Results 31 to 40 of about 6,979 (257)
Phosphorylation by Akt within the ST loop of AMPK-α1 down-regulates its activation in tumour cells [PDF]
, 2014 The insulin/IGF-1 (insulin-like growth factor 1)-activated protein kinase Akt (also known as protein kinase B) phosphorylates Ser(487) in the ‘ST loop’ (serine/threonine-rich loop) within the C-terminal domain of AMPK-α1 (AMP-activated protein kinase-α1),
Chen +53 more
core +4 more sources
Phenformin alone or combined with gefitinib inhibits bladder cancer via AMPK and EGFR pathways
Cancer Communications, 2018 Background In previous studies, we have shown that the combination of metformin and gefitinib inhibits the growth of bladder cancer cells. Here we examined whether the metformin analogue phenformin, either used alone or in combination with gefitinib ...
Yanjun Huang +8 more
doaj +1 more source
Guanidine‐Based Ligands in Bioinorganic Chemistry: Coordination Modes and Applications in Anticancer Metallodrugs [PDF]
Bioinorg Chem ApplGuanidine‐containing molecules represent a versatile class of nitrogen‐rich compounds whose unique structural and physicochemical features underpin a rich and tunable coordination chemistry. Their capacity to act as strong donor ligands, stabilize a variety of metal centers in different oxidation states, and access multiple coordination modes has ...
del Campo-Balguerías A +3 more
europepmc +2 more sources
Resistance to BRAF inhibitors induces glutamine dependency in melanoma cells [PDF]
, 2015 BRAF inhibitors can extend progression-free and overall survival in melanoma patients whose tumors harbor mutations in BRAF. However, the majority of patients eventually develop resistance to these drugs. Here we show that BRAF mutant melanoma cells that
Baenke, Franziska +12 more
core +1 more source
Frontiers in Pharmacology, 2018 Background and Purpose: The anti-diabetic biguanide drugs metformin and phenformin exhibit antitumor activity in various models. However, their radiomodulatory effect under hypoxic conditions, particularly for phenformin, is largely unknown.
Sven de Mey +11 more
doaj +1 more source
A Comparative Study of the Lipophilicity of Metformin and Phenformin
Molecules, 2021 The results presented in this paper confirm the beneficial role of an easy-to-use and low-cost thin-layer chromatography (TLC) technique for describing the retention behavior and the experimental lipophilicity parameter of two biguanide derivatives ...
Małgorzata Dołowy +2 more
doaj +1 more source
Serine one-carbon catabolism with formate overflow [PDF]
, 2016 Serine catabolism to glycine and a one-carbon unit has been linked to the anabolic requirements of proliferating mammalian cells. However, genome-scale modeling predicts a catabolic role with one-carbon release as formate. We experimentally prove that in
Athineos, Dimitris +11 more
core +1 more source
Artificial Cells, Nanomedicine, and Biotechnology, 2019 Radiotherapy (RT) is a common treatment for head and neck cancers, but central nervous system function can be impaired by clinical radiation doses. This experimental study evaluated the protective efficacy of the anti-hyperglycaemic/anti-neoplastic agent
Lu Gan +9 more
doaj +1 more source
Biological Properties of Transition Metal Complexes with Metformin and Its Analogues
Pharmaceuticals, 2022 Metformin is a widely prescribed medication for the treatment and management of type 2 diabetes. It belongs to a class of biguanides, which are characterized by a wide range of diverse biological properties, including anticancer, antimicrobial ...
Daniil A. Rusanov +2 more
doaj +1 more source
Improved pH-Responsive Release of Phenformin from Low-Defect Graphene Compared to Graphene Oxide
ACS Omega, 2021 Abdelnour Alhourani +4 more
doaj +2 more sources