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Special Issue: Molecular and Cellular Mechanisms of Cardiovascular Diseases. [PDF]
BiomedicinesGaleone A, Brunetti G.
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Biguanides1 in some form have been used since medieval times. French lilac, or goat’s rue (galega officinalis), was used as a folk treatment for diabetes in southern and eastern Europe. Later, galega officinalis was found to be rich in the compound guanidine. In 1918, the hypoglycemic activity of guanidine was confirmed.
Peggy Soule Odegard +2 more
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Peggy Soule Odegard +2 more
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Antidiabetic Behavior of Biguanides
Journal of Pharmaceutical Sciences, 1983The existence of active electron pairs on some nitrogen atoms in phenformin hydrochloride is inferred from the presence of a hydrogen catalytic polarographic wave. This finding emphasizes the ability of biguanides to form hydrogen bridges with other molecular species such as amino acids and proteins, as well as to form coordination complexes with zinc ...
F, Vicente-Pedrós +2 more
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Nihon rinsho. Japanese journal of clinical medicine, 2015
Metformin, a biguanide, is considered in EASD and ADA to be a first-line glucose-lowering agent for patients with type 2 diabetes. The effectiveness of metformin as an anti-diabetic drug is explained by its ability to lower blood glucose by decreasing hepatic glucose production, stimulating glucose uptake in the muscle, and increasing fatty acid ...
Akio, Ohta, Yasushi, Tanaka
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Metformin, a biguanide, is considered in EASD and ADA to be a first-line glucose-lowering agent for patients with type 2 diabetes. The effectiveness of metformin as an anti-diabetic drug is explained by its ability to lower blood glucose by decreasing hepatic glucose production, stimulating glucose uptake in the muscle, and increasing fatty acid ...
Akio, Ohta, Yasushi, Tanaka
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Diabetes Care, 1992
The main biguanides, metformin and phenformin, were introduced in 1957 as oral glucose-lowering agents to treat non-insulin-dependent diabetes mellitus (NIDDM). Phenformin was withdrawn in many countries because of an association with lactic acidosis, but metformin does not have the same risk if appropriately prescribed. Metformin is now widely used as
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The main biguanides, metformin and phenformin, were introduced in 1957 as oral glucose-lowering agents to treat non-insulin-dependent diabetes mellitus (NIDDM). Phenformin was withdrawn in many countries because of an association with lactic acidosis, but metformin does not have the same risk if appropriately prescribed. Metformin is now widely used as
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Drug and therapeutics bulletin, 1969
The biguanides phenformin (Dibotin - Bayer) and metformin (Glucophage - Rona) have been used in the treatment of diabetes for about 10 years. Continuing experience and many new observations have gradually led to changes in their clinical use.
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The biguanides phenformin (Dibotin - Bayer) and metformin (Glucophage - Rona) have been used in the treatment of diabetes for about 10 years. Continuing experience and many new observations have gradually led to changes in their clinical use.
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Drug and Therapeutics Bulletin, 1964
The article on acetohexamide (May 15, p. 40) mentioned phenformin in passing. We should have made it clear that our remarks about phenformin apply equally to metformin (Glucophage - Rona), the other biguanide available in this country.
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The article on acetohexamide (May 15, p. 40) mentioned phenformin in passing. We should have made it clear that our remarks about phenformin apply equally to metformin (Glucophage - Rona), the other biguanide available in this country.
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Spectrophotometric (UV) investigation on biguanide and substituted biguanides
Tetrahedron, 1972Abstract Biguanide base and its monosalts have absorption maxima at 230 mμ which has been attributed to π-π* transition. The spectral effect on replacement of a carbon π centre by a heteroatom nitrogen centre is discussed and attempt has been made to predict the spectral shifts in biguanide base and normal salts due to the substitution heteronitrogen
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Nihon rinsho. Japanese journal of clinical medicine, 2011
Tomono, Takahashi, Masato, Odawara
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Tomono, Takahashi, Masato, Odawara
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Nihon rinsho. Japanese journal of clinical medicine, 2007
Takanori, Suzuki +3 more
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Takanori, Suzuki +3 more
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