Results 11 to 20 of about 856 (149)
Synergistic anti-cancer effect of phenformin and oxamate. [PDF]
PLoS ONE, 2014 Phenformin (phenethylbiguanide; an anti-diabetic agent) plus oxamate [lactate dehydrogenase (LDH) inhibitor] was tested as a potential anti-cancer therapeutic combination. In in vitro studies, phenformin was more potent than metformin, another biguanide,
W Keith Miskimins +5 more
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Pharmaceutics, 2020 Phenformin and metformin are antihyperglycemic drugs that belong to the class of biguanides. Previously, we demonstrated that metformin elicits renoprotective effects in unilateral ureteral obstructed mice by reducing the infiltration of immune cells ...
Mikkel Ø. Nørgård +3 more
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Cells, 2022 The treatment of many skin inflammation diseases, such as psoriasis and atopic dermatitis, is still a challenge and inflammation plays important roles in multiple stages of skin tumor development, including initiation, promotion and metastasis ...
Guanyi Liu +12 more
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Phenformin alone or combined with gefitinib inhibits bladder cancer via AMPK and EGFR pathways
Cancer Communications, 2018 Background In previous studies, we have shown that the combination of metformin and gefitinib inhibits the growth of bladder cancer cells. Here we examined whether the metformin analogue phenformin, either used alone or in combination with gefitinib ...
Yanjun Huang +8 more
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Phenformin Inhibits Hedgehog-Dependent Tumor Growth through a Complex I-Independent Redox/Corepressor Module [PDF]
Cell Reports, 2020 Summary: The antidiabetic drug phenformin displays potent anticancer activity in different tumors, but its mechanism of action remains elusive. Using Shh medulloblastoma as model, we show here that at clinically relevant concentrations, phenformin ...
Laura Di Magno +20 more
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Artificial Cells, Nanomedicine, and Biotechnology, 2019 Radiotherapy (RT) is a common treatment for head and neck cancers, but central nervous system function can be impaired by clinical radiation doses. This experimental study evaluated the protective efficacy of the anti-hyperglycaemic/anti-neoplastic agent
Lu Gan +9 more
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Improved pH-Controlled Release of Phenformin from Low-Defect Graphene Compared to Graphene Oxide [PDF]
, 2021 Graphene-based drug carriers provide a promising addition to current cancer drug 8 delivery options. Increased accessibility of high-quality graphene made by plasma- enhanced chemical vapor deposition (PE-CVD) makes it an attractive material to re-visit ...
Lutz, Eichacker +4 more
core +1 more source
Phenformin Induces Cell Cycle Change, Apoptosis, and Mesenchymal-Epithelial Transition and Regulates the AMPK/mTOR/p70s6k and MAPK/ERK Pathways in Breast Cancer Cells. [PDF]
PLoS ONE, 2015 Breast cancer remains a world-wide challenge, and additional anti-cancer therapies are still urgently needed. Emerging evidence has demonstrated the potent anti-tumor effect of biguanides, among which phenformin was reported to potentially be a more ...
Zhao Liu +5 more
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Frontiers in Oncology, 2022 Exosomes secreted by cancer cells are important components in the tumor microenvironment, enabling cancer cells to communicate with each other and with noncancerous cells to play important roles in tumor progression and metastasis.
Dexuan Zhuang +15 more
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Repurposing Metabolic Inhibitors in the Treatment of Colon Adenocarcinoma Patient-Derived Models
Cells, 2023 The effect of agonists on AMP-activated protein kinase (AMPK), mainly metformin and phenformin, has been appreciated in the treatment of multiple types of tumors.
Bora Lee +5 more
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