Results 81 to 90 of about 6,979 (257)

Association between insulin resistance and prostate volume: A 4‐year analysis from the Reduction by Dutasteride of Prostate Cancer (REDUCE) Trial

BJUI Compass, Volume 6, Issue 9, September 2025.
Abstract Objectives Most, but not all studies, suggest insulin resistance is associated with benign prostatic hyperplasia, but its impact on prostate volume (PV) changes over time remains unclear. We examined whether higher insulin resistance, measured by Homeostatic Model Assessment of Insulin Resistance (HOMA‐IR), is associated with larger PV and ...
James P. Daniels, Alexander Hernández‐Tirado, James Mirocha, Renning Zheng, Jordan Palmer, Daniel Moreira, Stephen J. Freedland   +6 more
wiley   +1 more source

Treatment of Diabetes With Oral Hypoglycemic Drugs [PDF]

, 1966
Oral hypoglycemic drugs now available are of two types. The biguanides, of which phenformin (DBI) is the only one available, increase glucose utilization by muscles.
Moss, James M.
core   +1 more source

Investigation of LKB1 Ser⁴³¹ phosphorylation and Cys⁴³³ farnesylation using mouse knockin analysis reveals an unexpected role of prenylation in regulating AMPK activity [PDF]

, 2014
The LKB1 tumour suppressor protein kinase functions to activate two isoforms of AMPK (AMP-activated protein kinase) and 12 members of the AMPK-related family of protein kinases. The highly conserved C-terminal residues of LKB1 are phosphorylated (Ser(431)
Alessi, Alessi, Alessi, Andrade-Vieira, Baas, Barnes, Bayascas, Boudeau, Boudeau, Boutin, Carling, Carling, Chen, Clark, Collins, Corton, Dario R. Alessi, Davisson, Denison, Denison, Farnsworth, Fogarty, Fogarty, Foretz, Gwinn, Hardie, Hardie, Hawley, Hayashi, Hemminki, Henriksson, Hunter, Jansen, Jeppesen, Ji, Joby Varghese, Kei Sakamoto, Kishi, Koh, Komander, Liu, Lizcano, Maria Stella Ritorto, Martin, McLaughlin, Mitchelhill, Moores, Mora, Najafov, Nakada, Natalia Shpiro, Oakhill, Paul Davies, Robert Gourlay, Sakamoto, Sakamoto, Sakamoto, Sanchez-Cespedes, Sanchez-Cespedes, Sanders, Sapkota, Sapkota, Screaton, Shaw, Shelly, Su, Towler, Vanessa P. Houde, Vavvas, Viollet, Wiggin, Woods, Wullschleger, Zagorska, Zeqiraj, Zeqiraj, Zhang   +76 more
core   +2 more sources

The Pituitary Gland is a Novel Major Site of Action of Metformin in Non-Human Primates: a Potential Path to Expand and Integrate Its Metabolic Actions

Cellular Physiology and Biochemistry, 2018
Background/Aims: Biguanides are anti-hyperglycaemic agents used to treat diabetes by acting primarily on the liver, inhibiting hepatic gluconeogenesis. However, biguanides may target other key metabolic tissues to exert beneficial actions. As the “master
Mari C. Vázquez-Borrego, Antonio C. Fuentes-Fayos, Manuel D. Gahete, Justo P. Castaño, Rhonda D. Kineman, Raúl M. Luque   +5 more
doaj   +1 more source

Metformin treatment for diabetes mellitus correlates with progression and survival in colorectal carcinoma [PDF]

, 2020
BACKGROUND: Diabetes mellitus is unfavorably associated with cancer risk. The purpose of this multi-disciplinary project was to evaluate a possible association of diabetes mellitus and other comorbidities and their treatment with progression of ...
Brown, Robert E., Cempírková, Dana, Dundr, Pavel, Gregorová, Jana, Grimmichová, Tereza, Heneberg, Petr, Janurová, Kateřina, Litschmannová, Martina, Pešta, Michal, Powell, Marta K., Třebický, Ferdinand   +10 more
core   +1 more source

Epithelial–Mesenchymal Transition in Cancer: Insights Into Therapeutic Targets and Clinical Implications

MedComm, Volume 6, Issue 9, September 2025.
This graphical abstract summarizes the effects of ionizing radiation (IR) on epithelial–mesenchymal transition (EMT), emphasizing critical processes such as DNA damage repair, tumor microenvironment interactions, and resistance mechanisms. It highlights EMT‐induced radioresistance regulators, such as TGF‐β, Wnt, Notch, ERK, and various miRNAs, as well ...
Dhasarathdev Srinivasan, Ranjith Balakrishnan, Ankush Chauhan, Jeevan Kumar, Dinesh Murugan Girija, Reena Shrestha, Rupendra Shrestha, Rajasekaran Subbarayan   +7 more
wiley   +1 more source

The Landscape of Cancer Metabolism as a Therapeutic Target

Pathology International, Volume 75, Issue 8, Page 387-402, August 2025.
ABSTRACT Cancer cells reprogram their metabolism during progression to adapt to the tumor microenvironment, which is characterized by distinct differences in nutrient availability, oxygen concentrations, and acidity. This metabolic reprogramming can simultaneously create metabolic vulnerabilities unique to cancer cells, making cancer metabolism a ...
Kenji Ohshima
wiley   +1 more source

Molecular pathways:is AMPK a friend or a foe in cancer? [PDF]

, 2015
The AMP-activated protein kinase (AMPK) is a sensor of cellular energy status expressed in essentially all eukaryotic cells. Once activated by energetic stress via a mechanism that detects increases in AMP:ATP and ADP:ATP ratios, AMPK acts to restore ...
D. Grahame Hardie, Sanchez-Cespedes, Xiao   +2 more
core   +2 more sources

Harnessing Organometallic Au(III) Complexes as Precision Scaffolds for Next‐Generation Therapeutic and Imaging Agents

ChemBioChem, Volume 26, Issue 14, July 18, 2025.
Cyclometalated gold(III) complexes offer a versatile platform for selective biological interactions, including cysteine arylation, redox modulation, and enzyme inhibition. This review explores their roles in anticancer, antimicrobial, and protein modification strategies, highlighting their ability to disrupt metabolic pathways, modulate aquaporins, and
Sophie R. Thomas, Riccardo Bonsignore
wiley   +1 more source

Metabolic Rewiring in Response to Biguanides Is Mediated by mROS/HIF-1a in Malignant Lymphocytes

Cell Reports, 2019
Summary: Metabolic flexibility allows cells to adapt to various environments and limits the efficacy of metabolic drugs. Therapeutic targeting of cancer metabolism relies on defining limiting requirements and vulnerabilities in the highly dynamic ...
Hamidullah Khan, Ashish Anshu, Aman Prasad, Sushmita Roy, Justin Jeffery, Wasakorn Kittipongdaja, David T. Yang, Stefan M. Schieke   +7 more
doaj   +1 more source