Bactericidal Effect and Mechanism of Polyhexamethylene Biguanide (PHMB) on Pathogenic Bacteria in Marine Aquaculture [PDF]
BiologyGuanidine disinfectants are cationic polymers recognized for their effective sterilization properties and their ability to prevent bacterial resistance.
Lanting Wu +9 more
doaj +4 more sources
The dltC gene contributes to polyhexamethylene biguanide resistance in Staphylococcus aureus [PDF]
Frontiers in MicrobiologyAs the efficacy of conventional antibiotics continues to decline due to antibiotic resistance, there is an urgent need for alternative antimicrobial strategies.
Chenyang Guo +10 more
doaj +2 more sources
Polihexanide (PHMB) 0.08% versus currently used treatments for Acanthamoeba keratitis: indirect treatment comparisons [PDF]
BMJ Open OphthalmologyBackground/aims Acanthamoeba keratitis is a rare, severe corneal infection. Until the recent approval of polihexanide (PHMB) 0.08% by the European Medicines Agency, there were no licensed medical therapies and current treatments relied on off-label or ...
Vincenzo Papa +7 more
doaj +2 more sources
3D-Printed PLDLA–TMC/PEG 400 Vascular Scaffolds with a Poly(hexamethylene Biguanide) Antibacterial Coating [PDF]
PharmaceuticsBackground: Synthetic vascular scaffolds often exhibit limited mechanical performance and low hydrophilicity, which compromise early vascular integration and increase susceptibility to bacterial colonization.
Monique M. Munhoz +8 more
doaj +2 more sources
A PHMB-Functionalized Fully Absorbable Synthetic Matrix as a Novel Alternative to Biologics: Balancing Antibacterial Efficacy, Tissue Repair, and Safety [PDF]
BioengineeringEffective management of acute, complex, and chronic wounds requires constructs that simultaneously support tissue repair and provide sustained infection control.
Sean Chen +4 more
doaj +2 more sources
Polyhexamethylene Biguanide Nanoparticles Inhibit Biofilm Formation by Mastitis-Causing Staphylococcus aureus [PDF]
Veterinary SciencesStaphylococcus aureus is a mastitis pathogen that compromises cow health and causes significant economic losses in the dairy industry. High antimicrobial resistance and biofilm formation by S. aureus limit the efficacy of conventional treatments.
Renata de Freitas Leite +9 more
doaj +2 more sources
Membranes, 2022 Composite bacterial cellulose (BC) based hydrogel with alginate (A) or pectin (P) or alginate and pectin was fabricated via a physical crosslinking technique using calcium chloride (CaCl2) solution and incorporated with polyhexamethylene biguanide (PHMB)
Baramee Chanabodeechalermrung +6 more
doaj +1 more source
JDS Communications, 2021 Postmilking teat disinfection is one of the main measures used to prevent mastitis caused by contagious pathogens, such as Staphylococcus aureus. The present study evaluated the antimicrobial activity of polyhexamethylene biguanide (PHMB) and PHMB ...
R.F. Leite +7 more
doaj +1 more source
Effect of combined therapy polyhexamethylene biguanide and Coriolus-MRL on human papilloma virus (HPV) cervical and vulvar-related lesions [PDF]
International Journal of Medical Device and Adjuvant Treatments, 2020 OBJECTIVE: Human papillomavirus (HPV) persistent infections of genital tract are strongly related to the development of genital warts and cellular transformation.
D. Gincheva, V. Gincheva, E. Konova
doaj +1 more source
Stability of an ophthalmic formulation of polyhexamethylene biguanide in gamma-sterilized and ethylene oxide sterilized low density polyethylene multidose eyedroppers [PDF]
PeerJ, 2018 Background Polyhexamethylene biguanide (PHMB) eye drops are a frequently used medication to treat Acanthamoeba keratitis. In the absence of marketed PHMB eye drops, pharmacy-compounding units are needed to prepare this much needed treatment, but the lack
Yassine Bouattour +4 more
doaj +2 more sources