Results 71 to 80 of about 856 (149)

Studies on the metabolism and toxity of phenformin. [PDF]

, 2018
Phenformin (N[1]-phenethylbiguanide) is an oral hypoglycaemic agent which has been in use in the U. K. since 1959 for the treatment of some forms of diabetes.
Guest, Derek.
core  

Identification of PD‐1‐Related Genes as Prognostic Biomarkers in Lung Adenocarcinoma

Human Mutation, Volume 2026, Issue 1, 2026.
Background The PD‐1/PD‐L1 axis plays a critical role in suppressing T‐cell activation and facilitating immune evasion in lung adenocarcinoma (LUAD). This study focused on PD‐1‐related genes to develop a robust prognostic prediction model for LUAD. Methods Immune scores were calculated using the ESTIMATE algorithm, and immune‐related gene modules were ...
Bin Jia, Ting Gong, Chen Chen, Bingsheng Sun, Zhenfa Zhang, Suraiya Saleem   +5 more
wiley   +1 more source

Bone morphogenetic protein inhibitors and mitochondria targeting agents synergistically induce apoptosis-inducing factor (AIF) caspase-independent cell death in lung cancer cells

Cell Communication and Signaling, 2022
Background Bone morphogenetic proteins (BMP) are evolutionarily conserved morphogens that are reactivated in lung carcinomas. In lung cancer cells, BMP signaling suppresses AMP activated kinase (AMPK) by inhibiting LKB1.
Arindam Mondal, Jacques Roberge, John Gilleran, Youyi Peng, Dongxuan Jia, Moumen Akel, Yash Patel, Harrison Zoltowski, Anupama Doraiswamy, John Langenfeld   +9 more
doaj   +1 more source

Muscle Organoids Reveal Exercise‐Like Contractions Rapidly Promote Muscle Health Via Lamtor1's Signaling to Both AMPK and mTOR

Advanced Science, Volume 12, Issue 48, December 29, 2025.
This study develops a novel 3D human skeletal muscle organoid platform to study the immediate molecular effects of exercise‐like contractions. The model uncovers rapid proteomic and transcriptomic responses, resolving a fundamental paradox by demonstrating how exercise‐induced Lamtor1 coordinately activates both AMPK and mTORC1. Lamtor1 is a compelling
Ziyue Yao, Zongmin Jiang, Xupeng Liu, Liping Zhang, Siyu Guo, Yu Chen, Lanfang Luo, Shilin Ma, Peng Wang, Ng Shyh‐Chang   +9 more
wiley   +1 more source

Treatment of pancreatic cancer patient–derived xenograft panel with metabolic inhibitors reveals efficacy of phenformin

, 2017
Purpose: To identify effective metabolic inhibitors to suppress the aggressive growth of pancreatic ductal adenocarcinoma (PDAC), we explored the in vivo antitumor efficacy of metabolic inhibitors, as single agents, in a panel of patient-derived PDAC ...
Elizabeth De Oliveira, Chi V. Dang, Rabinowitz, Joshua D., Al-Shahrour, Fátima, Joshua D. Rabinowitz, Yabuuchi, Shinichi, Shweta G. Pai, Hidalgo, Manuel, Anirban Maitra, Héctor Tejero, Manuel Hidalgo, Tejero, Héctor, N.V. Rajeshkumar, Pai, Shweta G., Rajeshkumar, N.V., De Oliveira, Elizabeth, Kamphorst, Jurre J., Dang, Chi V., Jurre J. Kamphorst, Maitra, Anirban, Shinichi Yabuuchi, Fátima Al-Shahrour   +21 more
core   +1 more source

Predicting OCT2/MATEs‐Mediated Drug Interactions in Healthy Volunteers and Patients with Chronic Kidney Disease: Insights from Extended Clearance Concept, Endogenous Biomarkers, and In Vitro Inhibition Studies (Perspectives from the International Transporter Consortium)

Clinical Pharmacology &Therapeutics, Volume 118, Issue 5, Page 994-1014, November 2025.
Organic cation transporter (OCT) 2 and multidrug and toxin extrusion (MATE) transporters play significant roles in the renal secretion of organic cations and drug–drug interactions (DDIs). Recent in vitro studies indicate that the Ki values for OCT2 exhibit substrate dependency and increase in potency with pre‐incubation.
Satoshi Asano, Aleksandra Galetin, Yoshiko Tomita, Kathleen M. Giacomini, Xiaoyan Chu, Xinning Yang, Toshimichi Nakamura, Hiroyuki Kusuhara, Yuichi Sugiyama   +8 more
wiley   +1 more source

Brain-Targeted Delivery of Phenformin Using Phospholipid and Non-Phospholipid Vesicles for SHH Medulloblastoma

Nanomaterials
Medulloblastoma (MB) is the most frequent brain malignancy in children, frequently driven by deregulated Sonic Hedgehog (SHH) signaling. We previously identified the antidiabetic drug phenformin (Phen) as a potent Gli1 inhibitor that suppresses SHH ...
Laura Di Magno, Federica Rinaldi, Luca Campea, Giorgia Della Rocca, Jacopo Forte, Eleonora D’Intino, Sara Cairoli, Bianca Maria Goffredo, Maria Carafa, Elena Del Favero, Carlotta Marianecci, Gianluca Canettieri   +11 more
doaj   +1 more source

Integrating Metabolic Modulation and Nanomedicine for Cancer Immunotherapy

Advanced Science, Volume 12, Issue 40, October 27, 2025.
Metabolic rewiring in cancer is mapped across glucose, amino acid, lipid, nucleotide, and mitochondrial pathways, with emphasis on immune regulation. The review integrates mechanisms linking these pathways to tumor progression and therapy resistance, and profiles nanomaterial platforms that both deliver therapeutics and actively reprogram ...
Xiaosu Zhou, Ruibing Deng, Zunde Liao, Xiaoyu Huang, Junting Huang, Hanlou Yang, Kam W. Leong, Yiling Zhong   +7 more
wiley   +1 more source

The Pituitary Gland is a Novel Major Site of Action of Metformin in Non-Human Primates: a Potential Path to Expand and Integrate Its Metabolic Actions

Cellular Physiology and Biochemistry, 2018
Background/Aims: Biguanides are anti-hyperglycaemic agents used to treat diabetes by acting primarily on the liver, inhibiting hepatic gluconeogenesis. However, biguanides may target other key metabolic tissues to exert beneficial actions. As the “master
Mari C. Vázquez-Borrego, Antonio C. Fuentes-Fayos, Manuel D. Gahete, Justo P. Castaño, Rhonda D. Kineman, Raúl M. Luque   +5 more
doaj   +1 more source

Repurposing the Antidepressant Sertraline: A Systematic Scoping Review of Its Anticancer Mechanisms

Pharmacology Research &Perspectives, Volume 13, Issue 5, October 2025.
A multi‐targeted antidepressant with strong preclinical anticancer activity, sertraline represents a candidate for therapeutic repurposing. ABSTRACT Drug repurposing offers a cost‐effective and time‐efficient strategy for identifying new cancer therapies. Sertraline, a widely prescribed selective serotonin reuptake inhibitor (SSRI), has shown promising
Ciara B. Blum, McCarlie‐Jayne Dohrmann, Lucia McCarthy, Milli McMenamin, Liam A. O'Callaghan   +4 more
wiley   +1 more source