Results 31 to 40 of about 3,344 (169)

Antifibrin action of phenformin [PDF]

Diabetologia, 1975
Effects of phenformin on blood sugar, serum triglyceride, thrombin time, euglobulin clot lysis time and cardiovascular complications were studied in maturity onset diabetes and in atherosclerotic patients with or without diabetes, for a period of 14-18 months.
R N, Banerjee, V, Kumar, S R, Rao, A L, Sahni, M, Arya, J, Bardhan   +5 more
openaire   +2 more sources

Phenformin attenuates the oxidative-nitrosative stress in the liver of rats under long-term ethanol administration [PDF]

The Ukrainian Biochemical Journal
Modulation of the AMP-activated protein kinase (AMPK) pathway activity is considered to be a promi­sing option in the development of approaches to chronic alcoholic hepatitis treatment. Phenformin, which is a biguanide, has been reported to increase AMPK
A. Mykytenko, O. Akimov, G. Yeroshenko, K. Neporada   +3 more
doaj   +1 more source

Comparison of Effects of Metformin, Phenformin, and Inhibitors of Mitochondrial Complex I on Mitochondrial Permeability Transition and Ischemic Brain Injury

Biomolecules, 2020
Damage to cerebral mitochondria, particularly opening of mitochondrial permeability transition pore (MPTP), is a key mechanism of ischemic brain injury, therefore, modulation of MPTP may be a potential target for a neuroprotective strategy in ischemic ...
Kristina Skemiene, Evelina Rekuviene, Aiste Jekabsone, Paulius Cizas, Ramune Morkuniene, Vilmante Borutaite   +5 more
doaj   +1 more source

Respiratory chain complex I is related to oxidative phosphorylation in gastric cancer stem cells

STEMedicine, 2022
Background: Cancer stem cells (CSCs) are the main cause of resistance to anti-cancer drug therapy and distant metastasis of tumors, including gastric cancer. The metabolism of CSCs is an important factor in the maintenance of its stemness. This study is
Chunwei Peng, Weibiao Kang, Yunsong Li
doaj   +1 more source

Metabolic Profiles Associated With Metformin Efficacy in Cancer

Frontiers in Endocrinology, 2018
Metformin is one of the most commonly prescribed medications for the treatment of type 2 diabetes. Numerous reports have suggested potential anti-cancerous and cancer preventive properties of metformin, although these findings vary depending on the ...
Sylvia Andrzejewski, Sylvia Andrzejewski, Peter M. Siegel, Peter M. Siegel, Julie St-Pierre   +4 more
doaj   +1 more source

Dual Inhibition of Pirarubicin-Induced AKT and ERK Activations by Phenformin Sensitively Suppresses Bladder Cancer Growth

Frontiers in Pharmacology, 2019
Activations of Akt or ERK pathway induced by clinical drugs promote therapeutic failure due to decrease of drug response, and no available strategies have been developed to solve these problems.
Mei Peng, Mei Peng, Jun Deng, Sichun Zhou, Di Xiao, Jiahui Long, Nan Zhang, Caimei He, Miao Mo, Xiaoping Yang   +9 more
doaj   +1 more source

Guanidine‐Based Ligands in Bioinorganic Chemistry: Coordination Modes and Applications in Anticancer Metallodrugs [PDF]

Bioinorg Chem Appl
Guanidine‐containing molecules represent a versatile class of nitrogen‐rich compounds whose unique structural and physicochemical features underpin a rich and tunable coordination chemistry. Their capacity to act as strong donor ligands, stabilize a variety of metal centers in different oxidation states, and access multiple coordination modes has ...
del Campo-Balguerías A, Ocaña A, Bravo I, Alonso-Moreno C.   +3 more
europepmc   +2 more sources

STAT1 potentiates oxidative stress revealing a targetable vulnerability that increases phenformin efficacy in breast cancer

Nature Communications, 2021
Complex I inhibition induces oxidative stress leading to cancer cell cytotoxicity. Here, the authors show, in breast cancer models, that inflammatory mediators can potentiate complex I inhibitor phenformin cytotoxicity through STAT1-mediated ...
Stephanie P. Totten, Young Kyuen Im, Eduardo Cepeda Cañedo, Ouafa Najyb, Alice Nguyen, Steven Hébert, Ryuhjin Ahn, Kyle Lewis, Benjamin Lebeau, Rachel La Selva, Valérie Sabourin, Constanza Martínez, Paul Savage, Hellen Kuasne, Daina Avizonis, Nancy Santos Martínez, Catherine Chabot, Adriana Aguilar-Mahecha, Marie-Line Goulet, Matthew Dankner, Michael Witcher, Kevin Petrecca, Mark Basik, Michael Pollak, Ivan Topisirovic, Rongtuan Lin, Peter M. Siegel, Claudia L. Kleinman, Morag Park, Julie St-Pierre, Josie Ursini-Siegel   +30 more
doaj   +1 more source

Beyond Glycolysis: Targeting Non‐Glycolytic Metabolic Pathways in Brain Tumors for Therapeutic Innovation: A Narrative Review

Health Science Reports, Volume 9, Issue 6, June 2026.
ABSTRACT Background and Aims Metabolic reprogramming is a hallmark of brain tumors, extending beyond the classical Warburg effect. While glycolysis has been extensively studied, gliomas and pediatric high‐grade brain cancers demonstrate remarkable metabolic plasticity.
Iffat Islam Mayesha, Zubaier Ahmed, Ammarah Laaika Mohiuddin, Faiza Fairuz Muskan, Saiful Islam, Sharmin Jahan Sumaya   +5 more
wiley   +1 more source

Mitochondrial reprogramming in lung cancer: a therapeutic vulnerability and a strategy for reversing drug resistance

The Journal of Pathology, Volume 269, Issue 2, Page 149-163, June 2026.
Abstract The conceptualization of mitochondria, previously restricted to their function as cellular ‘powerhouses’, has evolved to recognize their function as central coordinating hubs for the orchestration of cancer cell metabolism, signaling, and fate determination.
Woo Hyun Park
wiley   +1 more source