Results 81 to 90 of about 856 (149)
Phenformin-Induced Mitochondrial Dysfunction Sensitizes Hepatocellular Carcinoma for Dual Inhibition of mTOR [PDF]
, 2018 Purpose: Hepatocellular carcinoma (HCC) ranks second in cancer mortality and has limited therapeutic options. We recently described the synergistic effect of allosteric and ATP-site competitive inhibitors against the mTOR for the treatment of HCC ...
Veiga, Sonia Rosa Pereira da +19 more
core +1 more source
BJUI Compass, Volume 6, Issue 9, September 2025.Abstract Objectives Most, but not all studies, suggest insulin resistance is associated with benign prostatic hyperplasia, but its impact on prostate volume (PV) changes over time remains unclear. We examined whether higher insulin resistance, measured by Homeostatic Model Assessment of Insulin Resistance (HOMA‐IR), is associated with larger PV and ...
James P. Daniels +6 more
wiley +1 more source
Cancer Reports, Volume 8, Issue 9, September 2025.ABSTRACT Background Epigenetic regulation significantly affects immune responses in lung adenocarcinoma (LUAD). However, the role of RNA N6‐methyladenosine (m6A) modification, especially in obstructive sleep apnea‐hypopnea syndrome (OSAHS) within LUAD, is not well understood.
Lei Xia +6 more
wiley +1 more source
AMP‐dependent kinase stimulates the expression of αKlotho
FEBS Open BioRenal αKlotho along with fibroblast growth factor 23 regulates phosphate and vitamin D metabolism. Its cleavage yields soluble Klotho controlling intracellular processes.
Julia Vogt +4 more
doaj +1 more source
Metabolic Rewiring in Response to Biguanides Is Mediated by mROS/HIF-1a in Malignant Lymphocytes
Cell Reports, 2019 Summary: Metabolic flexibility allows cells to adapt to various environments and limits the efficacy of metabolic drugs. Therapeutic targeting of cancer metabolism relies on defining limiting requirements and vulnerabilities in the highly dynamic ...
Hamidullah Khan +7 more
doaj +1 more source
Metformin selectively targets redox control of complex I energy transduction
Redox Biology, 2018 Many guanide-containing drugs are antihyperglycaemic but most exhibit toxicity, to the extent that only the biguanide metformin has enjoyed sustained clinical use. Here, we have isolated unique mitochondrial redox control properties of metformin that are
Amy R. Cameron +17 more
doaj +1 more source
Phenformin inhibits the metastasis of MDA-MB-231 cells in nude mice.
, 2015 (A) The luciferase-tagged MDA-MB-231 cells were inoculated intracardially into female nude mice. After the injections, the mice were separated into the control and phenformin groups (10 mice per group).
Chenghao Liu (761535) +5 more
core +1 more source
Some metabolic effects of phenformin and sodium dichloroacetate in rats.
, 1981 An animal model of hyperlactataemia induced by phenformin, an orally-active antidiabetic drug, has been developed using streptozotocin-diabetic rats. A comparison of blood metabolite concentrations of fed, starved and streptozotocin-diabetic rats showed ...
Evans, Peter Francis.
core
Inhibition of Bovine Adenosine Deaminase by Anti-Hyperglycemic Agents Metformin and Phenformin [PDF]
, 2013 Metformin (1,1-dimethylbiguanide) is an anti-hyperglycemic agent that is commonly used in the oral treatment of Type 2 Diabetes Mellitus. Phenformin (phenethylbiguanide) is its structural analog.
Amatya, Neha +3 more
core
Cell death pathways induced by phenformin and oxamate.
, 2014 (A) CT26 cells were treated as indicated at the bottom of each lane. Experiments were performed after either 1 day (left) or 2 days (right) of treatment.
Yuh-Seog Jung (511907) +5 more
core +1 more source