Synthetic accesses to biguanide compounds
Beilstein Journal of Organic Chemistry, 2021 Biguanide is a unique chemical function, which has attracted much attention a century ago and is showing resurgent interest in recent years after a long period of dormancy.
Cyril Ronco, Rachid Benhida
exaly +2 more sources
The role of ATP synthase subunit e (ATP5I) in mediating the metabolic and antiproliferative effects of metformin in cancer cells [PDF]
eLifeHere, we identify the subunit e of F₁F₀-ATP synthase (ATP5I) as a target of metformin, a first-in-class antidiabetic biguanide. ATP5I maintains the stability of F₁F₀-ATP synthase dimers, which is crucial for shaping cristae morphology.
Guillaume Lefrançois +11 more
doaj +2 more sources
Repression of LKB1 by miR-17∼92 Sensitizes MYC-Dependent Lymphoma to Biguanide Treatment
Cell Reports Medicine, 2020 Summary: Cancer cells display metabolic plasticity to survive stresses in the tumor microenvironment. Cellular adaptation to energetic stress is coordinated in part by signaling through the liver kinase B1 (LKB1)-AMP-activated protein kinase (AMPK ...
Bridges Hannah R +2 more
exaly +3 more sources
Biguanide-functionalized peptide mimics effectively combat drug-resistant ESKAPE pathogens and meningitis [PDF]
Nature CommunicationsESKAPE pathogens-induced meningitis seriously threatens human health due to antimicrobial resistance and low permeability of blood-brain barrier (BBB).
Weinan Jiang +12 more
doaj +2 more sources
Comparative effectiveness of biguanides versus SGLT2 inhibitors on cardiovascular and cerebrovascular events, diabetic nephropathy, retinopathy, neuropathy, and treatment expenditures in patients with type 2 diabetes. [PDF]
PLoS ONEBackgroundSodium-glucose cotransporter-2 (SGLT2) inhibitors are increasingly recommended as first-line treatment for type 2 diabetes mellitus (T2DM), but head-to-head data comparing them with metformin, the canonical biguanide, remain sparse in Japan ...
Eiji Nakatani +15 more
doaj +2 more sources
A novel biguanide-derivative promotes NEDD4-mediated FGFR1 ubiquitination through BMI1 to overcome osimertinib resistance in NSCLC [PDF]
Cancer Biology & MedicineObjective: Osimertinib (OSI) therapy, a cornerstone in treating non-small cell lung cancer (NSCLC), has been severely limited by rapidly developing acquired resistance.
Mei Peng +9 more
doaj +2 more sources
Effects of Biguanide-PROTACs in Pancreatic Cancer Cells
MoleculesThis study focuses on the synthesis of Biguanide-PROTACs, formed by conjugating the biguanide motif with a spacer and a ligand for recognition subunits of two E3 ubiquitin ligases.
Gerardo Ferbeyre +2 more
exaly +3 more sources
Gaining Insight into Mitochondrial Targeting: AUTAC-Biguanide as an Anticancer Agent
MoleculesAUTAC-Biguanide is a hybrid compound designed to target mitochondria, inducing their degradation by mitophagy. This study unveils the potential of biguanides as cancer cell-targeting agents, emphasizing AUTAC-Biguanide’s superior antiproliferative ...
Gerardo Ferbeyre +2 more
exaly +3 more sources
Contact allergy to polyhexamethylene biguanide (polyaminopropyl biguanide) [PDF]
Contact Dermatitis, 2020 AbstractBackgroundPolyaminopropyl biguanide (INCI name) and polyhexamethylene biguanide (PHMB) are polymeric biguanides. PHMB is a broad‐spectrum antimicrobial substance used as a preservative in many products. Due to our limited knowledge on PHMB contact allergy frequency and the fact that cases of allergic contact dermatitis to PHMB might be missed ...
Thanisorn Sukakul +9 more
openaire +4 more sources
Molecules, 2021 Among the known biguanide drugs, proguanil has the best antiproliferative activity. In contrast, newly synthesized biguanide derivatives containing fluorine atoms have excellent biological activity, among which trifluoromethoxy compounds show the ...
Simeng Xu +6 more
doaj +1 more source