Results 11 to 20 of about 989 (143)

Elucidation of Inverse Agonist Activity of Bilastine

Pharmaceutics, 2020
H1-antihistamines antagonize histamine and prevent it from binding to the histamine H1 receptor (H1R). Some of them also act as inverse agonists, which are more potent than pure antagonists because they suppress the constitutive H1R activity.
Hiroyuki Mizuguchi, Tomoharu Wakugawa, Hisato Sadakata, Seiichiro Kamimura, Mai Takemoto, Tomomi Nakagawa, Masami Yabumoto, Yoshiaki Kitamura, Noriaki Takeda, Hiroyuki Fukui   +9 more
doaj   +2 more sources

Modulation of Bilastine Crystallinity for Enhanced Dissolution and Oral Bioavailability [PDF]

Pharmaceutical Sciences
Background: Bilastine is a second-generation antihistamine belonging to poorly soluble, highly permeable drug class. This resulted in low and variable oral bioavailability. Being antihistaminic, its combination with caffeine is possible. Accordingly, the
Zeinab M. Elrefaey, Rania K. Eid, Mona F. Arafa, Mohamed Nasr, Gamal M. El Maghraby   +4 more
doaj   +2 more sources

UV SPECTROPHOTOMETRIC METHOD FOR QUANTITATIVE DETERMINATION OF BILASTINE USING EXPERIMENTAL DESIGN FOR ROBUSTNESS [PDF]

Drug Analytical Research, 2017
Bilastine is a novel nonsedative H1-receptor antagonist, which may be used for the symptomatic treatment of chronic idiopathic urticaria (CU). This study describes the validation of an UV spectrophotometric method for quantitative determination of ...
Andressa Tassinari da Silva, Gabriela Rossi Brabo, Isadora Dias Marques, Lisiane Bajerski, Marcelo Donadel Malesuik, Clésio Soldateli Paim   +5 more
doaj   +10 more sources

Design, Optimization and Characterization of Self-Nanoemulsifying Drug Delivery Systems of Bilastine [PDF]

Iraqi Journal of Pharmaceutical Sciences, 2023
          Self-nanoemulsifying drug delivery systems are innovative methods that have the potential to resolve a variety of drug formulation issues, including solubility, stability and bioavailability.
Ishraq Kadhim Abbas, Shaimaa Nazar Abd-AlHammid   +1 more
doaj   +2 more sources

Expert opinion on the role of bilastine and bilastine-montelukast combination in the management of allergic rhinitis: An Indian perspective

The Journal of Association of Chest Physicians, 2023
In India, the burden of allergic rhinitis (AR) is enormous, comprising 55% of all patients with allergies. Intranasal corticosteroids are the recommended first-line therapy for patients with moderate-to-severe AR, particularly when nasal congestion is ...
Subir Jain, Sarika Verma, Santhalingam Balamurugan, K.R. Bharath Kumar Reddy, D.J. Christopher   +4 more
doaj   +2 more sources

Bilastine in allergic rhinoconjunctivitis and urticaria: a practical approach to treatment decisions based on queries received by the medical information department

Drugs in Context, 2017
Background: Bilastine is a safe and effective commonly prescribed non-sedating H1-antihistamine approved for symptomatic treatment in patients with allergic disorders such as rhinoconjunctivitis and urticaria. It was evaluated in many patients throughout
Amalia Leceta, Ander Sologuren, Román Valiente, Cristina Campo, Luis Labeaga   +4 more
doaj   +2 more sources

Comparative study of efficacy and safety of cetirizine and bilastine in patients of chronic spontaneous urticaria: Open-label, randomized, parallel-group study

Perspectives in Clinical Research, 2023
Purpose: Bilastine is a novel second-generation antihistaminic. Very few studies in Indian population have compared the safety and efficacy of bilastine with other second-generation antihistaminic like cetirizine.
Vishakha V Sinha, Mrunalini Vinay Kalikar, Jayesh Ishwardas Mukhi, Akhil Bhagwan Giradkar, Smita Sontakke   +4 more
doaj   +2 more sources

Photodegradation kinetics of Bilastine in tablets [PDF]

Drug Analytical Research
Photodegradation is the process by which a chemical substance is broken down through exposure to light, typically ultraviolet (UV) radiation. This process is significant in environmental chemistry, where sunlight can degrade pollutants and materials ...
Ariele Nunes Machado, Jéssica Resch Erd, Andressa Tassinari da Silva, Gabriela Rossi Brabo, José Luiz Ribeiro Portela, Lisiane Bajerski, Clésio soldateli Paim   +6 more
doaj   +7 more sources

Bilastine for the treatment of allergic rhinoconjunctivitis and urticaria: results from an international Delphi study [PDF]

Drugs in Context
Background: Second-generation oral H1-antihistamines, including bilastine, represent the emerging treatments of allergic rhinitis (including rhinoconjunctivitis) and chronic urticaria in both adults and children.
Giorgio Walter Canonica, Piotr Kuna, Marcus Maurer, Ralph Mösges, Zoltan Novak, Nikolaus Papadopoulos, Pablo Rodriguez del Rio, the Delphi Study Group   +7 more
doaj   +2 more sources

Safety and Tolerability of Bilastine 0.6% Ophthalmic Solution: An 8-Weeks Phase III Study

Clinical Ophthalmology, 2023
Piotr Kuna,1 Marek Jutel,2,3 Grazyna Pulka,4 Slawomir Tokarski,5 Paula Arranz,6 Gonzalo Hernández,6 Nieves Fernández Hernando6 1Department of Internal Medicine, Asthma and Allergy, Medical University of Lodz, Lodz, Poland; 2Department of Clinical ...
Kuna P, Jutel M, Pulka G, Tokarski S, Arranz P, Hernández G, Fernández Hernando N   +6 more
doaj   +2 more sources