Results 31 to 40 of about 856 (149)

Antifibrin action of phenformin [PDF]

Diabetologia, 1975
Effects of phenformin on blood sugar, serum triglyceride, thrombin time, euglobulin clot lysis time and cardiovascular complications were studied in maturity onset diabetes and in atherosclerotic patients with or without diabetes, for a period of 14-18 months.
R N, Banerjee, V, Kumar, S R, Rao, A L, Sahni, M, Arya, J, Bardhan   +5 more
openaire   +2 more sources

Rapid detection of the metformin illegally added of in TCM and health food by TLC-IR

Pakistan Journal of Pharmaceutical Sciences, 2020
Based on TLC-IR, the study established an effective method for rapid detection of metformin illegally added in hypoglycemic traditional Chinese medicine and health food products. 12 batches of hypoglycemic traditional Chinese medicine and health products
Zhang Honglian, Li Li, Wang Huiyu, Sun Jikai, Li Hongling, Dong Wei, Zhang Meijuan   +6 more
doaj   +1 more source

Selectively down-regulated PD-L1 by albumin-phenformin nanoparticles mediated mitochondrial dysfunction to stimulate tumor-specific immunological response for enhanced mild-temperature photothermal efficacy

Journal of Nanobiotechnology, 2021
Highlights Over-expression of PD-L1 after mild-photothermal therapy significantly limited its efficacy. Phenformin could effectively downregulate PD-L1 expression and inhibit tumor metastasis through AMPK activation.
Zaigang Zhou, Ning Jiang, Jiashe Chen, Chunjuan Zheng, Yuanyuan Guo, Ruirong Ye, Ruogu Qi, Jianliang Shen   +7 more
doaj   +1 more source

Phenformin attenuates the oxidative-nitrosative stress in the liver of rats under long-term ethanol administration [PDF]

The Ukrainian Biochemical Journal
Modulation of the AMP-activated protein kinase (AMPK) pathway activity is considered to be a promi­sing option in the development of approaches to chronic alcoholic hepatitis treatment. Phenformin, which is a biguanide, has been reported to increase AMPK
A. Mykytenko, O. Akimov, G. Yeroshenko, K. Neporada   +3 more
doaj   +1 more source

Comparison of Effects of Metformin, Phenformin, and Inhibitors of Mitochondrial Complex I on Mitochondrial Permeability Transition and Ischemic Brain Injury

Biomolecules, 2020
Damage to cerebral mitochondria, particularly opening of mitochondrial permeability transition pore (MPTP), is a key mechanism of ischemic brain injury, therefore, modulation of MPTP may be a potential target for a neuroprotective strategy in ischemic ...
Kristina Skemiene, Evelina Rekuviene, Aiste Jekabsone, Paulius Cizas, Ramune Morkuniene, Vilmante Borutaite   +5 more
doaj   +1 more source

Respiratory chain complex I is related to oxidative phosphorylation in gastric cancer stem cells

STEMedicine, 2022
Background: Cancer stem cells (CSCs) are the main cause of resistance to anti-cancer drug therapy and distant metastasis of tumors, including gastric cancer. The metabolism of CSCs is an important factor in the maintenance of its stemness. This study is
Chunwei Peng, Weibiao Kang, Yunsong Li
doaj   +1 more source

Metabolic Profiles Associated With Metformin Efficacy in Cancer

Frontiers in Endocrinology, 2018
Metformin is one of the most commonly prescribed medications for the treatment of type 2 diabetes. Numerous reports have suggested potential anti-cancerous and cancer preventive properties of metformin, although these findings vary depending on the ...
Sylvia Andrzejewski, Sylvia Andrzejewski, Peter M. Siegel, Peter M. Siegel, Julie St-Pierre   +4 more
doaj   +1 more source

DESIGN AND CHARACTERISATION OF TRANSDERMAL PATCHES OF PHENFORMIN HYDROCHLORIDE [PDF]

, 2017
Objective: In present work was designed to develop suitable transdermal matrix patches of Phenformin hydrochloride using various hydrophilic (HPMC) and hydrophobic (EUDRAGID) polymers as matrix formers.Methods: Transdermal patches containing Phenformin ...
Pratik Swarup Das, Puja Saha
core   +3 more sources

Dual Inhibition of Pirarubicin-Induced AKT and ERK Activations by Phenformin Sensitively Suppresses Bladder Cancer Growth

Frontiers in Pharmacology, 2019
Activations of Akt or ERK pathway induced by clinical drugs promote therapeutic failure due to decrease of drug response, and no available strategies have been developed to solve these problems.
Mei Peng, Mei Peng, Jun Deng, Sichun Zhou, Di Xiao, Jiahui Long, Nan Zhang, Caimei He, Miao Mo, Xiaoping Yang   +9 more
doaj   +1 more source

Complex I inhibition by phenformin.

, 2014
(A) CT26 cells were treated with or without phenformin for 24 hours and then extracts were prepared to measure complex I activity as described in Materials and Methods.
Yuh-Seog Jung (511907), Joon Young Choi (511908), W. Keith Miskimins (511903), Hyun Joo Ahn (511904), Ji Yeon Kim (511905), Sun Ryu (511906)   +5 more
core   +1 more source