Results 51 to 60 of about 856 (149)
STAR Protocols, 2022 Summary: Mitochondrial electron transport chain (ETC) dysfunction elevates the NADH/NAD+ ratio to cause metabolic derangements. Here we describe a protocol to measure the NADH/NAD+ ratio and analyze the rewiring of glucose metabolism using [4-2H]-glucose,
Shanshan Liu, Yan Ma, Hui Jiang
doaj +1 more source
In vitro interactions of phenformin with serum lipoproteins and consequences thereof
, 1977 Turbidity developed when phenformin was added to human serum; this turbidity increased in a sigmoidal fashion with rising concentrations of phenformin (5-50 nmole/1). Centrifugation produced clearing of the solution, with collection of particulate matter
Cham B.E.
core +1 more source
Defect engineering for highly efficient and stable perovskite top cells for Si tandems
Bulletin of the Korean Chemical Society, Volume 47, Issue 5, Page 527-550, May 2026.Defect passivation in wide‐bandgap perovskites is essential for enabling high‐efficiency and stable perovskite/Si tandem solar cells. Bulk, surface, and buried‐interface passivation strategies focus on suppressing nonradiative recombination, ion migration, and halide segregation, thereby clarifying critical design principles for next‐generation tandem ...
Ju Yeong Hong +2 more
wiley +1 more source
MedComm, Volume 7, Issue 4, April 2026.Pancreatic cancer stem cells (CSCs) maintain stemness and tumorigenicity through NDUFS1‐mediated complex I activity, which is transcriptionally upregulated via the CD147‐STAT3 signaling axis. Enhanced oxidative phosphorylation (OXPHOS) and NAD+ production driven by this CD147‐NDUFS1 axis subsequently trigger the SIRT1‐DNMT1 metaboloepigenetic signaling
Xin‐Yu Fan +17 more
wiley +1 more source
How to starve cancer cells when nutrients are abundant
Molecular & Cellular Oncology, 2020 Metabolic flexibility represents a potential point of attack for novel cancer treatments. We recently described the signaling mechanism inducing a metabolic shift in response to metformin and phenformin in leukemia and lymphoma cells.
Hamidullah Khan, Stefan M. Schieke
doaj +1 more source
Phenformin promotes breast cancer apoptosis.
, 2015 (A) MCF7, ZR-75-1, MDA-MB-231 and SUM1315 cells treated with or without phenformin were double-stained with Annexin V and PI, and then analyzed by flow cytometry. (B) The percentages of Annexin V+/PI- cells(early apoptosis) were plotted.
Chenghao Liu (761535) +5 more
core +1 more source
Journal of Cellular and Molecular Medicine, Volume 30, Issue 7, April 2026.ABSTRACT Osteosarcoma, the most common primary malignant bone tumour, presents significant treatment challenges due to its complex tumour microenvironment and the development of chemoresistance. This study employs single‐cell transcriptomics to investigate chemotherapy‐induced changes in osteosarcoma at both the cellular and molecular levels.
Tao Jin +5 more
wiley +1 more source
Defining the short-term effects of pharmacological 5′-AMP activated kinase modulators on mitochondrial polarization, morphology and heterogeneity [PDF]
PeerJ, 2018 Background Under aerobic growth conditions, mitochondria are the major producers of cellular ATP and crucial for the proper performance of organs and tissues.
Mohamed Kodiha +3 more
doaj +2 more sources
Defective hydroxylation of phenformin as a determinant of drug toxicity
, 1981 The kinetics of phenformin and its metabolite, p-hydroxyphenethylbiguanide, was studied in eight diabetic patients with varying degrees of renal impairment.
A. Negri +7 more
core +1 more source
LKB1–AMPK Signaling Pathway in Cardiovascular and Other Diseases
MedComm, Volume 7, Issue 3, March 2026.The LKB1–AMPK pathway has a central regulatory role in various diseases. Dysfunction of this pathway can lead to pathological processes in cardiovascular diseases (atrial fibrillation, myocardial infarction, myocardial hypertrophy, atherosclerosis), metabolic diseases (diabetes and kidney disease), neurodegenerative diseases (Alzheimer's disease ...
Zhuo Chen, Qin Yang, Guo‐Wei He
wiley +1 more source