Results 41 to 50 of about 9,205 (230)

Synthesis and Coordination Chemistry of 3,4-Ethylene-Bridged 1,1,2,5-Tetrasubstituted Biguanides [PDF]

, 2020
The synthesis of 3,4-ethylene-bridged 1,1,2,5-tetrasubstituted biguanides is reported, which are accessible by three alternative routes. Exemplary molecular structures of the ligand and an observed side product have been elucidated by X-ray diffraction ...
Helmar Görls (1403530), Maximilian Dehmel, Maximilian Dehmel (8441361), Helmar Görls, Robert Kretschmer, Valentin Vass, Lukas Prock (8441367), Valentin Vass (8441364), Robert Kretschmer (2154289), Lukas Prock   +9 more
core   +3 more sources

Mechanisms of NMDA Receptor Inhibition by Biguanide Compounds

Pharmaceuticals
N-methyl-D-aspartate (NMDA) receptors are inhibited by many medicinal drugs. The recent successful repurposing of NMDA receptor antagonists ketamine and dextromethorphan for the treatment of major depressive disorder further enhanced the interest in this
Arseniy S. Zhigulin, Anastasiya O. Novikova, Oleg I. Barygin   +2 more
doaj   +1 more source

Real‐Time Investigation of Interfacial Evolution in Electrochemical Energy Storage Systems via EQCM

Advanced Science, EarlyView.
Understanding the electrode/electrolyte interface (EEI) is crucial for supercapacitors and batteries. EQCM, by enabling real‐time monitoring of mass changes during charge–discharge cycles, has evolved into a vital method for analysis of EEI. It provides important insights into charge‐storage mechanisms, electrode structural evolution, ion‐transfer ...
Zixuan Wang, Situo Cheng, Guang Feng
wiley   +1 more source

The chemistry of biguanides: from synthetic routes to applications in organic chemistry [PDF]

, 2019
In this mini review, we focus on the chemistry and applications of biguanides. We summarize the type and preparation of biguanides, and their applications as superbases and ligands in catalysis.The accepted manuscript in pdf format is listed with the ...
Schmitzer, Andreea, Fortun, Solne
core   +2 more sources

Metformin: Focus on Melanoma

Frontiers in Endocrinology, 2018
Metformin is the most common biguanide used in the treatment of diabetes, with 120 million treated patients worldwide. Metformin decreases hyperglycemia without inducing hypoglycemia in diabetic patients and is very well tolerated.
Emilie Jaune, Emilie Jaune, Stéphane Rocchi, Stéphane Rocchi   +3 more
doaj   +1 more source

Trends in the utilization, expenditure and costs of noninsulin glucose‐lowering drugs in the Medicaid population: Steady increases in glucagon‐like peptide‐1 receptor agonist and sodium–glucose transporter‐2 inhibitor use, prices and expenditure

British Journal of Clinical Pharmacology, EarlyView.
Aims This study aimed to analyse changes in the utilization, expenditure and average cost of noninsulin glucose‐lowering drugs (GLDs) between 2008 and 2023. Methods This was a retrospective observational study of 2008–2023 data from the National Medicaid State Drug Utilization database.
Rawan O. Almadfaa
wiley   +1 more source

Target engagement of biguanides in colorectal carcinoma

Discover Chemistry
Colorectal cancer (CRC) continues to be the largest reason for disease-related illnesses and fatalities globally, emphasizing the critical necessity finding new along with affordable therapy approaches.
Poulami Patra, Rajat Subhra Dutta, Supriya Sahu   +2 more
doaj   +1 more source

Positional Isomer Engineering for Crystallization Kinetics Control in Wide‐Bandgap Perovskite Solar Cells

Carbon Energy, EarlyView.
Based on the ortho‐para configuration of the amino‐sulfonic acid group, 2,4‐diaminobenzenesulfonic acid (2,4‐DABSA) forms the strongest coordination with the perovskite precursor among its isomers, guiding a unique “fast nucleation followed by slow crystallization” kinetics.
Jun Chu, Chaoqi Liu, Xi Yang, Xiuhua Chen, Tao Zhu, Shaoyuan Li, Zhongqiu Tong, Huidong Ma, Jianjun Zhang, Jianghui Zheng, Wenhui Ma, Jessica Yajie Jiang   +11 more
wiley   +1 more source

Use of biguanides and the risk of colorectal cancer:a register-based cohort study [PDF]

, 2013
Observational studies have shown conflicting results on the potential protecting effect of biguanide use with the risk of colorectal neoplasms. In addition, the cellular mechanism can either support or oppose biguanides influence on colorectal carcinoma.
Henry, R.M.A., Dittrich, S.T., Vestergaard, Peter; id_orcid, Knapen, L.M., Dittrich, Suzanne T. A. M., Henry, Ronald M. A., Starup-Linde, J., Stolk, L.M., Linde, Jakob Starup, Neef, C.K., Knapen, Lotte M., Neef, Cees, Stolk, Leo M. L., de Vries, F., Vestergaard, P., de Vries, Frank, Bazelier, Marloes T., Bazelier, M.T., de Vries, F.; id_orcid   +18 more
core   +1 more source

Recent Developments in Diabetes Management: Exploring Receptors, Pathways, and Compounds

BIO Integration
Diabetes mellitus (DM) is a widespread metabolic disorder with profound effects on vital organs. Often referred to as a “systemic” or “multi-organ” disorder due to the impact on key organs, such as the kidneys, pancreas, eyes, and heart, DM is ...
Pallavi Pandey, Vikash Jakhmola, Supriyo Saha, Anand Gaurav   +3 more
doaj   +1 more source