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Toxicological profile of anti-diabetic drugs and emerging measures to reduce the toxic burden. [PDF]
Toxicol RepDugbartey GJ +5 more
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Phenformin-Associated Lactic Acidosis Due to Imported Phenformin
Diabetes Care, 1996OBJECTIVE To emphasize the continued incidence of phenformin-associated lactic acidosis. CASE REPORT We report a case of phenformin-associated lactic acidosis in a Chinese man who received phenformin while in China.
H C, Lu, P P, Parikh, D L, Lorber
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Annals of Internal Medicine, 1973
Excerpt To the editor: The letter by Dr. Wilde (1), which raises the question of a causal association of phenformin and pancreatitis, prompts me to report a case of pancreatitis in association with...
E, Coodley, J, Derasse, J, Carver
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Excerpt To the editor: The letter by Dr. Wilde (1), which raises the question of a causal association of phenformin and pancreatitis, prompts me to report a case of pancreatitis in association with...
E, Coodley, J, Derasse, J, Carver
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Annals of Internal Medicine, 1972
Excerpt To the editor: Phenformin therapy may be associated with a metallic taste, anorexia, nausea, and occasional diarrhea with abdominal cramps.
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Excerpt To the editor: Phenformin therapy may be associated with a metallic taste, anorexia, nausea, and occasional diarrhea with abdominal cramps.
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Pharmacokinetics of Phenformin in Man
The Journal of Clinical Pharmacology, 1975Phenformin was assayed in urine, plasma, and sputum specimens, obtained from two healthy volunteers during the four-day period following oral administration of a single therapeutic dose. Approximately one third of the drug was excreted unchanged in the urine.
D, Alkalay +3 more
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The effect of phenformin on “prediabetes”
Metabolism, 1965Observations are presented on the cortisone glucose tolerance test in 568 relatives of diabetic patients. Twenty-one per cent showed a positive cortisone glucose tolerance curve, including 4.4 per cent who were regarded overtly diabetic from the conventional glucose tolerance curve. A double-blind study was carried out, on the effect of a 6 week course
Douglas L, Wilansky +2 more
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PHENFORMIN AND METABOLIC ACIDOSIS
The Lancet, 1972Abstract A patient with oliguric renal failure complicating accelerated hypertension was given phenformin and ethylœstrenol as fibrinolytic therapy. On the fifth day of this treatment a profound and fatal metabolic acidosis developed despite good control of uraemia by peritoneal dialysis. The acidosis was resistant to 2500 meq.
G A, MacGregor +2 more
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Phenformin and lactic acidosis
Clinical Pharmacology & Therapeutics, 1966There is considerable evidence, both from animal studies and clinical reports, to suggest that the hypoglycemic agent phenformin interferes with lactate metabolism. Experimental data are reported which are consistent with a defiCiency in the ability of phenformin‐treated rats to handle endogenous and exogenous lactate.
J, Lacher, L, Lasagna
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Phenformin-Associated Pancreatitis
Annals of Internal Medicine, 1977Although phenformin has been previously reported to be associated with acute pancreatitis, little emphasis of this association has been made in the literature. We report the case of a 70-year-old diabetic man who developed acute hemorrhagic pancreatitis and severe lactic acidosis while taking phenformin. The patient was not taking any other medications,
H S, Chase, G R, Mogan
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Serum Phenformin Concentrations in Patients with Phenformin-associated Lactic Acidosis
Diabetes, 1977Phenformin concentrations were measured in serum from seven patients with phenformin-associated lactic acidosis, and initial values ranging from 20 to 625 ng./ml. were obtained. Five of the seven patients had serum concentrations within the usual therapeutic range of up to 241 ng./ml. Serum phenformin concentrations were measured serially, and apparent
L A, Conlay +3 more
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