Results 11 to 20 of about 6,979 (257)
Synergistic anti-cancer effect of phenformin and oxamate. [PDF]
PLoS ONE, 2014 Phenformin (phenethylbiguanide; an anti-diabetic agent) plus oxamate [lactate dehydrogenase (LDH) inhibitor] was tested as a potential anti-cancer therapeutic combination. In in vitro studies, phenformin was more potent than metformin, another biguanide,
W Keith Miskimins +5 more
doaj +3 more sources
Dual Inhibition of Pirarubicin-Induced AKT and ERK Activations by Phenformin Sensitively Suppresses Bladder Cancer Growth [PDF]
Frontiers in Pharmacology, 2019 Activations of Akt or ERK pathway induced by clinical drugs promote therapeutic failure due to decrease of drug response, and no available strategies have been developed to solve these problems.
Mei Peng +9 more
doaj +2 more sources
Antifibrin action of phenformin [PDF]
Diabetologia, 1975 Effects of phenformin on blood sugar, serum triglyceride, thrombin time, euglobulin clot lysis time and cardiovascular complications were studied in maturity onset diabetes and in atherosclerotic patients with or without diabetes, for a period of 14-18 months.
R N, Banerjee +5 more
openaire +4 more sources
Ligand-Based Pharmacophore Mapping and Virtual Screening for the Search of Biguanide-Like Molecules With Antidiabetic Potentials Targeting Liver Kinase B1. [PDF]
Biochem Res IntType 2 diabetes mellitus (T2DM) is a state where the body’s glucose metabolism is compromised. AMP‐activated protein kinase, or AMPK, has an important part to play in glucose metabolism, and the liver kinase B1 (LKB1) protein functions as a major upstream kinase for AMPK activation, thereby making it appealing therapeutic targets for treating and ...
Reza R +5 more
europepmc +2 more sources
Phenformin Induces Cell Cycle Change, Apoptosis, and Mesenchymal-Epithelial Transition and Regulates the AMPK/mTOR/p70s6k and MAPK/ERK Pathways in Breast Cancer Cells. [PDF]
PLoS ONE, 2015 Breast cancer remains a world-wide challenge, and additional anti-cancer therapies are still urgently needed. Emerging evidence has demonstrated the potent anti-tumor effect of biguanides, among which phenformin was reported to potentially be a more ...
Zhao Liu +5 more
doaj +1 more source
Cell Reports, 2020 Summary: The antidiabetic drug phenformin displays potent anticancer activity in different tumors, but its mechanism of action remains elusive. Using Shh medulloblastoma as model, we show here that at clinically relevant concentrations, phenformin ...
Laura Di Magno +20 more
doaj +1 more source
Pharmaceutics, 2020 Phenformin and metformin are antihyperglycemic drugs that belong to the class of biguanides. Previously, we demonstrated that metformin elicits renoprotective effects in unilateral ureteral obstructed mice by reducing the infiltration of immune cells ...
Mikkel Ø. Nørgård +3 more
doaj +1 more source
Frontiers in Oncology, 2022 Exosomes secreted by cancer cells are important components in the tumor microenvironment, enabling cancer cells to communicate with each other and with noncancerous cells to play important roles in tumor progression and metastasis.
Dexuan Zhuang +15 more
doaj +1 more source
m6A-Mediated Methylation Patterns and Their Association With Obstructive Sleep Apnea in Lung Adenocarcinoma. [PDF]
Cancer Rep (Hoboken)ABSTRACT Background Epigenetic regulation significantly affects immune responses in lung adenocarcinoma (LUAD). However, the role of RNA N6‐methyladenosine (m6A) modification, especially in obstructive sleep apnea‐hypopnea syndrome (OSAHS) within LUAD, is not well understood.
Xia L +6 more
europepmc +2 more sources
FEBS Open Bio, 2021 Inhibitors of ataxia–telangiectasia mutated (ATM), such as KU‐55933 (Ku), represent a promising class of novel anticancer drugs. In addition, the biguanide derivative phenformin exhibits antitumor activity superior to that of the AMPK activator metformin.
Tianyu Wu +12 more
doaj +1 more source