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Endocrinology, Diabetes &Metabolism, Volume 8, Issue 4, July 2025.This updated meta‐analysis evaluates the efficacy and safety of metformin as add‐on therapy to insulin in patients with type 1 diabetes. The results show reductions in HbA1c, BMI, and insulin dose in both adolescents and adults, alongside improved lipid profiles.
Mohammad Mahdi Masouri +2 more
wiley +1 more source
Metformin selectively targets redox control of complex I energy transduction
Redox Biology, 2018 Many guanide-containing drugs are antihyperglycaemic but most exhibit toxicity, to the extent that only the biguanide metformin has enjoyed sustained clinical use. Here, we have isolated unique mitochondrial redox control properties of metformin that are
Amy R. Cameron +17 more
doaj +1 more source
Diabetes mellitus: Complex interplay between metformin, AKI and lactic acidosis. [PDF]
, 2017 Debate exists regarding the safety of metformin and the risk of metformin-associated lactic acidosis, particularly in the setting of kidney dysfunction.
Kalantar-Zadeh, Kamyar, Rhee, Connie M
core +1 more source
Glutamine Metabolism: Molecular Regulation, Biological Functions, and Diseases
MedComm, Volume 6, Issue 7, July 2025.Tumor cells adapt to nutrient‐poor environments by altering metabolism to acquire essential nutrients. They convert glutamine into glutamate and α‐ketoglutarate, supporting mTOR activation and sugar biosynthesis. Disruption of mTORC1 signaling is linked to disease, while glutamine and leucine activation promotes cell growth and inhibits autophagy ...
Mudasir A. Kumar +10 more
wiley +1 more source
PLoS ONE, 2014 AimsPhenformin, resveratrol and AICAR stimulate the energy sensor 5'-AMP activated kinase (AMPK) and inhibit the first step of ribosome biogenesis, de novo RNA synthesis in nucleoli.
Mohamed Kodiha +3 more
doaj +1 more source
The Na+/Glucose Cotransporter Inhibitor Canagliflozin Activates AMPK by Inhibiting Mitochondrial Function and Increasing Cellular AMP Levels [PDF]
, 2016 Canagliflozin, dapagliflozin and empagliflozin, all recently approved for treatment of Type 2 diabetes, were derived from the natural product phlorizin.
Brennan K. Smith +12 more
core +5 more sources
Journal of Biology, 2003 Background The AMP-activated protein kinase (AMPK) cascade is a sensor of cellular energy charge that acts as a 'metabolic master switch' and inhibits cell proliferation. Activation requires phosphorylation of Thr172 of AMPK within the activation loop by
Alessi Dario R +7 more
doaj +1 more source
Oral Hypoglycemic Agents [PDF]
, 1977 In conclusion, comment is made on the findings of the University Group Diabetes Program (UGDP). The purpose of the UGDP was to determine whether or not control of blood glucose levels would help to prevent or delay vascular disease in non-insulin ...
Rifkin, Harold
core +1 more source
A new perspective on metformin therapy in type 1 diabetes [PDF]
, 2017 Metformin is quite frequently used off-label in type 1 diabetes to limit insulin dose requirement. Guidelines recommend that it can improve glucose control in those who are overweight and obese but evidence in support of this is limited.
Boyle, James G. +2 more
core +1 more source
How do changes in the mtDNA and mitochondrial dysfunction influence cancer and cancer therapy? Challenges, opportunities and models [PDF]
, 2015 Several mutations in nuclear genes encoding for mitochondrial components have been associated with an increased cancer risk or are even causative, e.g. succinate dehydrogenase (SDHB, SDHC and SDHD genes) and iso-citrate dehydrogenase (IDH1 and IDH2 genes)
Boutros, P.C. (Paul C.) +9 more
core +1 more source