Results 91 to 100 of about 856 (149)
Hypoglycaemic effect of combination of glibenclamide and phenformin - an experimental study
, 1978 Clinical studies have shown that a combination of glybenclamide and phenformin is more useful in control of diabetes than either drug used alone. This pharmacological study shows that phenformin had no significant hypoglycaemic effect in normal dogs ...
Mohan, V. +3 more
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Phenformin inhibits tumor growth through a Complex I-independent redox/corepressor axis [PDF]
, 2019 The antidiabetic drug phenformin displays potent anticancer activity in different tumors but its mechanism of action remains elusive. Using Shh Medulloblastoma as model, we show here that at the clinically relevant concentrations phenformin elicits a ...
Manni, Simona
core
Repurposing phenformin for the targeting of glioma stem cells and the treatment of glioblastoma
, 2016 Glioblastoma (GBM) is the most aggressive primary brain tumor with poor prognosis. Here, we studied the effects of phenformin, a mitochondrial complex I inhibitor and more potent chemical analog of the diabetes drug metformin on the inhibition of cell ...
Cazacu, Simona +8 more
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Studies on the metabolism and toxity of phenformin.
, 1978 Phenformin (N[1]-phenethylbiguanide) is an oral hypoglycaemic agent which has been in use in the U. K. since 1959 for the treatment of some forms of diabetes.
Guest, Derek.
core
, 2004 Activation of AMP-activated protein kinase (AMPK) by exercise and metformin is beneficial for the treatment of type 2 diabetes. We recently found that, in cultured cells, the LKB1 tumor suppressor protein kinase activates AMPK in response to the ...
Sakamoto, Kei +3 more
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Cytoskeleton Changes Induced in Dupuytren’s Contracture Cells by Phenformin
, 2019 Dupuytren’s contracture is a disease caused by formation of connective tissue in the dermis that will affect the movement of fingers. Myofibroblasts participate in wound healing and excessive scarring in patients with Dupuytren’s contracture and other ...
Ting, Samuel
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Activation of AMPK/mTOR/p70s6k signaling by phenformin.
, 2015 (A) MCF7, ZR-75-1, MDA-MB-231 and SUM1315 cells were treated with or without phenformin for 24 hours. Cell extracts were analyzed by western blotting to detect the expression of p-AMPK, AMPK, p-mTOR, mTOR, p-p70s6k, p70s6k and GAPDH.
Chenghao Liu (761535) +5 more
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Synergism between phenformin and oxamate in mediating cancer cell death.
, 2014 (A) E6E7Ras cells were treated for 2 days with oxamate at the indicated concentrations (0–80 mM) and then dead cells were counted by flow cytometry. (B, C) The indicated cells lines were treated with varying concentrations of phenformin, oxamate, or ...
Yuh-Seog Jung (511907) +5 more
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The anti-cancer effects of phenformin in thyroid cancer cell lines and in normal thyrocytes
, 2019 Phenformin is a biguanide drug which, besides the original anti-diabetic effect, also exerts anti-cancer effects. The aim of this study was to further characterize these latter in terms of both cell-viability and modulation of the secretion of the pro ...
Ngnitejeu, Samuel Tata +7 more
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Phenformin induces epithelial features in breast cancer cells.
, 2015 (A) MCF7, ZR-75-1, MDA-MB-231 and SUM1315 cells were treated with or without phenformin for 24 hours. Cell extracts were analyzed by western blotting to detect the expression of E-cadherin, vimentin and GAPDH. (B) Expression ratios of E-cadherin to GAPDH,
Chenghao Liu (761535) +5 more
core +1 more source