Results 11 to 20 of about 20,567 (248)

Alkyl Chain Length Governs Structure, Conformation and Antimicrobial Activity in Poly(alkylene biguanide). [PDF]

Polymers (Basel)
Al-Ani E, Doudin K, McBain AJ, Ahmad Z, Freeman S.   +4 more
europepmc   +3 more sources

Contact allergy to polyhexamethylene biguanide (polyaminopropyl biguanide) [PDF]

Contact Dermatitis, 2020
AbstractBackgroundPolyaminopropyl biguanide (INCI name) and polyhexamethylene biguanide (PHMB) are polymeric biguanides. PHMB is a broad‐spectrum antimicrobial substance used as a preservative in many products. Due to our limited knowledge on PHMB contact allergy frequency and the fact that cases of allergic contact dermatitis to PHMB might be missed ...
Thanisorn Sukakul, Jakob Dahlin, Ann Pontén, Annarita Antelmi, Magnus Bruze, Nils Hamnerius, Inese Hauksson, Marléne Isaksson, Tina Lejding, Cecilia Svedman   +9 more
openaire   +4 more sources

Biguanide-functionalized peptide mimics effectively combat drug-resistant ESKAPE pathogens and meningitis. [PDF]

Nat Commun
ESKAPE pathogens-induced meningitis seriously threatens human health due to antimicrobial resistance and low permeability of blood-brain barrier (BBB).
Jiang W, Zhou M, Chen K, Xiao X, Shi J, Zhang H, Xie J, Chen S, Chen M, Cong Z, Liu L, Wu Y, Liu R.   +12 more
europepmc   +2 more sources

ARYL BIGUANIDES [PDF]

Chemical & Engineering News Archive, 1949
openaire   +2 more sources

Synthesis, Anti-Proliferative Evaluation and Mechanism of 4-Trifluoro Methoxy Proguanil Derivatives with Various Carbon Chain Length

Molecules, 2021
Among the known biguanide drugs, proguanil has the best antiproliferative activity. In contrast, newly synthesized biguanide derivatives containing fluorine atoms have excellent biological activity, among which trifluoromethoxy compounds show the ...
Simeng Xu, Yufang Cao, Yu Luo, Di Xiao, Wei Wang, Zhiren Wang, Xiaoping Yang   +6 more
doaj   +1 more source

The role of ATP synthase subunit e (ATP5I) in mediating the metabolic and antiproliferative effects of metformin in cancer cells. [PDF]

Elife
Here, we identify the subunit e of F₁F₀-ATP synthase (ATP5I) as a target of metformin, a first-in-class antidiabetic biguanide. ATP5I maintains the stability of F₁F₀-ATP synthase dimers, which is crucial for shaping cristae morphology.
Lefrançois G, Lavallée E, Rowell MC, Bourdeau V, Mohebali F, Bertomeu T, Duman AM, Nikolova M, Tyers M, Gravel SP, Schmitzer AR, Ferbeyre G.   +11 more
europepmc   +2 more sources

Biguanide- and Oligo(Ethylene Glycol)-Functionalized Poly(3,4-Ethylenedioxythiophene): Electroactive, Antimicrobial, and Antifouling Surface Coatings

Frontiers in Chemistry, 2022
The challenge of infectious diseases remains a critical concern to the global public health. Recently, it is common to encounter touch-screen electronic devices everywhere to access services.
Hailemichael Ayalew, Syed Atif Ali, Syed Atif Ali, Syed Atif Ali, Jia-Wei She, Hsiao-hua Yu, Hsiao-hua Yu   +6 more
doaj   +1 more source

Mild Biamidine-Transfer Conditions for the Synthesis of Aliphatic Biguanides

SynOpen, 2021
This study focuses on the development of new synthetic pathways to monosubstituted biguanides from amines. An exhaustive comparison of the conditions and reagents used for biamidine transfer was performed.
Rostyslav Bardovskyi, Marie Fabre, Cyril Ronco, Rachid Benhida   +3 more
doaj   +1 more source

Comparative effectiveness of biguanides versus SGLT2 inhibitors on cardiovascular and cerebrovascular events, diabetic nephropathy, retinopathy, neuropathy, and treatment expenditures in patients with type 2 diabetes. [PDF]

PLoS One
BackgroundSodium-glucose cotransporter-2 (SGLT2) inhibitors are increasingly recommended as first-line treatment for type 2 diabetes mellitus (T2DM), but head-to-head data comparing them with metformin, the canonical biguanide, remain sparse in Japan ...
Nakatani E, Ohno H, Nagahama T, Tonoike T, Yui H, Satoh T, Matsunaga T, Funaki D, Ueki C, Ohata E, Miyakoshi A, Igarashi A, Tanaka Y, Kaneda H, Kumamaru H, Sugawara A.   +15 more
europepmc   +2 more sources

Polyhexamethylene biguanide promotes adaptive cross-resistance to gentamicin in Escherichia coli biofilms

Frontiers in Cellular and Infection Microbiology, 2023
Antimicrobial resistance is a critical public health issue that requires a thorough understanding of the factors that influence the selection and spread of antibiotic-resistant bacteria.
Raphaël Charron, Raphaël Charron, Pierre Lemée, Antoine Huguet, Ornella Minlong, Marine Boulanger, Paméla Houée, Christophe Soumet, Romain Briandet, Arnaud Bridier   +9 more
doaj   +1 more source