Results 71 to 80 of about 6,979 (257)

The mechanisms of action of metformin [PDF]

, 2017
Metformin is a widely-used drug that results in clear benefits in relation to glucose metabolism and diabetes-related complications. The mechanisms underlying these benefits are complex and still not fully understood.
A Martin-Montalvo, A Natali, AK Madiraju, AR Cameron, CA Bannister, CJ Bailey, CJ Bailey, CS Zhang, D Kirpichnikov, D Preiss, D. Grahame Hardie, DG Hardie, DS Wang, Ewan R. Pearson, F Cabreiro, FA Duca, FA Ross, G Schafer, G Zhou, GG Graham, Graham Rena, H Muller, HCS Howlett, HCS Howlett, HJ Pryor, HR Bridges, JA Baur, JB Buse, JJ Howell, JM Corton, K Forslund, K Patel, K Zhou, K Zhou, K Zhou, L Logie, L Wu, LC Gormsen, LJ McCreight, LX Cubeddu, M Foretz, M Johanns, M Massollo, MD Fullerton, MF Vincent, MR Owen, MY El-Mir, NR Shin, P Repiscak, PA Lochhead, RA DeFronzo, RA Miller, SA Hawley, SB Vasamsetti, SH Koo, T Dujic, T Dujic, X Quan, Y Shu   +58 more
core   +3 more sources

Muscle Organoids Reveal Exercise‐Like Contractions Rapidly Promote Muscle Health Via Lamtor1's Signaling to Both AMPK and mTOR

Advanced Science, Volume 12, Issue 48, December 29, 2025.
This study develops a novel 3D human skeletal muscle organoid platform to study the immediate molecular effects of exercise‐like contractions. The model uncovers rapid proteomic and transcriptomic responses, resolving a fundamental paradox by demonstrating how exercise‐induced Lamtor1 coordinately activates both AMPK and mTORC1. Lamtor1 is a compelling
Ziyue Yao, Zongmin Jiang, Xupeng Liu, Liping Zhang, Siyu Guo, Yu Chen, Lanfang Luo, Shilin Ma, Peng Wang, Ng Shyh‐Chang   +9 more
wiley   +1 more source

Bone morphogenetic protein inhibitors and mitochondria targeting agents synergistically induce apoptosis-inducing factor (AIF) caspase-independent cell death in lung cancer cells

Cell Communication and Signaling, 2022
Background Bone morphogenetic proteins (BMP) are evolutionarily conserved morphogens that are reactivated in lung carcinomas. In lung cancer cells, BMP signaling suppresses AMP activated kinase (AMPK) by inhibiting LKB1.
Arindam Mondal, Jacques Roberge, John Gilleran, Youyi Peng, Dongxuan Jia, Moumen Akel, Yash Patel, Harrison Zoltowski, Anupama Doraiswamy, John Langenfeld   +9 more
doaj   +1 more source

Resistance to different anthracycline chemotherapeutics elicits distinct and actionable primary metabolic dependencies in breast cancer

eLife, 2021
Chemotherapy resistance is a critical barrier in cancer treatment. Metabolic adaptations have been shown to fuel therapy resistance; however, little is known regarding the generality of these changes and whether specific therapies elicit unique metabolic
Shawn McGuirk, Yannick Audet-Delage, Matthew G Annis, Yibo Xue, Mathieu Vernier, Kaiqiong Zhao, Catherine St-Louis, Lucía Minarrieta, David A Patten, Geneviève Morin, Celia MT Greenwood, Vincent Giguère, Sidong Huang, Peter M Siegel, Julie St-Pierre   +14 more
doaj   +1 more source

Differential regulation by AMP and ADP of AMPK complexes containing different γ subunit isoforms [PDF]

, 2016
The γ subunits of heterotrimeric AMPK complexes contain the binding sites for the regulatory adenine nucleotides AMP, ADP and ATP. We addressed whether complexes containing different γ isoforms display different responses to adenine nucleotides by ...
Ai, Auciello, Bateman, Birk, Calabrese, Chen, Cheung, Corton, D. Grahame Hardie, Dale, Davies, Davies, Fiona A. Ross, Goransson, Gowans, Hardie, Hardie, Hardie, Hardie, Hawley, Hawley, Hawley, Hawley, Hawley, Haystead, Hudson, Hurley, Jaleel, Jensen, Kazgan, Kemp, Koay, Li, Oakhill, Oakhill, Pang, Pinter, Pinter, Polekhina, Polekhina, Salt, Scott, Scott, Shaw, Stapleton, Storer, Thomas E. Jensen, Thornton, Tokumitsu, Turnley, Woods, Woods, Woods, Xiao, Xiao, Xiao, Yu   +56 more
core   +2 more sources

Predicting OCT2/MATEs‐Mediated Drug Interactions in Healthy Volunteers and Patients with Chronic Kidney Disease: Insights from Extended Clearance Concept, Endogenous Biomarkers, and In Vitro Inhibition Studies (Perspectives from the International Transporter Consortium)

Clinical Pharmacology &Therapeutics, Volume 118, Issue 5, Page 994-1014, November 2025.
Organic cation transporter (OCT) 2 and multidrug and toxin extrusion (MATE) transporters play significant roles in the renal secretion of organic cations and drug–drug interactions (DDIs). Recent in vitro studies indicate that the Ki values for OCT2 exhibit substrate dependency and increase in potency with pre‐incubation.
Satoshi Asano, Aleksandra Galetin, Yoshiko Tomita, Kathleen M. Giacomini, Xiaoyan Chu, Xinning Yang, Toshimichi Nakamura, Hiroyuki Kusuhara, Yuichi Sugiyama   +8 more
wiley   +1 more source

Effect of Blood Glucose Concentrations on the Development of Chronic Complications of Diabetes Mellitus [PDF]

, 1998
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/90229/1/j.1875-9114.1998.tb03927.x ...
Montgomery, Patricia A., Swidan, Sahar Z.   +1 more
core   +1 more source

Integrating Metabolic Modulation and Nanomedicine for Cancer Immunotherapy

Advanced Science, Volume 12, Issue 40, October 27, 2025.
Metabolic rewiring in cancer is mapped across glucose, amino acid, lipid, nucleotide, and mitochondrial pathways, with emphasis on immune regulation. The review integrates mechanisms linking these pathways to tumor progression and therapy resistance, and profiles nanomaterial platforms that both deliver therapeutics and actively reprogram ...
Xiaosu Zhou, Ruibing Deng, Zunde Liao, Xiaoyu Huang, Junting Huang, Hanlou Yang, Kam W. Leong, Yiling Zhong   +7 more
wiley   +1 more source

AMP-activated protein kinase:a key regulator of energy balance with many roles in human disease [PDF]

, 2014
The AMP-activated protein kinase (AMPK) is a sensor of cellular energy status that regulates cellular and whole-body energy balance. A recently reported crystal structure has illuminated the complex regulatory mechanisms by which AMP and ADP cause ...
Hardie, D. Grahame
core   +3 more sources

Repurposing the Antidepressant Sertraline: A Systematic Scoping Review of Its Anticancer Mechanisms

Pharmacology Research &Perspectives, Volume 13, Issue 5, October 2025.
A multi‐targeted antidepressant with strong preclinical anticancer activity, sertraline represents a candidate for therapeutic repurposing. ABSTRACT Drug repurposing offers a cost‐effective and time‐efficient strategy for identifying new cancer therapies. Sertraline, a widely prescribed selective serotonin reuptake inhibitor (SSRI), has shown promising
Ciara B. Blum, McCarlie‐Jayne Dohrmann, Lucia McCarthy, Milli McMenamin, Liam A. O'Callaghan   +4 more
wiley   +1 more source