Results 51 to 60 of about 6,979 (257)

STAT1 potentiates oxidative stress revealing a targetable vulnerability that increases phenformin efficacy in breast cancer

Nature Communications, 2021
Complex I inhibition induces oxidative stress leading to cancer cell cytotoxicity. Here, the authors show, in breast cancer models, that inflammatory mediators can potentiate complex I inhibitor phenformin cytotoxicity through STAT1-mediated ...
Stephanie P. Totten, Young Kyuen Im, Eduardo Cepeda Cañedo, Ouafa Najyb, Alice Nguyen, Steven Hébert, Ryuhjin Ahn, Kyle Lewis, Benjamin Lebeau, Rachel La Selva, Valérie Sabourin, Constanza Martínez, Paul Savage, Hellen Kuasne, Daina Avizonis, Nancy Santos Martínez, Catherine Chabot, Adriana Aguilar-Mahecha, Marie-Line Goulet, Matthew Dankner, Michael Witcher, Kevin Petrecca, Mark Basik, Michael Pollak, Ivan Topisirovic, Rongtuan Lin, Peter M. Siegel, Claudia L. Kleinman, Morag Park, Julie St-Pierre, Josie Ursini-Siegel   +30 more
doaj   +1 more source

Repositioning of Verrucosidin, a purported inhibitor of chaperone protein GRP78, as an inhibitor of mitochondrial electron transport chain complex I. [PDF]

, 2013
Verrucosidin (VCD) belongs to a group of fungal metabolites that were identified in screening programs to detect molecules that preferentially kill cancer cells under glucose-deprived conditions.
Chen, Thomas C, Gonzalez, Reyna, Hofman, Florence M, Louie, Stan G, Pao, Peng-Wen, Pirrung, Michael C, Schönthal, Axel H, Sharma, Natasha, Thomas, Simmy   +8 more
core   +7 more sources

Protocols for analyzing metabolic derangements caused by increased NADH/NAD+ ratio in cell lines and in mice

STAR Protocols, 2022
Summary: Mitochondrial electron transport chain (ETC) dysfunction elevates the NADH/NAD+ ratio to cause metabolic derangements. Here we describe a protocol to measure the NADH/NAD+ ratio and analyze the rewiring of glucose metabolism using [4-2H]-glucose,
Shanshan Liu, Yan Ma, Hui Jiang
doaj   +1 more source

NDUFS1‐Mediated Mitochondrial Complex I Activity Maintains Pancreatic Cancer Stemness by Promoting PAX2 Hypomethylation

MedComm, Volume 7, Issue 4, April 2026.
Pancreatic cancer stem cells (CSCs) maintain stemness and tumorigenicity through NDUFS1‐mediated complex I activity, which is transcriptionally upregulated via the CD147‐STAT3 signaling axis. Enhanced oxidative phosphorylation (OXPHOS) and NAD+ production driven by this CD147‐NDUFS1 axis subsequently trigger the SIRT1‐DNMT1 metaboloepigenetic signaling
Xin‐Yu Fan, Wen Li, Ying Shi, Bao‐Qing Xu, Hao Wang, Ruo‐Fei Tian, Zi‐Chuan Duan, Jing Fan, Jia‐Rong Liu, Xiu‐Xuan Sun, Bin Wang, Li‐Juan Wang, Ke Wang, Shi‐Jie Wang, Xiang‐Min Yang, Hong‐Yong Cui, Zhi‐Nan Chen, Ling Li   +17 more
wiley   +1 more source

AMPK:a target for drugs and natural products with effects on both diabetes and cancer [PDF]

, 2013
The AMP-activated protein kinase (AMPK) is a highly conserved sensor of cellular energy that appears to have arisen at an early stage during eukaryotic evolution.
Chen, Cool, Corton, D. G. Hardie, Davies, Davies, El-Mir, Foretz, Greer, Hardie, Hardie, Hawley, Hawley, Hawley, Hawley, Huang, Hwang, Imamura, Jaleel, Ji, Jones, Liang, Lin, Lochhead, Lowell, Miners, Mooney, Musi, Oakhill, Rothwell, Rothwell, Scott, Stahmann, Suissa, Thaler, Timmers, Vara, Vincent, Woods, Woods, Xiao, Xiao, Yang, Yin   +43 more
core   +4 more sources

Nanog maintains stemness of Lkb1‐deficient lung adenocarcinoma and prevents gastric differentiation

EMBO Molecular Medicine, 2021
Growing evidence supports that LKB1‐deficient KRAS‐driven lung tumors represent a unique therapeutic challenge, displaying strong cancer plasticity that promotes lineage conversion and drug resistance.
Xinyuan Tong, Yueqing Chen, Xinsheng Zhu, Yi Ye, Yun Xue, Rui Wang, Yijun Gao, Wenjing Zhang, Weiqiang Gao, Lei Xiao, Haiquan Chen, Peng Zhang, Hongbin Ji   +12 more
doaj   +1 more source

Ampk regulates IgD expression but not energy stress with B cell activation. [PDF]

, 2019
Ampk is an energy gatekeeper that responds to decreases in ATP by inhibiting energy-consuming anabolic processes and promoting energy-generating catabolic processes.
Ahsan, Fasih M, Braas, Daniel, Graeber, Thomas G, Hong, Jason S, Kim, Diane NH, Minasyan, Aspram, Teitell, Michael A, Ten Hoeve, Johanna, Waters, Lynnea R, Zangle, Thomas A   +9 more
core   +1 more source

Single‐Cell Transcriptomic Analysis of Chemotherapy‐Induced Changes in Osteosarcoma With a Pyroptosis‐Related Gene‐Based Prognostic Model

Journal of Cellular and Molecular Medicine, Volume 30, Issue 7, April 2026.
ABSTRACT Osteosarcoma, the most common primary malignant bone tumour, presents significant treatment challenges due to its complex tumour microenvironment and the development of chemoresistance. This study employs single‐cell transcriptomics to investigate chemotherapy‐induced changes in osteosarcoma at both the cellular and molecular levels.
Tao Jin, Lei Dong, Wang Kai, Ziyang Yu, Guoyong Yu, Weifeng Liu   +5 more
wiley   +1 more source

Metformin use in pregnancy: promises and uncertainties [PDF]

, 2017
Metformin has been prescribed in pregnancy for over 40 years; for much of this time, use has been limited both in numbers and geographically, and the evidence base has been confined to observational studies.
Lindsay, Robert S., Loeken, Mary R.
core   +1 more source

LKB1–AMPK Signaling Pathway in Cardiovascular and Other Diseases

MedComm, Volume 7, Issue 3, March 2026.
The LKB1–AMPK pathway has a central regulatory role in various diseases. Dysfunction of this pathway can lead to pathological processes in cardiovascular diseases (atrial fibrillation, myocardial infarction, myocardial hypertrophy, atherosclerosis), metabolic diseases (diabetes and kidney disease), neurodegenerative diseases (Alzheimer's disease ...
Zhuo Chen, Qin Yang, Guo‐Wei He
wiley   +1 more source