Results 21 to 30 of about 6,979 (257)
International Journal of Electrochemical Science, 2021 Layered double hydroxides (LDHs) are a kind of lamellar materials, which have been widely developed in electrochemical sensor owing to theirexcellent properties, such as large specific surface area, unique ion-exchange characteristic and good ...
Jing Li +6 more
doaj +1 more source
Mechanism of Activation of AMPK by Cordycepin [PDF]
, 2020 Cordycepin (3′-deoxyadenosine) is a major bioactive agent in Cordyceps militaris, a fungus used in traditional Chinese medicine. It has been proposed to have many beneficial metabolic effects by activating AMP-activated protein kinase (AMPK), but the ...
Atrih, Abdelmadjid +5 more
core +2 more sources
Prostate International, 2023 Background: Metformin and phenformin, biguanide derivatives that are widely used to treat type 2 diabetes mellitus, have recently been shown to exert potential anticancer effects in prostate cancer.
Yunlim Kim +7 more
doaj +1 more source
Metformin induces distinct bioenergetic and metabolic profiles in sensitive versus resistant high grade serous ovarian cancer and normal fallopian tube secretory epithelial cells. [PDF]
, 2017 Metformin is a widely used agent for the treatment of diabetes and infertility, however, it has been found to have anti-cancer effects in a variety of malignancies including high grade serous ovarian cancer (HGSC).
Aspuria, Paul-Joseph P +6 more
core +1 more source
A novel, de novo mutation in PRKAG2 gene:infantile-onset phenotype and signaling pathway involved [PDF]
, 2017 PRKAG2 encodes the γ2-subunit isoform of the 5' AMP-activated protein kinase (AMPK), a heterotrimeric enzyme with major roles in regulation of energy metabolism in response to cellular stress.
Xu, Yanchun +7 more
core +2 more sources
Progress in antitumor mechanisms and applications of phenformin (Review). [PDF]
Oncol RepZhong Q, Li D, Yang XP.
europepmc +3 more sources
Calcium signalling links MYC to NUAK1 [PDF]
, 2018 NUAK1 is a member of the AMPK-related family of kinases. Recent evidence suggests that NUAK1 is an important regulator of cell adhesion and migration, cellular and organismal metabolism, and regulation of TAU stability.
Hedley, A, +5 more
core +1 more source
Molecules, 2021 Resident cancer cells with stem cell-like features induce drug tolerance, facilitating survival of glioblastoma (GBM). We previously showed that strategies targeting tumor bioenergetics present a novel emerging avenue for treatment of GBM.
Hun Ho Park +8 more
doaj +1 more source
Insulin-stimulated phosphorylation of endothelial nitric oxide synthase at serine-615 contributes to nitric oxide synthesis [PDF]
, 2009 Insulin stimulates endothelial NO (nitric oxide) synthesis via PKB (protein kinase B)/Akt-mediated phosphorylation and activation of eNOS (endothelial NO synthase) at Ser-1177.
Alasdair R. Boyd +32 more
core +5 more sources
Mechanisms of Paradoxical Activation of AMPK by the Kinase Inhibitors SU6656 and Sorafenib [PDF]
, 2017 SU6656, a Src kinase inhibitor, was reported to increase fat oxidation and reduce body weight in mice, with proposed mechanisms involving AMPK activation via inhibition of phosphorylation of either LKB1 or AMPK by the Src kinase, Fyn.
Auciello +52 more
core +4 more sources