Results 131 to 140 of about 22,636 (317)

Effects of biguanides on oxidative phosphorylation [PDF]

open access: yesCancer & Metabolism, 2014
Metformin, and the related biguanides buformin and phenformin, have been proposed to act by inhibiting respiratory complex I, causing the cellular energetic stress that activates AMP-kinase and initiates a multitude of cell-lineage-specific effects, including inhibition of gluconeogenesis in hepatocytes.
openaire   +2 more sources

Comparison of Antioxidative Effects of Biguanides and Sulfonylureas Monotherapy on Total Antioxidant Status in Newly-Diagnosed Patients with Type 2 Diabetes Mellitus

open access: yes, 2016
Objective: The objective of this study was to compare total antioxidant status (TAS) in type 2 diabetic patients treated with Biguanides monotherapy and Sulfonylureas monotherapy in a tertiary health care center.
S. Mah   +7 more
semanticscholar   +1 more source

Harnessing the Therapeutic Potential of Cell Secretomes and Extracellular Vesicles for Craniofacial Regenerative Applications

open access: yesJournal of Periodontal Research, EarlyView.
The scoping review summarizes the current preclinical and clinical evidence for the use of “cell‐free” therapies in craniofacial (periodontal, bone and soft‐tissue) regeneration. It also aims to highlight key challenges and strategies towards the clinical translation of these therapies.
Siddharth Shanbhag   +6 more
wiley   +1 more source

Biguanides Induce Acute de novo Lipogenesis in Human Primary Sebocytes

open access: yesClinical, Cosmetic and Investigational Dermatology, 2020
James Nicoll, Benjamin M Buehrer Zen-Bio, Inc., Research Triangle Park, NC, USACorrespondence: Benjamin M BuehrerZen-Bio, Inc., 3200 East Highway 54, Suite 100, PO Box 13888, Research Triangle Park, NC 27709, USATel +1 919 547 0692Fax +1 919 547 ...
Nicoll J, Buehrer BM
doaj  

Metformin and its sulphonamide derivative simultaneously potentiateanti-cholinesterase activity of donepezil and inhibit beta-amyloid aggregation

open access: yesJournal of Enzyme Inhibition and Medicinal Chemistry, 2018
The aim of this study was to assess in vitro the effects of sulphenamide and sulphonamide derivatives of metformin on the activity of human acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE), establish the type of inhibition, and assess the ...
Magdalena Markowicz-Piasecka   +2 more
doaj   +1 more source

Multiple Oozing Facial Eruption in a Child Caused by Antiseptics

open access: yes
Contact Dermatitis, EarlyView.
Magalie Coco‐Viloin   +2 more
wiley   +1 more source

Engineered surface strategies to manage dental implant‐related infections

open access: yesPeriodontology 2000, EarlyView.
Abstract When exposed to the oral environment, dental implants, like natural surfaces, become substrates for microbial adhesion and accumulation, often leading to implant‐related infections—one of the main causes of implant failure. These failures impose significant costs on patients, clinicians, and healthcare systems.
João Gabriel S. Souza   +7 more
wiley   +1 more source

Serine deprivation enhances antineoplastic activity of biguanides.

open access: yesCancer Research, 2014
Metformin, a biguanide widely used in the treatment of type II diabetes, clearly exhibits antineoplastic activity in experimental models and has been reported to reduce cancer incidence in diabetics.
Simon-Pierre Gravel   +9 more
semanticscholar   +1 more source

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