Results 41 to 50 of about 9,814 (230)

Target engagement of biguanides in colorectal carcinoma

Discover Chemistry
Colorectal cancer (CRC) continues to be the largest reason for disease-related illnesses and fatalities globally, emphasizing the critical necessity finding new along with affordable therapy approaches.
Poulami Patra, Rajat Subhra Dutta, Supriya Sahu   +2 more
doaj   +1 more source

Metformin: Focus on Melanoma

Frontiers in Endocrinology, 2018
Metformin is the most common biguanide used in the treatment of diabetes, with 120 million treated patients worldwide. Metformin decreases hyperglycemia without inducing hypoglycemia in diabetic patients and is very well tolerated.
Emilie Jaune, Emilie Jaune, Stéphane Rocchi, Stéphane Rocchi   +3 more
doaj   +1 more source

The chemistry of biguanides: from synthetic routes to applications in organic chemistry [PDF]

, 2019
In this mini review, we focus on the chemistry and applications of biguanides. We summarize the type and preparation of biguanides, and their applications as superbases and ligands in catalysis.The accepted manuscript in pdf format is listed with the ...
Schmitzer, Andreea, Fortun, Solne
core   +1 more source

Safety outcomes of antidiabetic medications: A comprehensive review of the EU summaries of product characteristics and international clinical practice guidelines

British Journal of Clinical Pharmacology, EarlyView.
Aims Information on the safety profile of antidiabetic medications is essential for informed treatment decisions in type 2 diabetes mellitus. Although this information is available in regulatory documents of individual drugs, a comprehensive overview across all approved antidiabetics is lacking.
David Liang, Daniala L. Weir, Safana Thevasahayam, Vera H. M. Deneer, Arno Siebes, Helga Gardarsdottir   +5 more
wiley   +1 more source

Recent Developments in Diabetes Management: Exploring Receptors, Pathways, and Compounds

BIO Integration
Diabetes mellitus (DM) is a widespread metabolic disorder with profound effects on vital organs. Often referred to as a “systemic” or “multi-organ” disorder due to the impact on key organs, such as the kidneys, pancreas, eyes, and heart, DM is ...
Pallavi Pandey, Vikash Jakhmola, Supriyo Saha, Anand Gaurav   +3 more
doaj   +1 more source

Biguanides Exert Antitumoral Actions in Pituitary Tumor Cells Through AMPK-Dependent and -Independent Mechanisms [PDF]

, 2019
[Context] Pituitary neuroendocrine tumors (PitNETs) are a commonly underestimated pathology in terms of incidence and associated morbimortality. Currently, an appreciable subset of patients are resistant or poorly responsive to the main current medical ...
López, Fernando L., Blanco-Acevedo, Cristóbal, Moreno-Moreno, Paloma, Venegas Moreno, Eva, Dios Fuentes, Elena, Fuentes-Fayos, Antonio C., Alhambra-Expósito, María R., Castaño, Justo P., Dios, Elena, Venegas-Moreno, Eva, Herrera-Martinez, Aura D, Vázquez-Borrego, Mari C., Luque, Raúl M., Ibáñez-Costa, Alejandro, Soto-Moreno, Alfonso, Vazquez-Borrego, Mari C, Fuentes-Fayos, Antonio C, Alhambra-Exposito, Maria R, Galvez-Moreno, Maria A, Barrera-Martín, Ana, Herrera-Martínez, Aura D., Solivera, Juan, Luque, Raul M, Castaño, Justo P, Gahete, Manuel D, L-Lopez, Fernando, Gahete, Manuel D., Gálvez-Moreno, María Ángeles   +27 more
core   +1 more source

Positional Isomer Engineering for Crystallization Kinetics Control in Wide‐Bandgap Perovskite Solar Cells

Carbon Energy, EarlyView.
Based on the ortho‐para configuration of the amino‐sulfonic acid group, 2,4‐diaminobenzenesulfonic acid (2,4‐DABSA) forms the strongest coordination with the perovskite precursor among its isomers, guiding a unique “fast nucleation followed by slow crystallization” kinetics.
Jun Chu, Chaoqi Liu, Xi Yang, Xiuhua Chen, Tao Zhu, Shaoyuan Li, Zhongqiu Tong, Huidong Ma, Jianjun Zhang, Jianghui Zheng, Wenhui Ma, Jessica Yajie Jiang   +11 more
wiley   +1 more source

Inhibition of Chloride Intracellular Channel 1 (CLIC1) as Biguanide Class-Effect to Impair Human Glioblastoma Stem Cell Viability

Frontiers in Pharmacology, 2018
The antidiabetic biguanide metformin exerts antiproliferative effects in different solid tumors. However, during preclinical studies, metformin concentrations required to induce cell growth arrest were invariably within the mM range, thus difficult to ...
Federica Barbieri, Roberto Würth, Alessandra Pattarozzi, Ivan Verduci, Chiara Mazzola, Maria G. Cattaneo, Michele Tonelli, Agnese Solari, Adriana Bajetto, Antonio Daga, Lucia M. Vicentini, Michele Mazzanti, Tullio Florio, Tullio Florio   +13 more
doaj   +1 more source

A comparative analysis of the prevalence of medicine classes and polypharmacy between community‐dwelling and residential aged care populations in Western Australia

Journal of Pharmacy Practice and Research, EarlyView.
Abstract Background Polypharmacy is a global issue, particularly among residential aged care home (RACH) residents with multimorbidity and complex care needs. However, population‐level evidence on longitudinal trends and comparisons with community‐dwelling (CD) older adults remains limited.
David Lim, Ninh Ha, David Youens, Rachael Moorin, Andrew Stafford   +4 more
wiley   +1 more source

The role of pharmacogenetics in the treatment of diabetes mellitus [PDF]

Journal of Medical Biochemistry, 2014
Diabetes mellitus is a heterogeneous group of disorders in which particular disease phenotypes can be characterized by a specific etiology and/or pathogenesis of the disease, but in many cases its classification is greatly impeded due to significant ...
Topić Elizabeta
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