Results 11 to 20 of about 14,382 (155)

Environment Dictates Dependence on Mitochondrial Complex I for NAD+ and Aspartate Production and Determines Cancer Cell Sensitivity to Metformin [PDF]

, 2018
Metformin use is associated with reduced cancer mortality, but how metformin impacts cancer outcomes is controversial. Although metformin can act on cells autonomously to inhibit tumor growth, the doses of metformin that inhibit proliferation in tissue ...
Bush, Lauren N., Davidson, Shawn M, Freinkman, Elizaveta, Gitego, Nadege, Gui, Dan Yi, Hosios, Aaron Marc, Luengo, Alba, Sullivan, Lucas Bryan, Thomas, Craig J., Vander Heiden, Matthew G.   +9 more
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The mechanisms of action of metformin [PDF]

, 2017
Metformin is a widely-used drug that results in clear benefits in relation to glucose metabolism and diabetes-related complications. The mechanisms underlying these benefits are complex and still not fully understood.
A Martin-Montalvo, A Natali, AK Madiraju, AR Cameron, CA Bannister, CJ Bailey, CJ Bailey, CS Zhang, D Kirpichnikov, D Preiss, D. Grahame Hardie, DG Hardie, DS Wang, Ewan R. Pearson, F Cabreiro, FA Duca, FA Ross, G Schafer, G Zhou, GG Graham, Graham Rena, H Muller, HCS Howlett, HCS Howlett, HJ Pryor, HR Bridges, JA Baur, JB Buse, JJ Howell, JM Corton, K Forslund, K Patel, K Zhou, K Zhou, K Zhou, L Logie, L Wu, LC Gormsen, LJ McCreight, LX Cubeddu, M Foretz, M Johanns, M Massollo, MD Fullerton, MF Vincent, MR Owen, MY El-Mir, NR Shin, P Repiscak, PA Lochhead, RA DeFronzo, RA Miller, SA Hawley, SB Vasamsetti, SH Koo, T Dujic, T Dujic, X Quan, Y Shu   +58 more
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The effect of concomitant DPPIVi use on glycaemic control and hypoglycaemia with insulin glargine 300 U/mL (Gla-300) versus insulin glargine 100 U/mL (Gla-100) in people with type 2 diabetes: A patient-level meta-analysis of EDITION 2 and 3 [PDF]

, 2018
Aims To evaluate the effect of concomitant dipeptidyl peptidase IV inhibitor (DPPIVi) use on efficacy and safety of insulin glargine 300 U/mL (Gla-300) versus glargine 100 U/mL (Gla-100) in people with type 2 diabetes on oral antihyperglycaemic drugs ...
Brito-Sanfiel, Miguel, Buzzetti, Raffaella, Chevalier, Soazig, Lavalle-Gonzalez, Fernando, Merino-Trigo, Ana, Pettus, Jeremy Hodson, Stella, Peter, Yale, Jean-François   +7 more
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Disruption of BASIGIN decreases lactic acid export and sensitizes non-small cell lung cancer to biguanides independently of the LKB1 status [PDF]

, 2014
Most cancers rely on aerobic glycolysis to generate energy and metabolic intermediates. To maintain a high glycolytic rate, cells must efficiently export lactic acid through the proton-coupled monocarboxylate transporters (MCT1/4).
Baltazar, Fátima, Granja, Sara Costa, Le Floch, Renaud, Marchiq, Ibtissam, Moura, Conceição Souto, Pouysségur, Jacques   +5 more
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Dietary Behaviors Among Patients with Type 2 Diabetes Mellitus in YOGYAKARTA, Indonesia [PDF]

, 2011
Purpose: To describe dietary behaviors and examine relationships between selected factors and dietary behaviors among type 2 diabetes mellitus (T2DM) patients in Yogyakarta, Indonesia.Method: Seventy T2DM patients from a hospital in Yogyakarta who met ...
Kritpracha, C. (Charuwan), Primanda, Y. (Yanuar), Thaniwattananon, P. (Ploenpit)   +2 more
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Medication utilization patterns among type 2 diabetes patients initiating Exenatide BID or insulin glargine: a retrospective database study [PDF]

, 2013
BACKGROUND: Type 2 diabetes is a common and costly illness, associated with significant morbidity and mortality. Despite this, there is relatively little information on the ‘real-world’ medication utilization patterns for patients with type 2 diabetes ...
Barbara Johnson, Byron Hoogwerf, Gregory Lenhart, Machaon Bonafede, Manjiri Pawaskar, Robert Fowler   +5 more
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The effect of metformin on biomarkers associated with breast cancer outcomes: a systematic review, meta-analysis, and dose–response of randomized clinical trials [PDF]

, 2020
Purpose: Breast cancer is a leading cause of cancer mortality in developed countries. We performed a meta-analysis of randomized clinical trials to investigate the effect of metformin on biomarkers associated with breast cancer outcomes and to explore ...
Chhabra, M., Clark, C., Gudi, S. K., Manzari, N., Mousavi, S. M., Naik, G., Rahmani, J., Thompson, J., Varkaneh, H. K., Zhang, Y.   +9 more
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AMPK:a target for drugs and natural products with effects on both diabetes and cancer [PDF]

, 2013
The AMP-activated protein kinase (AMPK) is a highly conserved sensor of cellular energy that appears to have arisen at an early stage during eukaryotic evolution.
Chen, Cool, Corton, D. G. Hardie, Davies, Davies, El-Mir, Foretz, Greer, Hardie, Hardie, Hawley, Hawley, Hawley, Hawley, Huang, Hwang, Imamura, Jaleel, Ji, Jones, Liang, Lin, Lochhead, Lowell, Miners, Mooney, Musi, Oakhill, Rothwell, Rothwell, Scott, Stahmann, Suissa, Thaler, Timmers, Vara, Vincent, Woods, Woods, Xiao, Xiao, Yang, Yin   +43 more
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The welfare impact of parallel imports: A structural approach applied to the German market for oral anti-diabetics [PDF]

, 2014
We investigate the welfare impact of parallel imports using a large panel data set containing monthly information on sales, ex-factory prices, and further product characteristics for all 700 anti-diabetic drugs sold in Germany between 2004 and 2010.
Duso, Tomaso, Herr, Annika, Suppliet, Moritz   +2 more
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The thermodynamics of metabolism, cardiovascular performance and exercise, in health and diabetes: The objective of clinical markers [PDF]

, 2013
Extensive experience in UK National Health Service metabolic syndrome/type 2 diabetes clinics highlights the need for convenient clinical marker(s) which can be readily used to indicate the success or otherwise of alternative therapies.
Atherton, MA, Collins, MW, González-Alonso, J, König, CS, Ramachandran, S   +4 more
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