Results 31 to 40 of about 9,205 (230)

Molecular features of biguanides required for targeting of mitochondrial respiratory complex I and activation of AMP-kinase. [PDF]

, 2016
BACKGROUND: The biguanides are a family of drugs with diverse clinical applications. Metformin, a widely used anti-hyperglycemic biguanide, suppresses mitochondrial respiration by inhibiting respiratory complex I. Phenformin, a related anti-hyperglycemic

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Characteristics of new users of dipeptidyl peptidase-4 inhibitors and biguanides. [PDF]

, 2018
Characteristics of new users of dipeptidyl peptidase-4 inhibitors and biguanides.
Ian C. K. Wong (306894), Kenneth K. C. Man (6078836), Paul Stang (3414047), Yea-Huei Kao Yang (528537), Yukari Kamijima (5721233), Kiyoshi Kubota (561420), Patrick Ryan (532054), Chien-Chou Su (6078839), Soko Setoguchi (427043), Shinya Kimura (247648), Edward Chia-Cheng Lai (528535), Martijn Schuemie (505609), Yinghong Zhang (6078842)   +12 more
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Genotypic and Phenotypic Factors Influencing Drug Response in Mexican Patients With Type 2 Diabetes Mellitus

Frontiers in Pharmacology, 2018
The treatment of Type 2 Diabetes Mellitus (T2DM) consists primarily of oral antidiabetic drugs (OADs) that stimulate insulin secretion, such as sulfonylureas (SUs) and reduce hepatic glucose production (e.g., biguanides), among others.
Hector E. Sanchez-Ibarra, Luisa M. Reyes-Cortes, Xian-Li Jiang, Claudia M. Luna-Aguirre, Dionicio Aguirre-Trevino, Ivan A. Morales-Alvarado, Rafael B. Leon-Cachon, Fernando Lavalle-Gonzalez, Faruck Morcos, Faruck Morcos, Hugo A. Barrera-Saldaña, Hugo A. Barrera-Saldaña   +11 more
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Related Articles / Press Coverage from Metformin and Other Biguanides in Oncology: Advancing the Research Agenda [PDF]

, 2010
Related Articles / Press Coverage from Metformin and Other Biguanides in Oncology: Advancing the Research ...
Michael Pollak (11169)
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Development of antitumor biguanides targeting energy metabolism and stress responses in the tumor microenvironment

Scientific Reports, 2021
To develop antitumor drugs capable of targeting energy metabolism in the tumor microenvironment, we produced a series of potent new biguanide derivatives via structural modification of the arylbiguanide scaffold.
Takayuki Sakai, Yoshiyuki Matsuo, Kensuke Okuda, Kiichi Hirota, Mieko Tsuji, Tasuku Hirayama, Hideko Nagasawa   +6 more
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Ether lipid biosynthesis promotes lifespan extension and enables diverse pro-longevity paradigms in Caenorhabditis elegans

eLife, 2023
Biguanides, including the world’s most prescribed drug for type 2 diabetes, metformin, not only lower blood sugar, but also promote longevity in preclinical models.
Lucydalila Cedillo, Fasih M Ahsan, Sainan Li, Nicole L Stuhr, Yifei Zhou, Yuyao Zhang, Adebanjo Adedoja, Luke M Murphy, Armen Yerevanian, Sinclair Emans, Khoi Dao, Zhaozhi Li, Nicholas D Peterson, Jeramie Watrous, Mohit Jain, Sudeshna Das, Read Pukkila-Worley, Sean P Curran, Alexander A Soukas   +18 more
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Type 2 Diabetes in Neuroendocrine Tumors: Are Biguanides and Statins Part of the Solution? [PDF]

, 2018
Context Biguanides and statins exert beneficial effects on various cancer types. Their precise effects and underlying molecular mechanisms are poorly understood.
Herrera-Martinez, Aura D, Luque, Raúl M., Castaño, Justo P, Gahete, Manuel D, Galvez-Moreno, Maria A, Pedraza-Arévalo, Sergio, Gahete, Manuel D., Gálvez-Moreno, María A., Castaño, Justo P., Herrera-Martínez, Aura D., L-López, Fernando, Luque, Raul M   +11 more
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Quantitative determination of 0.05 % chlorhexidine solution by capillary electrophoresis

Zaporožskij Medicinskij Žurnal, 2019
The aim of the work was to estimate the quantitative content of 0.05 % chlorhexidine solution by capillary electrophoresis. Materials and methods.
A. M. Sampiiev, N. A. Davitavian, Ye. B. Nikiforova, Yu. F. Yakuba   +3 more
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Initial combination therapy for patients with type 2 diabetes mellitus: considerations for metformin plus linagliptin

Drugs in Context, 2013
For patients with type 2 diabetes mellitus, management of hyperglycemia is typically complex, and few patients successfully achieve and maintain recommended targets for glycated hemoglobin (HbA1c).
Jeffrey Freeman
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Mild Biamidine-Transfer Conditions for the Synthesis of Aliphatic Biguanides

SynOpen, 2021
This study focuses on the development of new synthetic pathways to monosubstituted biguanides from amines. An exhaustive comparison of the conditions and reagents used for biamidine transfer was performed.
Rostyslav Bardovskyi, Marie Fabre, Cyril Ronco, Rachid Benhida   +3 more
doaj   +1 more source