Pathogen- and Host-Directed Antileishmanial Effects Mediated by Polyhexanide (PHMB). [PDF]
PLoS Neglected Tropical Diseases, 2015 BACKGROUND:Cutaneous leishmaniasis (CL) is a neglected tropical disease caused by protozoan parasites of the genus Leishmania. CL causes enormous suffering in many countries worldwide. There is no licensed vaccine against CL, and the chemotherapy options
Rebuma Firdessa +11 more
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Polyhexanide (PHMB) – properties and applications in medicine
European Journal of Biological Research, 2020 Polyhexamethylene biguanide (PHMB) is one of the many antiseptics available in the medicine. It stands out from the others with its numerous advantages.
Patrycja Szkołuda, Tomasz M. Karpiński
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PHMB: Utilización del apósito de espuma antimicrobiana (AMD) KendallTM (PHMB 0,5%) en el tratamiento de las heridas crónicas [PDF]
Gerokomos, 2010 Abordamos la parte más problemática del tratamiento de las heridas crónicas o agudas, de acuerdo con los profesionales especializados es la infección de la herida.
John Timmons, Kathy Leak
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The Orphan Drug for Acanthamoeba Keratitis (ODAK) Trial: PHMB 0.08% (Polihexanide) and Placebo versus PHMB 0.02% and Propamidine 0.1. [PDF]
Ophthalmology, 2023 To compare topical PHMB (polihexanide) 0.02% (0.2 mg/ml)+ propamidine 0.1% (1 mg/ml) with PHMB 0.08% (0.8 mg/ml)+ placebo (PHMB 0.08%) for Acanthamoeba keratitis (AK) treatment.Prospective, randomized, double-masked, active-controlled, multicenter phase 3 study (ClinicalTrials.gov identifier, NCT03274895).One hundred thirty-five patients treated at 6 ...
Dart, John K.G. +15 more
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Evaluation of Polyhexamethylene Biguanide (PHMB) as a Disinfectant for Adenovirus [PDF]
JAMA Ophthalmology, 2013 Swimming pools can be a vector for transmission of adenovirus ocular infections. Polyhexamethylene biguanide (PHMB) is a disinfectant used in swimming pools and hot tubs.To determine whether PHMB is an effective disinfectant against ocular adenovirus serotypes at a concentration used to disinfect swimming pools and hot tubs.In vitro laboratory study ...
Eric G, Romanowski +5 more
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From Plastic Waste to Pharmaceutical Precursors: PET Upcycling Through Ruthenium Catalyzed Semi-Hydrogenation. [PDF]
Angew Chem Int Ed EnglWe present a new catalytic process that converts real‐life PET waste into ethyl 4‐hydroxymethylbenzoate (EHMB), which serves as a valuable intermediate for the synthesis of pharmaceuticals, an insecticide, and a novel polyester. Abstract We report here the upcycling of PET (polyethylene terephthalate) waste via semihydrogenation to make ethyl 4 ...
Kulyabin PS +12 more
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In Vitro and In Vivo Comparison of a Novel Antimicrobial Wound Hydrogel With Commercial Wound Treatments: Antimicrobial, Antibiofilm and Biocompatibility Assessment. [PDF]
Int Wound JABSTRACT Antimicrobial resistance (AMR) and biofilm formation significantly hinder chronic wound management, necessitating safer and more effective therapeutic options. This study evaluates the antimicrobial, antibiofilm, cytocompatibility and anti‐inflammatory properties of a novel antimicrobial hydrogel Formulation (#1) compared with commercially ...
Moradi M +3 more
europepmc +2 more sources
Stability of an ophthalmic formulation of polyhexamethylene biguanide in gamma-sterilized and ethylene oxide sterilized low density polyethylene multidose eyedroppers [PDF]
PeerJ, 2018 Background Polyhexamethylene biguanide (PHMB) eye drops are a frequently used medication to treat Acanthamoeba keratitis. In the absence of marketed PHMB eye drops, pharmacy-compounding units are needed to prepare this much needed treatment, but the lack
Yassine Bouattour +4 more
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Molecules, 2020 An aqueous polyvinyl alcohol (PVA)/chitosan (CHT)/polyhexamethylene biguanide (PHMB) blends (PVA/CHT/PHMB blends) has been developed as a potential low dose topical antibacterial formulation with enhanced antimicrobial effect.
Yunzhou Ni +5 more
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Safety assessment of Polyhexamethylene biguanide [PDF]
International Journal of Medical Device and Adjuvant Treatments, 2019 OBJECTIVE: The use of antiseptics in the treatment of genital infections has become a systematic alternative to antibiotics. Their use has been also supported for the treatment of virus-induced genital infections.
B. Orrù +3 more
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