BiologyGuanidine disinfectants are cationic polymers recognized for their effective sterilization properties and their ability to prevent bacterial resistance.
Cuiping Ma, Meijie Liao, Xiaojun Rong
exaly +6 more sources
Study of Epigenetic Properties of Poly(HexaMethylene Biguanide) Hydrochloride (PHMB) [PDF]
International Journal of Environmental Research and Public Health, 2014 Poly(HexaMethylene Biguanide) hydrochloride (PHMB) CAS No. [32289-58-0] is a particularly effective member of the biguanides antiseptic chemical group, and has been in use since the early fifties in numerous applications. It has been proposed that PHMB be classified as a category 3 carcinogen although PHMB is not genotoxic.
Daniel Cros +2 more
exaly +7 more sources
Pathogen- and Host-Directed Antileishmanial Effects Mediated by Polyhexanide (PHMB). [PDF]
PLoS Neglected Tropical Diseases, 2015 BACKGROUND:Cutaneous leishmaniasis (CL) is a neglected tropical disease caused by protozoan parasites of the genus Leishmania. CL causes enormous suffering in many countries worldwide. There is no licensed vaccine against CL, and the chemotherapy options
Rebuma Firdessa +11 more
doaj +8 more sources
Polyhexanide (PHMB) – properties and applications in medicine [PDF]
European Journal of Biological Research, 2020 Polyhexamethylene biguanide (PHMB) is one of the many antiseptics available in the medicine. It stands out from the others with its numerous advantages.
Patrycja Szkołuda, Tomasz M. Karpiński
doaj +4 more sources
Polihexanide (PHMB) 0.08% versus currently used treatments for Acanthamoeba keratitis: indirect treatment comparisons [PDF]
BMJ Open OphthalmologyBackground/aims Acanthamoeba keratitis is a rare, severe corneal infection. Until the recent approval of polihexanide (PHMB) 0.08% by the European Medicines Agency, there were no licensed medical therapies and current treatments relied on off-label or ...
Vincenzo Papa +7 more
doaj +4 more sources
PHMB: Utilización del apósito de espuma antimicrobiana (AMD) KendallTM (PHMB 0,5%) en el tratamiento de las heridas crónicas [PDF]
Gerokomos, 2010 Abordamos la parte más problemática del tratamiento de las heridas crónicas o agudas, de acuerdo con los profesionales especializados es la infección de la herida.
John Timmons, Kathy Leak
doaj +3 more sources
The dltC gene contributes to polyhexamethylene biguanide resistance in Staphylococcus aureus [PDF]
Frontiers in MicrobiologyAs the efficacy of conventional antibiotics continues to decline due to antibiotic resistance, there is an urgent need for alternative antimicrobial strategies.
Chenyang Guo +10 more
doaj +2 more sources
Monotherapy with PHMB 0.08% as “Switch Treatment” in Complex Cases of Acanthamoeba Keratitis: A Report of Two Cases [PDF]
Case Reports in OphthalmologyIntroduction: The aim of the study was to describe the favorable clinical outcomes of 2 patients with acanthamoeba keratitis (AK) following penetrating keratoplasty (PK), successfully managed with polyhexamethylene biguanide (PHMB) 0.08 ...
Eleftherios Chatzimichail +4 more
doaj +2 more sources
A PHMB-Functionalized Fully Absorbable Synthetic Matrix as a Novel Alternative to Biologics: Balancing Antibacterial Efficacy, Tissue Repair, and Safety [PDF]
BioengineeringEffective management of acute, complex, and chronic wounds requires constructs that simultaneously support tissue repair and provide sustained infection control.
Sean Chen +4 more
doaj +2 more sources
3D-Printed PLDLA–TMC/PEG 400 Vascular Scaffolds with a Poly(hexamethylene Biguanide) Antibacterial Coating [PDF]
PharmaceuticsBackground: Synthetic vascular scaffolds often exhibit limited mechanical performance and low hydrophilicity, which compromise early vascular integration and increase susceptibility to bacterial colonization.
Monique M. Munhoz +8 more
doaj +2 more sources