Results 11 to 20 of about 1,778 (169)

Pathogen- and Host-Directed Antileishmanial Effects Mediated by Polyhexanide (PHMB). [PDF]

PLoS Neglected Tropical Diseases, 2015
BACKGROUND:Cutaneous leishmaniasis (CL) is a neglected tropical disease caused by protozoan parasites of the genus Leishmania. CL causes enormous suffering in many countries worldwide. There is no licensed vaccine against CL, and the chemotherapy options
Rebuma Firdessa, Liam Good, Maria Cecilia Amstalden, Kantaraja Chindera, Nor Fadhilah Kamaruzzaman, Martina Schultheis, Bianca Röger, Nina Hecht, Tobias A Oelschlaeger, Lorenz Meinel, Tessa Lühmann, Heidrun Moll   +11 more
doaj   +6 more sources

Polyhexanide (PHMB) – properties and applications in medicine

European Journal of Biological Research, 2020
Polyhexamethylene biguanide (PHMB) is one of the many antiseptics available in the medicine. It stands out from the others with its numerous advantages.
Patrycja Szkołuda, Tomasz M. Karpiński
doaj   +3 more sources

Fungal cell barriers and organelles are disrupted by polyhexamethylene biguanide (PHMB)

Scientific Reports, 2023
The similarities between fungal and mammalian cells pose inherent challenges for the development of treatments for fungal infections, due to drug crossover recognition of host drug targets by antifungal agents.
Winnie Ntow-Boahene, Isabelle Papandronicou, Josephous Miculob, Liam Good   +3 more
doaj   +3 more sources

PHMB: Utilización del apósito de espuma antimicrobiana (AMD) KendallTM (PHMB 0,5%) en el tratamiento de las heridas crónicas [PDF]

Gerokomos, 2010
Abordamos la parte más problemática del tratamiento de las heridas crónicas o agudas, de acuerdo con los profesionales especializados es la infección de la herida.
John Timmons, Kathy Leak
doaj   +3 more sources

The Orphan Drug for Acanthamoeba Keratitis (ODAK) Trial: PHMB 0.08% (Polihexanide) and Placebo versus PHMB 0.02% and Propamidine 0.1. [PDF]

Ophthalmology, 2023
To compare topical PHMB (polihexanide) 0.02% (0.2 mg/ml)+ propamidine 0.1% (1 mg/ml) with PHMB 0.08% (0.8 mg/ml)+ placebo (PHMB 0.08%) for Acanthamoeba keratitis (AK) treatment.Prospective, randomized, double-masked, active-controlled, multicenter phase 3 study (ClinicalTrials.gov identifier, NCT03274895).One hundred thirty-five patients treated at 6 ...
Dart, John K.G., Papa, Vincenzo, Rama, Paolo, Knutsson, Karl Anders, Ahmad, Saj, Hau, Scott, Sanchez, Sara, Franch, Antonella, Birattari, Federica, Leon, Pia, Fasolo, Adriano, Kominek, Ewa Mrukwa, Jadczyk-Sorek, Katarzyna, Carley, Fiona, Hossain, Parwez, Minassian, Darwin C.   +15 more
openaire   +5 more sources

From Plastic Waste to Pharmaceutical Precursors: PET Upcycling Through Ruthenium Catalyzed Semi-Hydrogenation. [PDF]

Angew Chem Int Ed Engl
We present a new catalytic process that converts real‐life PET waste into ethyl 4‐hydroxymethylbenzoate (EHMB), which serves as a valuable intermediate for the synthesis of pharmaceuticals, an insecticide, and a novel polyester. Abstract We report here the upcycling of PET (polyethylene terephthalate) waste via semihydrogenation to make ethyl 4 ...
Kulyabin PS, Luk J, Uslamin EA, Kolganov AA, Saini G, Marcial-Hernandez R, Pancholi K, Kühne B, Dauth A, McKay AP, Cordes DB, Pidko EA, Kumar A.   +12 more
europepmc   +3 more sources

Evaluation of Polyhexamethylene Biguanide (PHMB) as a Disinfectant for Adenovirus [PDF]

JAMA Ophthalmology, 2013
Swimming pools can be a vector for transmission of adenovirus ocular infections. Polyhexamethylene biguanide (PHMB) is a disinfectant used in swimming pools and hot tubs.To determine whether PHMB is an effective disinfectant against ocular adenovirus serotypes at a concentration used to disinfect swimming pools and hot tubs.In vitro laboratory study ...
Eric G, Romanowski, Kathleen A, Yates, Katherine E, O'Connor, Francis S, Mah, Robert M Q, Shanks, Regis P, Kowalski   +5 more
openaire   +2 more sources

In Vitro and In Vivo Comparison of a Novel Antimicrobial Wound Hydrogel With Commercial Wound Treatments: Antimicrobial, Antibiofilm and Biocompatibility Assessment. [PDF]

Int Wound J
ABSTRACT Antimicrobial resistance (AMR) and biofilm formation significantly hinder chronic wound management, necessitating safer and more effective therapeutic options. This study evaluates the antimicrobial, antibiofilm, cytocompatibility and anti‐inflammatory properties of a novel antimicrobial hydrogel Formulation (#1) compared with commercially ...
Moradi M, Pormohammad A, Luong C, Turner RJ.   +3 more
europepmc   +2 more sources

Polyvinyl Alcohol/Chitosan/Polyhexamethylene Biguanide Phase Separation System: A Potential Topical Antibacterial Formulation with Enhanced Antimicrobial Effect

Molecules, 2020
An aqueous polyvinyl alcohol (PVA)/chitosan (CHT)/polyhexamethylene biguanide (PHMB) blends (PVA/CHT/PHMB blends) has been developed as a potential low dose topical antibacterial formulation with enhanced antimicrobial effect.
Yunzhou Ni, Zhixiang Qian, Yu Yin, Weien Yuan, Fei Wu, Tuo Jin   +5 more
doaj   +1 more source

Safety assessment of Polyhexamethylene biguanide [PDF]

International Journal of Medical Device and Adjuvant Treatments, 2019
OBJECTIVE: The use of antiseptics in the treatment of genital infections has become a systematic alternative to antibiotics. Their use has been also supported for the treatment of virus-induced genital infections.
B. Orrù, P. Lista, M. Bertelli, V. Unfer   +3 more
doaj   +1 more source