Results 21 to 30 of about 856 (149)

Phenformin and ataxia‐telangiectasia mutated inhibitors synergistically co‐suppress liver cancer cell growth by damaging mitochondria

FEBS Open Bio, 2021
Inhibitors of ataxia–telangiectasia mutated (ATM), such as KU‐55933 (Ku), represent a promising class of novel anticancer drugs. In addition, the biguanide derivative phenformin exhibits antitumor activity superior to that of the AMPK activator metformin.
Tianyu Wu, Sichun Zhou, Mei Qin, Jing Tang, Xinjian Yan, Lingli Huang, Meiyuan Huang, Jun Deng, Di Xiao, Xin Hu, Jingtao Wu, Xiaoping Yang, Gaofeng Li   +12 more
doaj   +1 more source

A Novel Electrochemical Biosensor based on Layered Hydroxide Nanosheets/DNA Composite for the Determination of Phenformin Hydrochloride

International Journal of Electrochemical Science, 2021
Layered double hydroxides (LDHs) are a kind of lamellar materials, which have been widely developed in electrochemical sensor owing to theirexcellent properties, such as large specific surface area, unique ion-exchange characteristic and good ...
Jing Li, Jie Bai, Li Dong, Miao Yang, Yaping Hu, Li Gao, Huiqin Qian   +6 more
doaj   +1 more source

A novel biguanide derivative, IM176, induces prostate cancer cell death by modulating the AMPK-mTOR and androgen receptor signaling pathways

Prostate International, 2023
Background: Metformin and phenformin, biguanide derivatives that are widely used to treat type 2 diabetes mellitus, have recently been shown to exert potential anticancer effects in prostate cancer.
Yunlim Kim, Sangjun Yoo, Bumjin Lim, Jun Hyuk Hong, Cheol Kwak, Dalsan You, Jung Jin Hwang, Choung-Soo Kim   +7 more
doaj   +1 more source

AMPK Signaling Involvement for the Repression of the IL-1β-Induced Group IIA Secretory Phospholipase A2 Expression in VSMCs. [PDF]

PLoS ONE, 2015
Secretory Phospholipase A2 of type IIA (sPLA2 IIA) plays a crucial role in the production of lipid mediators by amplifying the neointimal inflammatory context of the vascular smooth muscle cells (VSMCs), especially during atherogenesis.
Khadija El Hadri, Chantal Denoyelle, Lucas Ravaux, Benoit Viollet, Marc Foretz, Bertrand Friguet, Mustapha Rouis, Michel Raymondjean   +7 more
doaj   +1 more source

Combinatorial Therapeutic Effect of Inhibitors of Aldehyde Dehydrogenase and Mitochondrial Complex I, and the Chemotherapeutic Drug, Temozolomide against Glioblastoma Tumorspheres

Molecules, 2021
Resident cancer cells with stem cell-like features induce drug tolerance, facilitating survival of glioblastoma (GBM). We previously showed that strategies targeting tumor bioenergetics present a novel emerging avenue for treatment of GBM.
Hun Ho Park, Junseong Park, Hye Joung Cho, Jin-Kyoung Shim, Ju Hyung Moon, Eui Hyun Kim, Jong Hee Chang, Soo Youl Kim, Seok-Gu Kang   +8 more
doaj   +1 more source

Antidiabetic Biguanides Radiosensitize Hypoxic Colorectal Cancer Cells Through a Decrease in Oxygen Consumption

Frontiers in Pharmacology, 2018
Background and Purpose: The anti-diabetic biguanide drugs metformin and phenformin exhibit antitumor activity in various models. However, their radiomodulatory effect under hypoxic conditions, particularly for phenformin, is largely unknown.
Sven de Mey, Heng Jiang, Cyril Corbet, Hui Wang, Inès Dufait, Inès Dufait, Kalun Law, Estelle Bastien, Valeri Verovski, Thierry Gevaert, Olivier Feron, Mark De Ridder   +11 more
doaj   +1 more source

Phenformin, But Not Metformin, Delays Development of T Cell Acute Lymphoblastic Leukemia/Lymphoma via Cell-Autonomous AMPK Activation

Cell Reports, 2019
Summary: AMPK acts downstream of the tumor suppressor LKB1, yet its role in cancer has been controversial. AMPK is activated by biguanides, such as metformin and phenformin, and metformin use in diabetics has been associated with reduced cancer risk ...
Diana Vara-Ciruelos, Madhumita Dandapani, Fiona M. Russell, Katarzyna M. Grzes, Abdelmadjid Atrih, Marc Foretz, Benoit Viollet, Douglas J. Lamont, Doreen A. Cantrell, D. Grahame Hardie   +9 more
doaj   +1 more source

A Comparative Study of the Lipophilicity of Metformin and Phenformin

Molecules, 2021
The results presented in this paper confirm the beneficial role of an easy-to-use and low-cost thin-layer chromatography (TLC) technique for describing the retention behavior and the experimental lipophilicity parameter of two biguanide derivatives ...
Małgorzata Dołowy, Josef Jampilek, Katarzyna Bober-Majnusz   +2 more
doaj   +1 more source

Biological Properties of Transition Metal Complexes with Metformin and Its Analogues

Pharmaceuticals, 2022
Metformin is a widely prescribed medication for the treatment and management of type 2 diabetes. It belongs to a class of biguanides, which are characterized by a wide range of diverse biological properties, including anticancer, antimicrobial ...
Daniil A. Rusanov, Jiaying Zou, Maria V. Babak   +2 more
doaj   +1 more source

Combination Therapy With CD147‐Targeted Nanoparticles Carrying Phenformin Decreases Lung Cancer Growth

, 2023
Lung cancer is one of the most fatal cancers worldwide. Resistance to conventional therapies remains a hindrance to patient treatment. Therefore, the development of more effective anti-cancer therapeutic strategies is imperative.
Sara Abreu, Abreu, Sara, Baltazar, Fátima, Helena Ferreira, Guedes, Marta, Neves, Nuno M., Nuno M. Neves, Granja, Sara, Sara Granja, Andreia Pereira‐Nunes, Pereira-Nunes, Andreia, Fátima Baltazar, Marta Guedes, Ferreira, Helena   +13 more
core   +2 more sources