Results 51 to 60 of about 694 (158)

Sleep Architecture Alterations Following High‐Dose Steroid Pulse Therapy: A Pilot Study Using a Portable Electroencephalogram‐Based Device

Neuropsychopharmacology Reports, Volume 45, Issue 4, December 2025.
High‐dose steroid pulse therapy markedly reduces total sleep time, REM, and NREM sleep, as objectively demonstrated for the first time using a portable EEG‐based device. ABSTRACT Background Sleep disturbance is a common side effect of high‐dose steroid pulse therapy (SPT).
Hiroki Endo, Yuki Shigetsura, Misaki Chahara, Keisuke Kido, Etsuro Nakanishi, Sakiho Ueda, Kimitoshi Kimura, Akira Kuzuya, Hirotsugu Kawashima, Riki Matsumoto, Masahiro Tsuda, Shunsaku Nakagawa, Tomohiro Terada   +12 more
wiley   +1 more source

Development of a green synchronous spectrofluorimetric technique for simultaneous determination of Montelukast sodium and Bilastine in pharmaceutical formulations

BMC Chemistry
For the treatment of rhinitis and asthma, a combination of Montelukast sodium and Bilastine has just been approved. Based on the first derivative of synchronous fluorescence, the current work developed a green, highly accurate, sensitive, and selective ...
Sayed M. Derayea, Khalid M. Badr El-Din, Ahmed S. Ahmed, Ahmed A. Khorshed, Mohamed Oraby   +4 more
doaj   +1 more source

CT‐P39 Compared With Reference Omalizumab in Chronic Spontaneous Urticaria: Results From a Double‐Blind, Randomized, Active‐Controlled, Phase 3 Study

Allergy, Volume 80, Issue 8, Page 2167-2177, August 2025.
This study investigated the therapeutic equivalence of CT‐P39 (an omalizumab biosimilar) and EU‐approved reference omalizumab (ref‐OMA) in patients with chronic spontaneous urticaria. Therapeutic equivalence between CT‐P39 and ref‑OMA (300 mg) was demonstrated by the primary endpoint – confidence intervals of the treatment difference in mean change ...
Sarbjit S. Saini, Marcus Maurer, Yevgeniya Dytyatkovska, Ewa Springer, Maria Ratkova, Borislava Krusheva, Chun Wook Park, Grazyna Pulka, Marta Chełmińska, Adam Reich, Sunghyun Kim, Keumyoung Ahn, Suyoung Kim, Sewon Lee, Jieun Ka, Jongho Kim, Clive Grattan   +16 more
wiley   +1 more source

Sleep Disturbance and Chronic Urticaria: A Narrative Review of Its Relationship, Treatment and Evolving Literature

Health Science Reports, Volume 8, Issue 5, May 2025.
ABSTRACT Background and Aims Chronic Spontaneous Urticaria is characterized by the sudden onset of itchy wheals and angioedema and is primarily driven by mast cells. It can have a significant impact on the Quality of Life (QoL) of an individual. While the role of mast cells in urticaria is extensively described, the link between sleep disorders and ...
Asad Ullah Wasim, Sri Anugna Miriyala, Raymond Haward, Zeinab Hammoud, Pratik Agarwal, Nirja Kaka, Neil Patel, Yashendra Sethi, Poonam Gupta   +8 more
wiley   +1 more source

The Response of Patients' Immune System After Facial Mesotherapy

Journal of Cosmetic Dermatology, Volume 24, Issue 2, February 2025.
ABSTRACT Background Facial mesotherapy is a minimally invasive cosmetic procedure involving the injection of active substances into the dermis and subcutaneous tissue. Although generally considered safe, complications such as granulomatous inflammation can arise due to improper techniques or unregulated products.
Olga Bobowska‐Guglas, Michał Chalcarz, Beniamin Oskar Grabarek, Tomasz Sirek, Jakub Żurawski   +4 more
wiley   +1 more source

Bilastine Based Drugs as SARS-CoV-2 Protease Inhibitors: Molecular Docking, Dynamics, and ADMET Related Studies

Orbital: The Electronic Journal of Chemistry, 2022
Bilastine drugs, structurally piperidine-1-carboxylate and sulfonyloxyethyl carboxylate derivatives, have significantly been employed as the medication of second-generation antihistamine drugs, and are used for the treatment of allergic ...
Ajoy Kumer, Unesco Chakma, Mohammed M. Matin   +2 more
doaj  

Allergic rhinitis: are there any problems? Case from clinical practice

Медицинский совет, 2020
Allergic rhinitis (AR) is found in the practice of doctors of various specialties, but making the correct diagnosis and prescribing adequate therapy can take many months and sometimes years.
O. V. Sebekina, E. V. Peredkova, N. M. Nenasheva   +2 more
doaj   +1 more source

The translational value of ligand‐receptor binding kinetics in drug discovery

British Journal of Pharmacology, Volume 181, Issue 21, Page 4117-4129, November 2024.
Abstract The translation of in vitro potency of a candidate drug, as determined by traditional pharmacology metrics (such as EC50/IC50 and KD/Ki values), to in vivo efficacy and safety is challenging. Residence time, which represents the duration of drug‐target interaction, can be part of a more comprehensive understanding of the dynamic nature of drug‐
Hongli Liu, Haoran Zhang, Adriaan P. IJzerman, Dong Guo   +3 more
wiley   +1 more source

Efficacy of switching to bilastine, a histamine H1 receptor antagonist, in patients with chronic spontaneous urticaria (H1-SWITCH): study protocol for a randomized controlled trial

Trials, 2020
Background Chronic spontaneous urticaria (CSU) is characterized by the spontaneous appearance of wheals, angioedema, or both for > 6 weeks. Continuous treatment with H1-antihistamines is used as a first-line treatment for CSU.
Atsushi Fukunaga, Yoshiko Oda, Ken Washio, Takashi Omori, Yasumasa Kakei, Michihiro Hide, Chikako Nishigori   +6 more
doaj   +1 more source

Drugs associated with epidermal necrolysis in children: A World Health Organization pharmacovigilance database analysis

Journal of the European Academy of Dermatology and Venereology, Volume 38, Issue 9, Page 1791-1798, September 2024.
Abstract Background Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare life‐threatening mucocutaneous reactions most often induced by drugs. To date, no large pharmacovigilance study has been conducted in the paediatric population.
Pauline Bataille, Benedicte Lebrun‐Vignes, Thomas Bettuzzi, Saskia Ingen‐Housz‐Oro, Smail Hadj‐Rabia, Anne Welfringer‐Morin, Christine Bodemer   +6 more
wiley   +1 more source