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Attempted Suicide with Phenformin
Diabetes, 1965Following ingestion of .85 gm. of phenformin, in a suicide attempt, the principal symptoms were violent gastrointestinal cramping, nausea, and vomiting, all of a few hours' duration. This appeared to provide major protection against other toxic effects. There was no significant hematemesis or melena.
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Effect of Phenformin in Hyperglycemic Rats
Diabetes, 1974Phenformin administered intraperitoneally in doses of 30 and 100 mg. per kilogram significantly reduced the blood glucose concentration in streptozotocin-diabetic rats, but was virtually inactive in normal healthy rats. Phenformin also antagonized the hyperglycemic effect of an intravenous infusion of epinephrine in normal anesthetized rats and ...
I, Polacek, J, Ouart
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