Results 61 to 70 of about 9,205 (230)

The biguanides metformin and phenformin inhibit angiogenesis, local and metastatic growth of breast cancer by targeting both neoplastic and microenvironment cells [PDF]

, 2014
The human white adipose tissue (WAT) contains progenitors with cooperative roles in breast cancer (BC) angiogenesis, local and metastatic progression. The biguanide Metformin (Met), commonly used for Type 2 diabetes, might have activity against BC and ...
Labanca, V., G. Gregato, D. M. Noonan, A. Calleri, Noonan, D., Talarico, G., Gregato, G., Douglas M. Noonan, Orecchioni, S., Adriana Albini, K. Dallaglio, Calleri, A., Bertolini, F., Katiuscia Dallaglio, Mancuso, P., Francesco Bertolini, F. Reggiani, Patrizia Mancuso, Angelica Calleri, P. Mancuso, A. Albini, Stefania Orecchioni, Francesca Reggiani, Giuliana Gregato, S. Orecchioni, F. Bertolini, Albini, A., G. Talarico, Giovanna Talarico, Dallaglio, K., Reggiani, F., Valentina Labanca, V. Labanca   +32 more
core   +1 more source

Développement d'une méthode d'analyse par spectrométrie de masse du mode d'action des biguanides dans le traitement du cancer [PDF]

, 2019
L’adénocarcinome pancréatique ductal (PDAC) est une des tumeurs solides les plus malignes retrouvées dans la population humaine actuelle. Plusieurs chercheurs s’intéressent donc à trouver un nouveau traitement efficace pour ce type de cancer.
Doré, Alexandra
core   +4 more sources

Chlorhexidine 0.02% or polyhexamethylene biguanide 0.02% as the main treatment for Acanthamoeba keratitis

Acta Ophthalmologica, EarlyView.
Abstract Purpose To report medical cure and treatment failure rates of Acanthamoeba keratitis (AK) with respect to type of treatment, disease stage and prognostic factors. Methods Electronic records were reviewed for 45 patients with PCR‐positive AK treated at the Department of Ophthalmology, Aarhus University Hospital, Denmark from 2012 to 2025 ...
Anders Ivarsen, Sandra M. Skovdal, Stine Elkjær Nielsen, Christen Rune Stensvold, Henrik Vedel Nielsen, Jesper Hjortdal   +5 more
wiley   +1 more source

Disorder of Glucose Metabolism and Therapy: Implications on the Natural History of Advanced Chronic Liver Disease

GE: Portuguese Journal of Gastroenterology
Introduction: Hepatogenous diabetes (HD) is a disorder of glucose metabolism (DGM) that develops as a complication of advanced chronic liver disease (ACLD) with an estimated prevalence of 20–70%.
Sofia Garcês Soares, Tereza Frazão, Célia Tuna, Margarida Montes, Ana Rocha, Lígia Rodrigues Santos, Paulo Carrola, Sónia Carvalho, Inês Pinho, Luís Nogueira, Manuel Marques-Cruz, José Presa   +11 more
doaj   +1 more source

Perioperative glycaemic profiles in Aboriginal and Torres Strait Islander people with diabetes mellitus

Diabetic Medicine, EarlyView.
This large multicentre retrospective cohort study in Australia revealed that despite being younger and having greater preoperative comorbidity and higher HbA1c levels, Aboriginal and Torres Strait Islander adults with diabetes mellitus demonstrate higher rates of perioperative hypoglycaemia, but otherwise comparable markers of glycaemic variability and
Katerina Flabouris, Odette R. Pearson, Kim Morey, Suzanne M. Edwards, David R. Jesudason, Chinmay S. Marathe   +5 more
wiley   +1 more source

Phenylethynylbenzyl-modified biguanides inhibit pancreatic cancer tumor growth

Scientific Reports, 2021
We present the design and synthesis of a small library of substituted biguanidium salts and their capacity to inhibit the growth of pancreatic cancer cells.
Audrey Hébert, Maxime Parisotto, Marie-Camille Rowell, Alexandra Doré, Ana Fernandez Ruiz, Guillaume Lefrançois, Paloma Kalegari, Gerardo Ferbeyre, Andreea R. Schmitzer   +8 more
doaj   +1 more source

Design, synthesis, biological evaluation and toxicity studies of N,N-disubstituted biguanides as quorum sensing inhibitors [PDF]

, 2015
A series of novel N,N-disubstituted biguanides (8a–8j) have been synthesized using varied secondary amines and cyanoguanidine under microwave irradiation.
Bhatia, Sonam, Bharatam, Prasad V., Singh, Shaminder, Chakraborti, Asit K., Sonwane, Vijay C., Wanjari, Pravin J.   +5 more
core   +1 more source

The Pituitary Gland is a Novel Major Site of Action of Metformin in Non-Human Primates: a Potential Path to Expand and Integrate Its Metabolic Actions

Cellular Physiology and Biochemistry, 2018
Background/Aims: Biguanides are anti-hyperglycaemic agents used to treat diabetes by acting primarily on the liver, inhibiting hepatic gluconeogenesis. However, biguanides may target other key metabolic tissues to exert beneficial actions. As the “master
Mari C. Vázquez-Borrego, Antonio C. Fuentes-Fayos, Manuel D. Gahete, Justo P. Castaño, Rhonda D. Kineman, Raúl M. Luque   +5 more
doaj   +1 more source

Metal Chelate Complexes of the Condensation Products of Biguanides and Salicylaldehyde : Part I. Copper Compounds [PDF]

, 1968
Biguanide and mono-substituted biguanides condense with salicylaldehyde to give compounds of the Schiff base type. The resultant ligands give inner-metallic complexes with transitional metals and different types of complexes are obtained under different ...
A. K. Sarkar, S. N. Poddar
core   +1 more source

Comparison of decision tree with common machine learning models for prediction of biguanide and sulfonylurea poisoning in the United States: an analysis of the National Poison Data System

BMC Medical Informatics and Decision Making, 2023
Background Biguanides and sulfonylurea are two classes of anti-diabetic medications that have commonly been prescribed all around the world. Diagnosis of biguanide and sulfonylurea exposures is based on history taking and physical examination; thus ...
Omid Mehrpour, Farhad Saeedi, Samaneh Nakhaee, Farbod Tavakkoli Khomeini, Ali Hadianfar, Alireza Amirabadizadeh, Christopher Hoyte   +6 more
doaj   +1 more source