Results 21 to 30 of about 20,567 (248)

Synthesis of antibacterial polyether biguanide curing agent and its cured antibacterial epoxy resin

Designed Monomers and Polymers, 2021
At present, bacteria continue to threaten human health, and the resistance of bacteria to antibiotics continues to increase, so the development of new antibacterial agents and antibacterial materials is increasingly important to ensure human health.
Rui Li, Guoxing Yang, Yudan Wang, Lijia Liu, Qiang Wang, Guan Wang, Xiao Ouyang   +6 more
doaj   +1 more source

Synthesis, Characterization and Structural Analysis of Two New Biguanide Complexes

Crystals, 2023
This study reports on the synthesis and characterization of two new coordination compounds of the active pharmaceutical ingredient metformin and transition metals.
Andrea Pastrana-Dávila, Gianella Minotta, Javier Ellena, Pedro H. O. Santiago, Richard F. D’Vries   +4 more
doaj   +1 more source

Repurposing Metabolic Inhibitors in the Treatment of Colon Adenocarcinoma Patient-Derived Models

Cells, 2023
The effect of agonists on AMP-activated protein kinase (AMPK), mainly metformin and phenformin, has been appreciated in the treatment of multiple types of tumors.
Bora Lee, ChuHee Lee, Hae-Min Moon, Se-Young Jo, Se Jin Jang, Young-Ah Suh   +5 more
doaj   +1 more source

Synthetic accesses to biguanide compounds

Beilstein Journal of Organic Chemistry, 2021
Biguanide is a unique chemical function, which has attracted much attention a century ago and is showing resurgent interest in recent years after a long period of dormancy.
Oleksandr Grytsai, Cyril Ronco, Rachid Benhida   +2 more
doaj   +1 more source

A novel biguanide-derivative promotes NEDD4-mediated FGFR1 ubiquitination through BMI1 to overcome osimertinib resistance in NSCLC. [PDF]

Cancer Biol Med
Objective: Osimertinib (OSI) therapy, a cornerstone in treating non-small cell lung cancer (NSCLC), has been severely limited by rapidly developing acquired resistance.
Peng M, Wang W, Xiao D, Li D, Deng J, Zou H, Feng X, Yang Y, Fan S, Yang X.   +9 more
europepmc   +2 more sources

Novel Sulfonamide-Based Analogs of Metformin Exert Promising Anti-Coagulant Effects without Compromising Glucose-Lowering Activity

Pharmaceuticals, 2020
Metformin, one of the most frequently prescribed oral anti-diabetic drugs, is characterized by multidirectional activity, including lipid lowering, cardio-protective and anti-inflammatory properties. This study presents synthesis and stability studies of
Magdalena Markowicz-Piasecka, Adrianna Sadkowska, Joanna Sikora, Marlena Broncel, Kristiina M. Huttunen   +4 more
doaj   +1 more source

Repurposed Biguanide Drugs in Glioblastoma Exert Antiproliferative Effects via the Inhibition of Intracellular Chloride Channel 1 Activity

Frontiers in Oncology, 2019
The lack of in-depth knowledge about the molecular determinants of glioblastoma (GBM) occurrence and progression, combined with few effective and BBB crossing-targeted compounds represents a major challenge for the discovery of novel and efficacious ...
Federica Barbieri, Ivan Verduci, Valentina Carlini, Gianluigi Zona, Gianluigi Zona, Aldo Pagano, Aldo Pagano, Michele Mazzanti, Tullio Florio, Tullio Florio   +9 more
doaj   +1 more source

The Effect of Metformin as an Adjunct Therapy in Adolescents with Type 1 Diabetes [PDF]

Journal of Clinical and Diagnostic Research, 2017
Introduction: The strict control of blood glucose levels in adolescents with Type 1 Diabetes Mellitus (T1DM) is accompanied with a considerable long term decrease in microvasular and macrovascular complications.
Aria Setoodeh, Abdollah Didban, Ali Rabbani, Azadeh Sayarifard, Farzaneh Abbasi, Fatemeh Sayarifard, Fatemeh Hoseinzade   +6 more
doaj   +1 more source

Mono- and Dinuclear Aluminium Complexes Derived from Biguanide and Carbothiamide Ligands

Inorganics, 2021
Dianionic N,N-chelating ligands play a crucial role in coordination chemistry, but reports on related complexes remain limited to certain types of ligands.
Maximilian Dehmel, Helmar Görls, Robert Kretschmer   +2 more
doaj   +1 more source

Sterilized Polyhexanide-Releasing Chitosan Membranes with Potential for Use in Antimicrobial Wound Dressings

Membranes, 2023
Wound infection is a common complication of chronic wounds. It can impair healing, which may not occur without external help. Antimicrobial dressings (AMDs) are a type of external help to infected chronic wounds.
Luís M. Vaz, Rita Branco, Paula V. Morais, António Jorge Guiomar   +3 more
doaj   +1 more source