Results 51 to 60 of about 9,814 (230)

Role of Mitochondria in the Mechanism(s) of Action of Metformin

Frontiers in Endocrinology, 2019
Metformin is a drug from the biguanide family that is used for decades as the first-line therapeutic choice for the treatment of type 2 diabetes. Despite its worldwide democratization, owing to its clinical efficacy, high safety profile and cheap cost ...
Guillaume Vial, Guillaume Vial, Dominique Detaille, Bruno Guigas   +3 more
doaj   +1 more source

Analyses of biguanides and related compounds in biological and environmental samples by HPLC

, 2015
Biguanides are nitrogen containing compounds and classified as antidiabetic (metformin, phenformin, buformin), antimalarial (proguanil, cycloproguanil, 4-chlorophenyl biguanide), and antimicrobial (chlorhexidine, polyhexamethylene biguanide) drugs. These
Hussain, Iqbal, Aboul-Enein, Hassan Y., Sanagi, Mohd. Marsin, Ali, Imran, Ibrahim, Wan Aini Wan   +4 more
core   +1 more source

Correlations Among Glycemia and Glucose Variability, Thyroid Hormones, and Albuminuria in Patients With Type 2 Diabetes Mellitus

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Hyperglycemia, glucose fluctuations, and thyroid dysfunction contribute to the progression of diabetic nephropathy. This study aimed to investigate the associations of glycemia, glucose variability, and thyroid hormones with albuminuria in patients with type 2 diabetes mellitus (T2DM). In total, 451 T2DM patients were included.
Na Luo, Shang‐Yong Feng, Hui Chen, Dun‐Min She, Yan Liu, Ying Li, Cai‐Feng Yan, Zhen‐Wen Zhang, Jing Chen, Xiao‐Li Cai, Gao‐Yu Zhao, Hui Yu, Yan Wang   +12 more
wiley   +1 more source

Développement d'une méthode d'analyse par spectrométrie de masse du mode d'action des biguanides dans le traitement du cancer [PDF]

, 2019
L’adénocarcinome pancréatique ductal (PDAC) est une des tumeurs solides les plus malignes retrouvées dans la population humaine actuelle. Plusieurs chercheurs s’intéressent donc à trouver un nouveau traitement efficace pour ce type de cancer.
Doré, Alexandra
core   +2 more sources

The biguanides metformin and phenformin inhibit angiogenesis, local and metastatic growth of breast cancer by targeting both neoplastic and microenvironment cells [PDF]

, 2014
The human white adipose tissue (WAT) contains progenitors with cooperative roles in breast cancer (BC) angiogenesis, local and metastatic progression. The biguanide Metformin (Met), commonly used for Type 2 diabetes, might have activity against BC and ...
Labanca, V., G. Gregato, D. M. Noonan, A. Calleri, Noonan, D., Talarico, G., Gregato, G., Douglas M. Noonan, Orecchioni, S., Adriana Albini, K. Dallaglio, Calleri, A., Bertolini, F., Katiuscia Dallaglio, Mancuso, P., Francesco Bertolini, F. Reggiani, Patrizia Mancuso, Angelica Calleri, P. Mancuso, A. Albini, Stefania Orecchioni, Francesca Reggiani, Giuliana Gregato, S. Orecchioni, F. Bertolini, Albini, A., G. Talarico, Giovanna Talarico, Dallaglio, K., Reggiani, F., Valentina Labanca, V. Labanca   +32 more
core   +1 more source

Senotherapeutics for Knee Osteoarthritis

Medicinal Research Reviews, EarlyView.
ABSTRACT Osteoarthritis (OA) is a chronic disease that imposes a significant economic burden and deteriorates quality of life. Nevertheless, current therapeutic options for OA are limited to symptomatic remedies. As such, there is a high interest in novel methods for treating or preventing OA.
Ezgi Duman, Girish Pattappa, Patrick Pann, Stephan Reppenhagen, Maximilian Rudert, Peter Angele, Denitsa Docheva   +6 more
wiley   +1 more source

Retrospective nationwide study on the trends in first‐line antidiabetic medication for patients with type 2 diabetes in Japan

Journal of Diabetes Investigation, 2022
Aims/Introduction To investigate the national trend in the prescription of first‐line non‐insulin antidiabetic agents and total medical costs (TMCs) after prescribing the drug in Japanese patients with type 2 diabetes.
Ryotaro Bouchi, Takehiro Sugiyama, Atsushi Goto, Kenjiro Imai, Noriko Ihana‐Sugiyama, Mitsuru Ohsugi, Toshimasa Yamauchi, Takashi Kadowaki, Kohjiro Ueki   +8 more
doaj   +1 more source

Male Sexual and Reproductive Health in Diabetes and Obesity Pharmacotherapy: A Source‐Triangulated Counseling Map

Andrology, EarlyView.
ABSTRACT Background Drugs used for diabetes and obesity increasingly shape male sexual and reproductive counseling, but clinical studies, trial registrations, regulatory labels, and patents answer different questions. Objectives The objective is to map these sources and define what each can support when counseling men receiving metabolic drugs ...
Marek Broul, Michal Dubský, Aneta Hujová, Michaela Liegertová   +3 more
wiley   +1 more source

Disorder of Glucose Metabolism and Therapy: Implications on the Natural History of Advanced Chronic Liver Disease

GE: Portuguese Journal of Gastroenterology
Introduction: Hepatogenous diabetes (HD) is a disorder of glucose metabolism (DGM) that develops as a complication of advanced chronic liver disease (ACLD) with an estimated prevalence of 20–70%.
Sofia Garcês Soares, Tereza Frazão, Célia Tuna, Margarida Montes, Ana Rocha, Lígia Rodrigues Santos, Paulo Carrola, Sónia Carvalho, Inês Pinho, Luís Nogueira, Manuel Marques-Cruz, José Presa   +11 more
doaj   +1 more source

Characteristics of new users of dipeptidyl peptidase-4 inhibitors and biguanides.

, 2018
Characteristics of new users of dipeptidyl peptidase-4 inhibitors and biguanides.
Ian C. K. Wong (306894), Kenneth K. C. Man (6078836), Paul Stang (3414047), Yea-Huei Kao Yang (528537), Yukari Kamijima (5721233), Kiyoshi Kubota (561420), Patrick Ryan (532054), Chien-Chou Su (6078839), Soko Setoguchi (427043), Shinya Kimura (247648), Edward Chia-Cheng Lai (528535), Martijn Schuemie (505609), Yinghong Zhang (6078842)   +12 more
core   +1 more source