Results 31 to 40 of about 9,814 (230)

Quantitative determination of 0.05 % chlorhexidine solution by capillary electrophoresis

Zaporožskij Medicinskij Žurnal, 2019
The aim of the work was to estimate the quantitative content of 0.05 % chlorhexidine solution by capillary electrophoresis. Materials and methods.
A. M. Sampiiev, N. A. Davitavian, Ye. B. Nikiforova, Yu. F. Yakuba   +3 more
doaj   +1 more source

Development of antitumor biguanides targeting energy metabolism and stress responses in the tumor microenvironment

Scientific Reports, 2021
To develop antitumor drugs capable of targeting energy metabolism in the tumor microenvironment, we produced a series of potent new biguanide derivatives via structural modification of the arylbiguanide scaffold.
Takayuki Sakai, Yoshiyuki Matsuo, Kensuke Okuda, Kiichi Hirota, Mieko Tsuji, Tasuku Hirayama, Hideko Nagasawa   +6 more
doaj   +1 more source

Initial combination therapy for patients with type 2 diabetes mellitus: considerations for metformin plus linagliptin

Drugs in Context, 2013
For patients with type 2 diabetes mellitus, management of hyperglycemia is typically complex, and few patients successfully achieve and maintain recommended targets for glycated hemoglobin (HbA1c).
Jeffrey Freeman
doaj   +1 more source

Activity of Certain Aryl-Substituted Biguanides as Accelerators of Vulcanization

, 1928
Aryl-substituted biguanides are rubber vulcanization accelerators of moderate activity. The relation between the chemical constitution of the substituted radicals and the activity of the biguanides is, in general, about the same as found by other ...
G. B. L. Smith, A. J. Weiss
core   +1 more source

Mild Biamidine-Transfer Conditions for the Synthesis of Aliphatic Biguanides

SynOpen, 2021
This study focuses on the development of new synthetic pathways to monosubstituted biguanides from amines. An exhaustive comparison of the conditions and reagents used for biamidine transfer was performed.
Rostyslav Bardovskyi, Marie Fabre, Cyril Ronco, Rachid Benhida   +3 more
doaj   +1 more source

Mechanisms of NMDA Receptor Inhibition by Biguanide Compounds

Pharmaceuticals
N-methyl-D-aspartate (NMDA) receptors are inhibited by many medicinal drugs. The recent successful repurposing of NMDA receptor antagonists ketamine and dextromethorphan for the treatment of major depressive disorder further enhanced the interest in this
Arseniy S. Zhigulin, Anastasiya O. Novikova, Oleg I. Barygin   +2 more
doaj   +1 more source

Synthesis of Biguanides as Potential hypoglycemic Agents: Some heterocyclic Derivatives

, 1966
Synthesis of Biguanides as Potential hypoglycemic Agents: Some heterocyclic ...
Auditi Kumar Acharyya, U. P. Basu, D. N. Ray   +2 more
core   +1 more source

Trends in the utilization, expenditure and costs of noninsulin glucose‐lowering drugs in the Medicaid population: Steady increases in glucagon‐like peptide‐1 receptor agonist and sodium–glucose transporter‐2 inhibitor use, prices and expenditure

British Journal of Clinical Pharmacology, EarlyView.
Aims This study aimed to analyse changes in the utilization, expenditure and average cost of noninsulin glucose‐lowering drugs (GLDs) between 2008 and 2023. Methods This was a retrospective observational study of 2008–2023 data from the National Medicaid State Drug Utilization database.
Rawan O. Almadfaa
wiley   +1 more source

Metformin and Other Biguanides in Oncology: Advancing the Research Agenda

, 2010
Retrospective studies that may be impractical to confirm prospectively suggest that diabetics treated with metformin have a substantially reduced cancer burden compared with other diabetics.
Michael Pollak
core   +1 more source

Current practice and guideline adherence in renal dose adjustment for patients with chronic kidney disease: A systematic review and meta‐analysis

British Journal of Clinical Pharmacology, EarlyView.
Aims To quantify prescribing adherence to renal dosing recommendations in adults with chronic kidney disease (CKD; Stage 3 and above) and to evaluate the clinical consequences of non‐adherence. Methods This systematic review and meta‐analysis was conducted in accordance with PRISMA 2020 guidelines and registered in PROSPERO (CRD42025620883).
Hager ElGeed, Ahmed Tehemar, Mohamed Gasimelseed, Ahmed Gharaibeh, Muhammad Abdul Hadi, Kazeem Yusuff, Amani Zidan, Ahmed Awaisu   +7 more
wiley   +1 more source