Repression of LKB1 by miR-17∼92 Sensitizes MYC-Dependent Lymphoma to Biguanide Treatment
Cell Reports Medicine, 2020 Summary: Cancer cells display metabolic plasticity to survive stresses in the tumor microenvironment. Cellular adaptation to energetic stress is coordinated in part by signaling through the liver kinase B1 (LKB1)-AMP-activated protein kinase (AMPK ...
Said Izreig +2 more
exaly +3 more sources
Biguanide-functionalized peptide mimics effectively combat drug-resistant ESKAPE pathogens and meningitis [PDF]
Nature CommunicationsESKAPE pathogens-induced meningitis seriously threatens human health due to antimicrobial resistance and low permeability of blood-brain barrier (BBB).
Weinan Jiang +12 more
doaj +2 more sources
A novel biguanide-derivative promotes NEDD4-mediated FGFR1 ubiquitination through BMI1 to overcome osimertinib resistance in NSCLC [PDF]
Cancer Biology & MedicineObjective: Osimertinib (OSI) therapy, a cornerstone in treating non-small cell lung cancer (NSCLC), has been severely limited by rapidly developing acquired resistance.
Mei Peng +9 more
doaj +2 more sources
Comparative effectiveness of biguanides versus SGLT2 inhibitors on cardiovascular and cerebrovascular events, diabetic nephropathy, retinopathy, neuropathy, and treatment expenditures in patients with type 2 diabetes. [PDF]
PLoS ONEBackgroundSodium-glucose cotransporter-2 (SGLT2) inhibitors are increasingly recommended as first-line treatment for type 2 diabetes mellitus (T2DM), but head-to-head data comparing them with metformin, the canonical biguanide, remain sparse in Japan ...
Eiji Nakatani +15 more
doaj +2 more sources
Gaining Insight into Mitochondrial Targeting: AUTAC-Biguanide as an Anticancer Agent
MoleculesAUTAC-Biguanide is a hybrid compound designed to target mitochondria, inducing their degradation by mitophagy. This study unveils the potential of biguanides as cancer cell-targeting agents, emphasizing AUTAC-Biguanide’s superior antiproliferative ...
Veronique Bourdeau +2 more
exaly +3 more sources
Contact allergy to polyhexamethylene biguanide (polyaminopropyl biguanide) [PDF]
Contact Dermatitis, 2020 AbstractBackgroundPolyaminopropyl biguanide (INCI name) and polyhexamethylene biguanide (PHMB) are polymeric biguanides. PHMB is a broad‐spectrum antimicrobial substance used as a preservative in many products. Due to our limited knowledge on PHMB contact allergy frequency and the fact that cases of allergic contact dermatitis to PHMB might be missed ...
Thanisorn Sukakul +9 more
openaire +4 more sources
Molecules, 2021 Among the known biguanide drugs, proguanil has the best antiproliferative activity. In contrast, newly synthesized biguanide derivatives containing fluorine atoms have excellent biological activity, among which trifluoromethoxy compounds show the ...
Simeng Xu +6 more
doaj +1 more source
Frontiers in Chemistry, 2022 The challenge of infectious diseases remains a critical concern to the global public health. Recently, it is common to encounter touch-screen electronic devices everywhere to access services.
Hailemichael Ayalew +6 more
doaj +1 more source
Mild Biamidine-Transfer Conditions for the Synthesis of Aliphatic Biguanides
SynOpen, 2021 This study focuses on the development of new synthetic pathways to monosubstituted biguanides from amines. An exhaustive comparison of the conditions and reagents used for biamidine transfer was performed.
Rostyslav Bardovskyi +3 more
doaj +1 more source
Frontiers in Cellular and Infection Microbiology, 2023 Antimicrobial resistance is a critical public health issue that requires a thorough understanding of the factors that influence the selection and spread of antibiotic-resistant bacteria.
Raphaël Charron +9 more
doaj +1 more source