Results 71 to 80 of about 8,184 (204)

Biguanides enhance antifungal activity against Candida glabrata

Virulence, 2018
Candida spp. are the fourth leading cause of nosocomial blood stream infections in North America. Candida glabrata is the second most frequently isolated species, and rapid development of antifungal resistance has made treatment a challenge.
Shuying Xu, Marianela Feliu, Allison K. Lord, Daniel P. Lukason, Paige E. Negoro, Nida S. Khan, Zeina Dagher, Michael B. Feldman, Jennifer L. Reedy, Samantha N. Steiger, Jenny M. Tam, Alexander A. Soukas, David B. Sykes, Michael K. Mansour   +13 more
doaj   +1 more source

A systematic review and meta‐analysis of the relative benefit of dual versus single oral hypoglycaemic therapy following diagnosis with type 2 diabetes (T2D)

Diabetic Medicine, Volume 43, Issue 7, July 2026.
Abstract Introduction Achieving and sustaining target glycated haemoglobin (HbA1c) levels is fundamental in the management of type 2 diabetes (T2D). We here aimed to assess whether initial dual oral therapy outperforms monotherapy in reaching glycaemic targets in patients with treatment‐naive or early‐stage T2D.
Mairead Kelly, Sushant Saluja, Hugh Logan Ellis, Sarah Jamil, Martin B. Whyte, Adrian Heald   +5 more
wiley   +1 more source

Prescribing pattern of antidiabetic drugs in urban population of Hyderabad

National Journal of Physiology, Pharmacy and Pharmacology, 2015
Background: Diabetes mellitus (DM) is a major public health problem in developing countries. Drug utilization study of antidiabetic drugs is of paramount importance to promote rational drug use in patients with DM and to make available valuable ...
Jamuna Rani, Sambasiva Reddy
doaj   +1 more source

Ueber Biguanid [PDF]

Berichte der deutschen chemischen Gesellschaft, 1879
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openaire   +2 more sources

Sitagliptin, Metformin and Glimepiride Fixed‐Dose Combination Compared to Co‐Administration of Metformin and High‐Dose Glimepiride in Indian Patients With Type 2 Diabetes: A Randomised, Double‐Blind, Double‐Dummy, Phase 3 Clinical Study

Diabetes, Obesity and Metabolism, Volume 28, Issue 7, Page 6207-6216, July 2026.
ABSTRACT Aims This study assessed the efficacy and safety of a triple fixed‐dose combination (FDC) of sitagliptin, metformin, and glimepiride versus co‐administered metformin and glimepiride in Indian patients with uncontrolled Type 2 diabetes (T2D).
Rakesh Sahay, Ambanna Gowda, Manish Kumar Singh, A. Gopal Rao, Ramesh Duraisamy, Dinesh Gangwani, Jitendra Shukla, Vikas Agarwal, Sandesh Sahebarao Patil, Ambrish C., Satish Babu K. N., Arvind Palawat, Sandip Krishnrao Gofne, Abhay Kumar Sahoo, Pradeep Kumar Rai, Raisa Shaikh, Shruti Saha, Dipak Patil, Pravin Ghadge, Piyush Patel, Lalit Lakhwani, Suyog Mehta, Sadhna Joglekar   +22 more
wiley   +1 more source

Amlodipine and valsartan improving effect on the survival rate and deleterious pathological changes in streptozotocin-induced diabetic rats treated with metformin

Pharmaceutical and Biomedical Research, 2019
Diabetes mellitus (DM) and hypertension usually co-exist, and when this happens, the prognosis would be worse than each disease alone. Given this, we evaluated the possible effects of valsartan and amlodipine administration on metformin-treated diabetic ...
Israel Olapeju Bolanle, Eric Kelly Inanemo Omogbai, Enitome Bafor   +2 more
doaj  

Glucose Deprivation Enhances the Antiproliferative Effects of Oral Hypoglycemic Biguanides in Different Molecular Subtypes of Breast Cancer: an in Vitro Study

Acta Pharmaceutica, 2018
Extensive in vitro studies have been conducted to evaluate the anticancer activity of oral hypoglycemic agents. Many of these studies experienced detrimental limitations, since they were conducted on cancer cells commonly grown in culture media ...
Bardaweel Sanaa K., Alsalamat Husam A., Aleidi Shereen M., Bashatwah Rasha M.   +3 more
doaj   +1 more source

Effects of Hyperglycemia and Iron Deficiency on Kidney and Heart Function in Type 2 Diabetes Disease

Biomolecules & Biomedicine, 2006
Untreated anemia can caused significant cardiac and kidney damage. The aim of this study was to investigate the efficiency of anemia and hyperglycemia treatment in type 2 diabetes and their impact on kidney and heart impairment.
Belma Aščić-Buturović, Bećir Heljić   +1 more
doaj   +1 more source

Oxoaporphine‐Metformin Rhodium(III) Hybrid Ionic Complex With Antidiabetes and Anticancer Effects: New Insights From DFT Computations

International Journal of Quantum Chemistry, Volume 126, Issue 12, June 15, 2026.
DFT (GGA) analysis reveals that the Rh‐Met metallodrug forms a stable ionic pair driven by a network of supramolecular interactions. QTAIM and IGMH insights elucidate the quantum‐mechanical nature of intra‐ and intermolecular contacts governing its self‐assembly and structural organization in the crystal. ABSTRACT A recently proposed (J. Am. Chem. Soc.
Costantino Zazza, Nico Sanna, Felice Grandinetti   +2 more
wiley   +1 more source

Biguanides Induce Acute de novo Lipogenesis in Human Primary Sebocytes

Clinical, Cosmetic and Investigational Dermatology, 2020
James Nicoll, Benjamin M Buehrer Zen-Bio, Inc., Research Triangle Park, NC, USACorrespondence: Benjamin M BuehrerZen-Bio, Inc., 3200 East Highway 54, Suite 100, PO Box 13888, Research Triangle Park, NC 27709, USATel +1 919 547 0692Fax +1 919 547 ...
Nicoll J, Buehrer BM
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