Results 11 to 20 of about 3,344 (169)

Ligand-Based Pharmacophore Mapping and Virtual Screening for the Search of Biguanide-Like Molecules With Antidiabetic Potentials Targeting Liver Kinase B1. [PDF]

Biochem Res Int
Type 2 diabetes mellitus (T2DM) is a state where the body’s glucose metabolism is compromised. AMP‐activated protein kinase, or AMPK, has an important part to play in glucose metabolism, and the liver kinase B1 (LKB1) protein functions as a major upstream kinase for AMPK activation, thereby making it appealing therapeutic targets for treating and ...
Reza R, Samdani MN, Morshed N, Jebin RH, Ahmed I, Reza MS.   +5 more
europepmc   +2 more sources

Unveiling Candidate Markers for Drug Resistance or Synthetic Lethality in Cervical Cancer: Integrative Analysis of Genetic and Pharmacoprofiling. [PDF]

Cancer Rep (Hoboken)
ABSTRACT Introduction Systemic cervical cancer management continues to be challenging. Numerous chemotherapies have been approved, but predicting response is difficult due to the lack of biomarkers. Here, we analyze the genetic and protein profiles of 20 cervical cancer cell lines (CCCLs) and explore their correlation with drug response patterns to ...
Scholl S, Nery ED, Gestraud P, Halladjian M, Girard E, Soria A, Anthony E, De Koning L, Servant N, Berns E, Kamal M.   +10 more
europepmc   +2 more sources

Phenformin Down-Regulates c-Myc Expression to Suppress the Expression of Pro-Inflammatory Cytokines in Keratinocytes

Cells, 2022
The treatment of many skin inflammation diseases, such as psoriasis and atopic dermatitis, is still a challenge and inflammation plays important roles in multiple stages of skin tumor development, including initiation, promotion and metastasis ...
Guanyi Liu, Dingyang Li, Liwei Zhang, Qiuping Xu, Dexuan Zhuang, Panpan Liu, Ling Hu, Huiting Deng, Jianfeng Sun, Shuangshuang Wang, Bin Zheng, Jing Guo, Xunwei Wu   +12 more
doaj   +1 more source

Phenformin Induces Cell Cycle Change, Apoptosis, and Mesenchymal-Epithelial Transition and Regulates the AMPK/mTOR/p70s6k and MAPK/ERK Pathways in Breast Cancer Cells. [PDF]

PLoS ONE, 2015
Breast cancer remains a world-wide challenge, and additional anti-cancer therapies are still urgently needed. Emerging evidence has demonstrated the potent anti-tumor effect of biguanides, among which phenformin was reported to potentially be a more ...
Zhao Liu, Lidong Ren, Chenghao Liu, Tiansong Xia, Xiaoming Zha, Shui Wang   +5 more
doaj   +1 more source

Synergistic anti-cancer effect of phenformin and oxamate. [PDF]

PLoS ONE, 2014
Phenformin (phenethylbiguanide; an anti-diabetic agent) plus oxamate [lactate dehydrogenase (LDH) inhibitor] was tested as a potential anti-cancer therapeutic combination. In in vitro studies, phenformin was more potent than metformin, another biguanide,
W Keith Miskimins, Hyun Joo Ahn, Ji Yeon Kim, Sun Ryu, Yuh-Seog Jung, Joon Young Choi   +5 more
doaj   +1 more source

Phenformin Attenuates Renal Injury in Unilateral Ureteral Obstructed Mice without Affecting Immune Cell Infiltration

Pharmaceutics, 2020
Phenformin and metformin are antihyperglycemic drugs that belong to the class of biguanides. Previously, we demonstrated that metformin elicits renoprotective effects in unilateral ureteral obstructed mice by reducing the infiltration of immune cells ...
Mikkel Ø. Nørgård, Michael Christensen, Henricus A.M. Mutsaers, Rikke Nørregaard   +3 more
doaj   +1 more source

Phenformin suppresses angiogenesis through the regulation of exosomal microRNA-1246 and microRNA-205 levels derived from oral squamous cell carcinoma cells

Frontiers in Oncology, 2022
Exosomes secreted by cancer cells are important components in the tumor microenvironment, enabling cancer cells to communicate with each other and with noncancerous cells to play important roles in tumor progression and metastasis.
Dexuan Zhuang, Shuangshuang Wang, Guanyi Liu, Guanyi Liu, Panpan Liu, Panpan Liu, Huiting Deng, Jianfeng Sun, Chang Liu, Xue Leng, Qun Zhang, Fuxiang Bai, Jun Mi, Xunwei Wu, Xunwei Wu, Xunwei Wu   +15 more
doaj   +1 more source

Phenformin and ataxia‐telangiectasia mutated inhibitors synergistically co‐suppress liver cancer cell growth by damaging mitochondria

FEBS Open Bio, 2021
Inhibitors of ataxia–telangiectasia mutated (ATM), such as KU‐55933 (Ku), represent a promising class of novel anticancer drugs. In addition, the biguanide derivative phenformin exhibits antitumor activity superior to that of the AMPK activator metformin.
Tianyu Wu, Sichun Zhou, Mei Qin, Jing Tang, Xinjian Yan, Lingli Huang, Meiyuan Huang, Jun Deng, Di Xiao, Xin Hu, Jingtao Wu, Xiaoping Yang, Gaofeng Li   +12 more
doaj   +1 more source

A Novel Electrochemical Biosensor based on Layered Hydroxide Nanosheets/DNA Composite for the Determination of Phenformin Hydrochloride

International Journal of Electrochemical Science, 2021
Layered double hydroxides (LDHs) are a kind of lamellar materials, which have been widely developed in electrochemical sensor owing to theirexcellent properties, such as large specific surface area, unique ion-exchange characteristic and good ...
Jing Li, Jie Bai, Li Dong, Miao Yang, Yaping Hu, Li Gao, Huiqin Qian   +6 more
doaj   +1 more source

Single-Cell Transcriptomic Analysis of Chemotherapy-Induced Changes in Osteosarcoma With a Pyroptosis-Related Gene-Based Prognostic Model. [PDF]

J Cell Mol Med
ABSTRACT Osteosarcoma, the most common primary malignant bone tumour, presents significant treatment challenges due to its complex tumour microenvironment and the development of chemoresistance. This study employs single‐cell transcriptomics to investigate chemotherapy‐induced changes in osteosarcoma at both the cellular and molecular levels.
Jin T, Dong L, Kai W, Yu Z, Yu G, Liu W.
europepmc   +2 more sources