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Environmental Fate of Polyhexamethylene Biguanide

Bulletin of Environmental Contamination and Toxicology, 2011
Polyhexamethylene biguanide (PHMB) is used as a bacteriocidal agent in a variety of applications from medical devices to pools, but is highly toxic to some aquatic species. The stability of PHMB in various environmental matrices was examined. 80% of PHMB was present in fortified creek samples after 20 days, but bound immediately to soils with the ...
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Clinical Pharmacology of Biguanides

1996
The biguanide drugs have been used to treat hyperglycaemia in non-insulin-dependent diabetes mellitus (NIDDM) for almost 40 years (Sterne 1969; Hermann 1979; Schafer 1983; Bailey 1992). Repeated reports of phenformin-associated lactic acidosis led to the withdrawal of this biguanide in the United States in 1977 and in most other countries.
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Silver(III) biguanides

Journal of the Chemical Society A: Inorganic, Physical, Theoretical, 1969
A series of quadricovalent cationic complexes of silver(III) with biguanide and with methylbiguanide having the composition [AgIIIL2]X3, where L is a bidentate ligand and X a univalent anion, has been prepared and characterised. In alkaline, neutral, and feebly acidic medium (pH > 5), the biguanide molecule possesses filled π-type delocalised orbitals.
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Polyhexamethylene biguanide displays similar mechanism of action to anti-diabetes biguanides