The Orphan Drug for Acanthamoeba Keratitis (ODAK) Trial: PHMB 0.08% (Polihexanide) and Placebo versus PHMB 0.02% and Propamidine 0.1. [PDF]
Ophthalmology, 2023 To compare topical PHMB (polihexanide) 0.02% (0.2 mg/ml)+ propamidine 0.1% (1 mg/ml) with PHMB 0.08% (0.8 mg/ml)+ placebo (PHMB 0.08%) for Acanthamoeba keratitis (AK) treatment.Prospective, randomized, double-masked, active-controlled, multicenter phase 3 study (ClinicalTrials.gov identifier, NCT03274895).One hundred thirty-five patients treated at 6 ...
Dart, John K.G. +15 more
core +6 more sources
The Activity of PHMB and Other Guanidino Containing Compounds against Acanthamoeba and Other Ocular Pathogens [PDF]
Microorganisms, 2022 In recent years, a rise in the number of contact lens users in the UK and worldwide coincided with an increased incidence of microbial keratitis. The aim of this study was to investigate the antimicrobial activities of polyhexamethylene guanidine (PHMG),
Dharanga Ratnayake +3 more
doaj +2 more sources
The Effects of Polyhexamethylene Biguanide (PHMB) and TLR Agonists Alone or as Polyplex Nanoparticles against Leishmania infantum Promastigotes and Amastigotes [PDF]
Veterinary Sciences, 2020 Dogs are the main reservoir for Leishmania infantum, manifesting from a subclinical to a fatal disease. Limited treatments are available, although new antiparasitics and immunomodulators are pursued.
Pamela Martínez-Orellana +3 more
doaj +2 more sources
The antimicrobial polymer PHMB enters cells and selectively condenses bacterial chromosomes [PDF]
Scientific Reports, 2016 AbstractTo combat infection and antimicrobial resistance, it is helpful to elucidate drug mechanism(s) of action. Here we examined how the widely used antimicrobial polyhexamethylene biguanide (PHMB) kills bacteria selectively over host cells. Contrary to the accepted model of microbial membrane disruption by PHMB, we observed cell entry into a range ...
Chindera K +10 more
openaire +7 more sources
Polyhexamethylene Biguanide Nanoparticles Inhibit Biofilm Formation by Mastitis-Causing Staphylococcus aureus [PDF]
Veterinary SciencesStaphylococcus aureus is a mastitis pathogen that compromises cow health and causes significant economic losses in the dairy industry. High antimicrobial resistance and biofilm formation by S. aureus limit the efficacy of conventional treatments.
Renata de Freitas Leite +9 more
doaj +2 more sources
PHMB como desinfectante e anti-séptico [PDF]
, 2013 Esta dissertação pretende dar a conhecer as propriedades anti-sépticas e desinfectantes da Polihexametileno biguanida (PHMB). Para tal foi efectuada uma revisão bibliográfica, denotando-se um ascendente no desenvolvimento deste tipo de compostos, resultado de uma forte necessidade de novas formulações no mercado.
Afonso, Francisco Ribeiro
openaire +2 more sources
JDS Communications, 2021 Postmilking teat disinfection is one of the main measures used to prevent mastitis caused by contagious pathogens, such as Staphylococcus aureus. The present study evaluated the antimicrobial activity of polyhexamethylene biguanide (PHMB) and PHMB ...
R.F. Leite +7 more
doaj +1 more source
Membranes, 2022 Composite bacterial cellulose (BC) based hydrogel with alginate (A) or pectin (P) or alginate and pectin was fabricated via a physical crosslinking technique using calcium chloride (CaCl2) solution and incorporated with polyhexamethylene biguanide (PHMB)
Baramee Chanabodeechalermrung +6 more
doaj +1 more source
Effect of combined therapy polyhexamethylene biguanide and Coriolus-MRL on human papilloma virus (HPV) cervical and vulvar-related lesions [PDF]
International Journal of Medical Device and Adjuvant Treatments, 2020 OBJECTIVE: Human papillomavirus (HPV) persistent infections of genital tract are strongly related to the development of genital warts and cellular transformation.
D. Gincheva, V. Gincheva, E. Konova
doaj +1 more source
Evaluation of Polyhexamethylene Biguanide (PHMB) as a Disinfectant for Adenovirus [PDF]
JAMA Ophthalmology, 2013 Swimming pools can be a vector for transmission of adenovirus ocular infections. Polyhexamethylene biguanide (PHMB) is a disinfectant used in swimming pools and hot tubs.To determine whether PHMB is an effective disinfectant against ocular adenovirus serotypes at a concentration used to disinfect swimming pools and hot tubs.In vitro laboratory study ...
Eric G, Romanowski +5 more
openaire +2 more sources