Results 11 to 20 of about 4,114 (213)

Pathogen- and Host-Directed Antileishmanial Effects Mediated by Polyhexanide (PHMB). [PDF]

PLoS Neglected Tropical Diseases, 2015
BACKGROUND:Cutaneous leishmaniasis (CL) is a neglected tropical disease caused by protozoan parasites of the genus Leishmania. CL causes enormous suffering in many countries worldwide. There is no licensed vaccine against CL, and the chemotherapy options
Rebuma Firdessa, Liam Good, Maria Cecilia Amstalden, Kantaraja Chindera, Nor Fadhilah Kamaruzzaman, Martina Schultheis, Bianca Röger, Nina Hecht, Tobias A Oelschlaeger, Lorenz Meinel, Tessa Lühmann, Heidrun Moll   +11 more
doaj   +11 more sources

Bactericidal Effect and Mechanism of Polyhexamethylene Biguanide (PHMB) on Pathogenic Bacteria in Marine Aquaculture. [PDF]

Biology (Basel)
Guanidine disinfectants are cationic polymers recognized for their effective sterilization properties and their ability to prevent bacterial resistance.
Wu L, Wang C, Wang Y, Yu Y, Zhang Z, Ma C, Rong X, Chen L, Liao M, Yang Y.   +9 more
europepmc   +4 more sources

The dltC gene contributes to polyhexamethylene biguanide resistance in <i>Staphylococcus aureus</i>. [PDF]

Front Microbiol
As the efficacy of conventional antibiotics continues to decline due to antibiotic resistance, there is an urgent need for alternative antimicrobial strategies.
Guo C, Wang C, Chen Q, Zheng SH, Zhang F, Yan J, Long HB, Luo J, Xuan X, Wang P, Zheng H.   +10 more
europepmc   +2 more sources

Polihexanide (PHMB) 0.08% versus currently used treatments for <i>Acanthamoeba</i> keratitis: indirect treatment comparisons. [PDF]

BMJ Open Ophthalmol
Background/aims Acanthamoeba keratitis is a rare, severe corneal infection. Until the recent approval of polihexanide (PHMB) 0.08% by the European Medicines Agency, there were no licensed medical therapies and current treatments relied on off-label or ...
Papa V, Galeone C, De Francesco M, Bodicoat DH, Alves R, Spaepen E, Dart JKG, Arteaga C.   +7 more
europepmc   +2 more sources

The antimicrobial polymer PHMB enters cells and selectively condenses bacterial chromosomes [PDF]

Scientific Reports, 2016
To combat infection and antimicrobial resistance, it is helpful to elucidate drug mechanism(s) of action. Here we examined how the widely used antimicrobial polyhexamethylene biguanide (PHMB) kills bacteria selectively over host cells.
A Gentile, B Spellberg, CE Barry, CR Messick, DJ Dwyer, EE Creppy, EF Palermo, FW O’Grady, G Muller, G Muller, G Rusciano, GS Gordon, J Portugal, JD McCool, JM Boberek, JP Armitage, L Good, LP O’Malley, M Mondhe, MA Kohanski, MJ Allen, MJ Allen, MJ Allen, N Nekhotiaeva, Nakashima, P Broxton, P Broxton, P Broxton, P Erbacher, P Gilbert, R de Vries, R Dryselius, R Firdessa, R Spurio, RF Murphy, S Amoils, S Goh, S Wessels, T Ikeda, T Ikeda, T Kornberg, VB Teif   +41 more
core   +8 more sources

3D-Printed PLDLA-TMC/PEG 400 Vascular Scaffolds with a Poly(hexamethylene Biguanide) Antibacterial Coating. [PDF]

Pharmaceutics
Background: Synthetic vascular scaffolds often exhibit limited mechanical performance and low hydrophilicity, which compromise early vascular integration and increase susceptibility to bacterial colonization.
Munhoz MM, Pedrini F, de Barros CT, Dias ME, Fanelli C, Noronha IL, Komatsu D, Duek EAR, Hausen MA.   +8 more
europepmc   +2 more sources

A PHMB-Functionalized Fully Absorbable Synthetic Matrix as a Novel Alternative to Biologics: Balancing Antibacterial Efficacy, Tissue Repair, and Safety. [PDF]

Bioengineering (Basel)
Effective management of acute, complex, and chronic wounds requires constructs that simultaneously support tissue repair and provide sustained infection control.
Chen S, Bibbo C, Starinski J, Xu X, Wang C.   +4 more
europepmc   +2 more sources

Polyhexamethylene Biguanide Nanoparticles Inhibit Biofilm Formation by Mastitis-Causing <i>Staphylococcus aureus</i>. [PDF]

Vet Sci
Staphylococcus aureus is a mastitis pathogen that compromises cow health and causes significant economic losses in the dairy industry. High antimicrobial resistance and biofilm formation by S. aureus limit the efficacy of conventional treatments.
Leite RF, Garcia BLN, Barbosa KDS, Mitsunaga TM, Fidelis CE, Dias BJM, Miranda RR, Zucolotto V, Good L, Santos MVD.   +9 more
europepmc   +2 more sources

PHMB: Utilización del apósito de espuma antimicrobiana (AMD) KendallTM (PHMB 0,5%) en el tratamiento de las heridas crónicas [PDF]

Gerokomos, 2010
Abordamos la parte más problemática del tratamiento de las heridas crónicas o agudas, de acuerdo con los profesionales especializados es la infección de la herida.
John Timmons, Kathy Leak
doaj   +3 more sources

From Plastic Waste to Pharmaceutical Precursors: PET Upcycling Through Ruthenium Catalyzed Semi-Hydrogenation. [PDF]

Angew Chem Int Ed Engl
We present a new catalytic process that converts real‐life PET waste into ethyl 4‐hydroxymethylbenzoate (EHMB), which serves as a valuable intermediate for the synthesis of pharmaceuticals, an insecticide, and a novel polyester. Abstract We report here the upcycling of PET (polyethylene terephthalate) waste via semihydrogenation to make ethyl 4 ...
Kulyabin PS, Luk J, Uslamin EA, Kolganov AA, Saini G, Marcial-Hernandez R, Pancholi K, Kühne B, Dauth A, McKay AP, Cordes DB, Pidko EA, Kumar A.   +12 more
europepmc   +3 more sources