Does atorvastatin work more effectively than biguanides in reducing cardiovascular risk factors? [PDF]
Journal of Pharmacy and Bioallied Sciences, 2011 Increased risk of coronary artery disease in diabetic persons is associated with increased level of lipoproteins. Usually, such risks are reverted with glycemic control by antidiabetic medicines in Type I diabetes millitus.
Afshan Siddiq +2 more
doaj +2 more sources
Biguanides enhance antifungal activity against Candida glabrata [PDF]
Virulence, 2018 Candida spp. are the fourth leading cause of nosocomial blood stream infections in North America. Candida glabrata is the second most frequently isolated species, and rapid development of antifungal resistance has made treatment a challenge.
Shuying Xu +13 more
doaj +2 more sources
Biguanides in combination with olaparib limits tumorigenesis of drug‐resistant ovarian cancer cells through inhibition of Snail [PDF]
Cancer Medicine, 2020 Ovarian cancer is the most lethal gynecological malignancy. Currently, new chemotherapeutic strategies are required to improve patient outcome and survival.
Qiong Wang +8 more
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Biguanides antithetically regulate tumor properties by the dose-dependent mitochondrial reprogramming-driven c-Src pathway [PDF]
Cell Reports MedicineSummary: The biguanide metformin attenuates mitochondrial oxidation and is proposed as an anti-cancer therapy. However, recent clinical studies suggest increased proliferation and fatty acid β-oxidation (FAO) in a subgroup of patients with breast cancer (
Jun Hyoung Park +25 more
doaj +3 more sources
Glucose Deprivation Enhances the Antiproliferative Effects of Oral Hypoglycemic Biguanides in Different Molecular Subtypes of Breast Cancer: an in Vitro Study [PDF]
Acta Pharmaceutica, 2018 Extensive in vitro studies have been conducted to evaluate the anticancer activity of oral hypoglycemic agents. Many of these studies experienced detrimental limitations, since they were conducted on cancer cells commonly grown in culture media ...
Bardaweel Sanaa K. +3 more
doaj +5 more sources
Comparing the effects of biguanides and dipeptidyl peptidase-4 inhibitors on cardio-cerebrovascular outcomes, nephropathy, retinopathy, neuropathy, and treatment costs in diabetic patients. [PDF]
PLoS ONEBackgroundWestern guidelines often recommend biguanides as the first-line treatment for diabetes. However, dipeptidyl peptidase-4 (DPP-4) inhibitors, alongside biguanides, are increasingly used as the first-line therapy for type 2 diabetes (T2DM) in ...
Eiji Nakatani +14 more
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Antidiabetic Biguanides as Anti-Aging Drugs [PDF]
, 2020 Evidence has emerged that metformin and other antidiabetic biguabides are promising candidates for pharmacological interventions leading to slowing down of aging, prolonged life span and preventing or postponing age-associate diseases, including cancer ...
Anisimov V.N.
core +3 more sources
Biguanides, anion receptors and sensors [PDF]
, 2017 Biguanides are strong bases (pKa > 10), their protonated forms bind anions and may therefore act as receptors for anions.
Mariia Pushina, Pavel Anzenbacher
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Towards Elucidating the Mechanism of Action of Biguanides [PDF]
, 2018 Diabetes type 2 patients are insensitive to insulin, a condition that leads to reduced glucose uptake by cells and, subsequently, to high concentration of glucose in the blood.
Goeldel, Nicolas Peter
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Activity of Certain Aryl-Substituted Biguanides as Accelerators of Vulcanization [PDF]
, 1928 Aryl-substituted biguanides are rubber vulcanization accelerators of moderate activity. The relation between the chemical constitution of the substituted radicals and the activity of the biguanides is, in general, about the same as found by other ...
G. B. L. Smith, A. J. Weiss
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