 complexes in mouse skeletal muscle, but activates all three γ subunit complexes in cultured human cells by inhibiting the respiratory chain [PDF]

, 2015
AMP-activated protein kinase (AMPK) occurs as heterotrimeric complexes in which a catalytic subunit (α 1/α 2) is bound to one of two β subunits (β 1/β 2) and one of three γ subunits (γ 1/γ 2/γ 3).
Arad, Barnes, Barre, Birk, Carling, Chen, Cheung, Corton, Crute, D. Grahame Hardie, Davies, Egan, Erik A. Richter, Fiona A. Ross, Frosig, Fullerton, Gollob, Goransson, Gowans, Graeme J. Gowans, Gregor, Gwinn, Hardie, Hardie, Hardie, Hardie, Hawley, Hawley, Hawley, Hunter, Jensen, Jonas R. Knudsen, Jorgensen, Jørgensen, Kim, Kjobsted, Lai, Li, Lykke Sylow, Maximilian Kleinert, Mu, Pang, Pang, Pehmoller, Pinter, Pinter, Scott, Steinberg, Steinberg, Steinberg, Taylor, Thomas E. Jensen, Treebak, Treebak, Treebak, Tsou, Turner, Woods, Xiao, Xiao, Xiao, Yu, Zadra   +62 more
core   +2 more sources

Metformin Downregulates the STAT Pathway and Reduces Bone Marrow Fibrosis in Primary Myelofibrosis Patients: Final Results of the Phase II FIBROMET Trial

Hematological Oncology, Volume 44, Issue 1, January 2026.
ABSTRACT Primary myelofibrosis (PMF) is a chronic myeloproliferative neoplasm characterized by the activation of the JAK‐STAT pathway. Previous evidence showed that metformin might be a possible therapeutic option for treating JAK2‐mediated myeloproliferative neoplasms.
Paula de Melo Campos, Kátia Borgia Barbosa Pagnano, Fernanda Soares Niemann, Rubia Isler Mancuso, Fernanda Isabel Della Via, Ada Congrains, Juan Luiz Coelho‐Silva, Ângela Condotta Tinoco, Guilherme Rossi Assis‐Mendonça, Leandro Luiz Lopes de Freitas, Fabiola Traina, Sara T. Olalla Saad   +11 more
wiley   +1 more source

LKB1 and AMPK and the cancer-metabolism link - ten years after [PDF]

, 2013
The identification of a complex containing the tumor suppressor LKB1 as the critical upstream kinase required for the activation of AMP-activated protein kinase (AMPK) by metabolic stress was reported in an article in Journal of Biology in 2003.
A Decensi, A Hemminki, A Mora, A Street, A Woods, A Woods, A Woods, AF Baas, AK Al-Hakim, AS Marsin, AS Marsin, B Faubert, B Xiao, B Xiao, B Zheng, C Algire, C Canto, CM Sutherland, CW Lee, CW Song, D Carling, D Grahame Hardie, Dario R Alessi, DB Shackelford, DB Shackelford, DE Jenne, DG Hardie, DG Hardie, DG Hardie, DM Gwinn, DR Alessi, G Manning, G Zhou, GM Merrill, GV Thomas, H Ji, HA Hirsch, HM O'Neill, J Boudeau, J Liang, J Mankouri, JM Evans, JM Kyriakis, JM Lizcano, JS Oakhill, K Barnes, K Imamura, K Inoki, K Kato, K Sakamoto, KI Mitchelhill, L Liu, LA Yeh, M Foretz, M Jaleel, M Pollak, M Sanchez-Cespedes, MG Vander Heiden, MR Owen, N Nath, N Stahmann, O Warburg, P Tamas, RG Jones, RJ Shaw, RL Hurley, RR Russell, S Fogarty, S Hadad, S Horman, S Niraula, S Suissa, SA Hawley, SA Hawley, SA Hawley, SA Hawley, SA Hawley, SH Koo, SM Jeon, SN Wingo, SP Davies, SP Hong, TL Yuan, TS Ingebritsen, U Andersson, W Liu, WW Winder, WW Winder, WW Winder, X Huang, Y Yang   +90 more
core   +4 more sources

Combination of metformin and phenformin synergistically inhibits proliferation and hTERT expression in human breast cancer cells [PDF]

Iranian Journal of Basic Medical Sciences, 2018
Objective(s): Breast cancer remains a global challenge, and further chemopreventive therapies are still immediately required. Emerging evidence has revealed the potent anti-cancer effects of biguanides, Metformin (MET) and phenformin (PHE).
Davoud Jafari-Gharabaghlou, Younes Pilehvar-Soltanahmadi, Mehdi Dadashpour, Ali Mota, Soheila Vafajouy-Jamshidi, Leila Faramarzi, Sara Rasouli, Nosratollah Zarghami   +7 more
doaj   +1 more source