Results 61 to 70 of about 856 (149)

Tandem Takeoff: Powering Tomorrow with Industrial‐Grade Perovskite/Silicon Solar Cells

Advanced Energy Materials, Volume 16, Issue 5, 4 February 2026.
Perovskite/silicon tandem solar cells have recently achieved certified power conversion efficiencies of 34.85%, far exceeding the Shockley‐Queisser limit for single‐junction silicon and standalone perovskite cells. This review highlights the latest advances in the design, integration, and optimization of perovskite top cells for monolithic tandem ...
Maria Vasilopoulou, Di Huang, Jue Gong, Faming Li, Hao Zhang, Yinqing Sun, Lin Mao, Ermioni Polydorou, Ioannis G. Aviziotis, Leonidas C. Palilis, Onurcan Kaya, Stephan Roche, Jordi Arbiol, Dimitrios Davazoglou, Emmanuel Kymakis, Lei Liu, Kuan Sun, Abd Rashid bin Mohd Yusoff, Mingzhen Liu, Mohammad Khaja Nazeeruddin   +19 more
wiley   +1 more source

Amphiregulin and Epiregulin Confer Radioresistance in Esophageal Squamous Cell Carcinoma Through Oxidative Phosphorylation

Advanced Science, Volume 13, Issue 6, 30 January 2026.
Oxidative phosphorylation (OXPHOS) activity serves as a critical metabolic determinant of radiotherapy outcomes in esophageal squamous cell carcinoma (ESCC). The CEBPB/AREG/EREG axis drives radioresistance in ESCC by reprogramming OXPHOS. AREG and EREG function as predictive biomarkers for nCRT response and prognosis of ESCC patients.
Zhang Lin, Meilian Yao, Xin Xu, Dong Zhang, Lei Xu, Ling Rong, Xiaohang Wang, Yi Duan, Chengkun Chen, Jun Gu, Yao Zhang, Qiang Liu, Qing Ye, Gaoping Cui, Yujun Hao, Xiumei Ma   +15 more
wiley   +1 more source

Metformin Downregulates the STAT Pathway and Reduces Bone Marrow Fibrosis in Primary Myelofibrosis Patients: Final Results of the Phase II FIBROMET Trial

Hematological Oncology, Volume 44, Issue 1, January 2026.
ABSTRACT Primary myelofibrosis (PMF) is a chronic myeloproliferative neoplasm characterized by the activation of the JAK‐STAT pathway. Previous evidence showed that metformin might be a possible therapeutic option for treating JAK2‐mediated myeloproliferative neoplasms.
Paula de Melo Campos, Kátia Borgia Barbosa Pagnano, Fernanda Soares Niemann, Rubia Isler Mancuso, Fernanda Isabel Della Via, Ada Congrains, Juan Luiz Coelho‐Silva, Ângela Condotta Tinoco, Guilherme Rossi Assis‐Mendonça, Leandro Luiz Lopes de Freitas, Fabiola Traina, Sara T. Olalla Saad   +11 more
wiley   +1 more source

Combination of metformin and phenformin synergistically inhibits proliferation and hTERT expression in human breast cancer cells [PDF]

Iranian Journal of Basic Medical Sciences, 2018
Objective(s): Breast cancer remains a global challenge, and further chemopreventive therapies are still immediately required. Emerging evidence has revealed the potent anti-cancer effects of biguanides, Metformin (MET) and phenformin (PHE).
Davoud Jafari-Gharabaghlou, Younes Pilehvar-Soltanahmadi, Mehdi Dadashpour, Ali Mota, Soheila Vafajouy-Jamshidi, Leila Faramarzi, Sara Rasouli, Nosratollah Zarghami   +7 more
doaj   +1 more source

Therapeutic potential of the metabolic modulator phenformin in targeting the stem cell compartment in melanoma [PDF]

, 2016
Melanoma is the most dangerous and treatment-resistant skin cancer. Tumor resistance and recurrence are due to the persistence in the patient of aggressive cells with stem cell features, the cancer stem cells (CSC).
Albini, Adriana, Grisendi, Giulia, Argenziano, Giuseppe, Romagnani, Alessandra, Ciarrocchi, Alessia, Dallaglio, Katiuscia, Petrachi, Tiziana, Longo, Caterina, Dominici, Massimo   +8 more
core   +1 more source

Guanidine‐Based Ligands in Bioinorganic Chemistry: Coordination Modes and Applications in Anticancer Metallodrugs

Bioinorganic Chemistry and Applications, Volume 2026, Issue 1, 2026.
Guanidine‐containing molecules represent a versatile class of nitrogen‐rich compounds whose unique structural and physicochemical features underpin a rich and tunable coordination chemistry. Their capacity to act as strong donor ligands, stabilize a variety of metal centers in different oxidation states, and access multiple coordination modes has ...
Almudena del Campo-Balguerías, Alberto Ocaña, Iván Bravo, Carlos Alonso-Moreno, Franc Perdih   +4 more
wiley   +1 more source

Model of phenformin and oxamate activity in tumor cells.

, 2014
We propose that the two drugs act synergistically by simultaneous inhibition of complex I and LDH. Phenformin increases ROS production by inhibiting mitochondria complex I.
Yuh-Seog Jung (511907), Joon Young Choi (511908), W. Keith Miskimins (511903), Hyun Joo Ahn (511904), Ji Yeon Kim (511905), Sun Ryu (511906)   +5 more
core   +1 more source

Phenformin as an Anticancer Agent: Challenges and Prospects [PDF]

, 2019
Currently, there is increasing evidence linking diabetes mellitus (especially type 2 diabetes mellitus) with carcinogenesis through various biological processes, such as fat-induced chronic inflammation, hyperglycemia, hyperinsulinemia, and ...
Mª Eugenia García Rubiño, Boulaiz, Houria, Gloria Ruiz Alcalá, Carrillo, Esmeralda, Ruiz Alcalá, Gloria, Marchal Corrales, Juan Antonio, García Rubiño, María Eugenia, Juan A. Marchal, Carrillo Delgado, Esmeralda Esperanza, Domínguez Martín, Alicia, Domínguez-Martín, Alicia, A Marchal, Juan, Esmeralda Carrillo, Alicia Domínguez-Martín, Boulaiz Tassi, Houria, Houria Boulaiz, García Rubiño, Mª Eugenia   +16 more
core   +1 more source

Ligand‐Based Pharmacophore Mapping and Virtual Screening for the Search of Biguanide‐Like Molecules With Antidiabetic Potentials Targeting Liver Kinase B1

Biochemistry Research International, Volume 2026, Issue 1, 2026.
Type 2 diabetes mellitus (T2DM) is a state where the body’s glucose metabolism is compromised. AMP‐activated protein kinase, or AMPK, has an important part to play in glucose metabolism, and the liver kinase B1 (LKB1) protein functions as a major upstream kinase for AMPK activation, thereby making it appealing therapeutic targets for treating and ...
Rumman Reza, Md. Nazmus Samdani, Niaz Morshed, Raihana Haque Jebin, Imtiaz Ahmed, Md. Selim Reza, Harleen Khatra   +6 more
wiley   +1 more source

Metabolic reprogramming in diffuse intrinsic pontine gliomas (DIPG): dual inhibition of mitochondrial oxidative phosphorylation and lactate metabolism to enhance anti-tumor and radiosensitizing effects in DIPG cells

Cancer & Metabolism
Background Diffuse midline gliomas (DMGs), including diffuse intrinsic pontine gliomas (DIPGs), are universally fatal pediatric brain tumors with no effective treatments.
Han Shen, Quy-Susan Huynh, Faiqa Mudassar, Cecilia Chang, Brian Gloss, Prunella Ing, Shiyong Ma, Harriet Gee, Eric Hau, Kristina M. Cook   +9 more
doaj   +1 more source