Results 31 to 40 of about 8,184 (204)

Positional Isomer Engineering for Crystallization Kinetics Control in Wide‐Bandgap Perovskite Solar Cells

Carbon Energy, EarlyView.
Based on the ortho‐para configuration of the amino‐sulfonic acid group, 2,4‐diaminobenzenesulfonic acid (2,4‐DABSA) forms the strongest coordination with the perovskite precursor among its isomers, guiding a unique “fast nucleation followed by slow crystallization” kinetics.
Jun Chu, Chaoqi Liu, Xi Yang, Xiuhua Chen, Tao Zhu, Shaoyuan Li, Zhongqiu Tong, Huidong Ma, Jianjun Zhang, Jianghui Zheng, Wenhui Ma, Jessica Yajie Jiang   +11 more
wiley   +1 more source

Inhibition of Chloride Intracellular Channel 1 (CLIC1) as Biguanide Class-Effect to Impair Human Glioblastoma Stem Cell Viability

Frontiers in Pharmacology, 2018
The antidiabetic biguanide metformin exerts antiproliferative effects in different solid tumors. However, during preclinical studies, metformin concentrations required to induce cell growth arrest were invariably within the mM range, thus difficult to ...
Federica Barbieri, Roberto Würth, Alessandra Pattarozzi, Ivan Verduci, Chiara Mazzola, Maria G. Cattaneo, Michele Tonelli, Agnese Solari, Adriana Bajetto, Antonio Daga, Lucia M. Vicentini, Michele Mazzanti, Tullio Florio, Tullio Florio   +13 more
doaj   +1 more source

Insulin Resistance: An Update on Biochemical and Pathophysiological Mechanisms and Impact on Various Diseases

iNew Medicine, EarlyView.
ABSTRACT Insulin resistance is the biological phenomenon in which the human body's normal response to the metabolic hormone insulin is compromised. Insulin is a regulator of most of the essential metabolic steps in the body that control energy homoeostasis, so dysregulation leads to multiple diverse human diseases including, most prominently, Type 2 ...
Peter J. Little, Stefan Offermanns, Haaglim Cho, Zhiping Liu, Pinglian Yang, Qiaozhu Su, Henry Wade, Wah Yang, Danielle Kamato, Neale Cohen, Alex Bobik, Iqra Ilyas, Suowen Xu   +12 more
wiley   +1 more source

The role of pharmacogenetics in the treatment of diabetes mellitus [PDF]

Journal of Medical Biochemistry, 2014
Diabetes mellitus is a heterogeneous group of disorders in which particular disease phenotypes can be characterized by a specific etiology and/or pathogenesis of the disease, but in many cases its classification is greatly impeded due to significant ...
Topić Elizabeta
doaj  

Role of Mitochondria in the Mechanism(s) of Action of Metformin

Frontiers in Endocrinology, 2019
Metformin is a drug from the biguanide family that is used for decades as the first-line therapeutic choice for the treatment of type 2 diabetes. Despite its worldwide democratization, owing to its clinical efficacy, high safety profile and cheap cost ...
Guillaume Vial, Guillaume Vial, Dominique Detaille, Bruno Guigas   +3 more
doaj   +1 more source

Correlations Among Glycemia and Glucose Variability, Thyroid Hormones, and Albuminuria in Patients With Type 2 Diabetes Mellitus

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Hyperglycemia, glucose fluctuations, and thyroid dysfunction contribute to the progression of diabetic nephropathy. This study aimed to investigate the associations of glycemia, glucose variability, and thyroid hormones with albuminuria in patients with type 2 diabetes mellitus (T2DM). In total, 451 T2DM patients were included.
Na Luo, Shang‐Yong Feng, Hui Chen, Dun‐Min She, Yan Liu, Ying Li, Cai‐Feng Yan, Zhen‐Wen Zhang, Jing Chen, Xiao‐Li Cai, Gao‐Yu Zhao, Hui Yu, Yan Wang   +12 more
wiley   +1 more source

Sexual Safety Signals of Common Antidiabetic Drugs: Insights From FAERS Disproportionality Analysis

Andrology, EarlyView.
ABSTRACT Background Erectile dysfunction is a prevalent and distressing complication of diabetes mellitus that markedly affects quality of life in male patients. Although the role of diabetes in erectile dysfunction is well‐established, potential drug‐induced sexual dysfunction associated with commonly prescribed antidiabetic medications remains ...
Shan Lin, Xuefeng Ding, Xin Dang, Qingyuan Zhan   +3 more
wiley   +1 more source

Retrospective nationwide study on the trends in first‐line antidiabetic medication for patients with type 2 diabetes in Japan

Journal of Diabetes Investigation, 2022
Aims/Introduction To investigate the national trend in the prescription of first‐line non‐insulin antidiabetic agents and total medical costs (TMCs) after prescribing the drug in Japanese patients with type 2 diabetes.
Ryotaro Bouchi, Takehiro Sugiyama, Atsushi Goto, Kenjiro Imai, Noriko Ihana‐Sugiyama, Mitsuru Ohsugi, Toshimasa Yamauchi, Takashi Kadowaki, Kohjiro Ueki   +8 more
doaj   +1 more source

Chlorhexidine 0.02% or polyhexamethylene biguanide 0.02% as the main treatment for Acanthamoeba keratitis

Acta Ophthalmologica, EarlyView.
Abstract Purpose To report medical cure and treatment failure rates of Acanthamoeba keratitis (AK) with respect to type of treatment, disease stage and prognostic factors. Methods Electronic records were reviewed for 45 patients with PCR‐positive AK treated at the Department of Ophthalmology, Aarhus University Hospital, Denmark from 2012 to 2025 ...
Anders Ivarsen, Sandra M. Skovdal, Stine Elkjær Nielsen, Christen Rune Stensvold, Henrik Vedel Nielsen, Jesper Hjortdal   +5 more
wiley   +1 more source

Disorder of Glucose Metabolism and Therapy: Implications on the Natural History of Advanced Chronic Liver Disease

GE: Portuguese Journal of Gastroenterology
Introduction: Hepatogenous diabetes (HD) is a disorder of glucose metabolism (DGM) that develops as a complication of advanced chronic liver disease (ACLD) with an estimated prevalence of 20–70%.
Sofia Garcês Soares, Tereza Frazão, Célia Tuna, Margarida Montes, Ana Rocha, Lígia Rodrigues Santos, Paulo Carrola, Sónia Carvalho, Inês Pinho, Luís Nogueira, Manuel Marques-Cruz, José Presa   +11 more
doaj   +1 more source