Results 41 to 50 of about 3,593,458 (250)

ROS Self‐Supply Nanoplatform Based on Fenton Catalyst for Chemodynamic and Immunotherapy: Reprogramming Cold Tumor Into Hot Tumor in Cancer Treatment

Advanced Science, EarlyView.
A multifunctional HA‐conjugated nanoplatform (HA‐PGMC) integrates CuO2, glucose oxidase, and mil‐100 to enable cascade catalytic ROS generation in tumor microenvironments. This self‐supplying ROS strategy induces immunogenic cell death, reprograms “cold” tumors into “hot” ones, and synergizes with PD‐L1 blockade, achieving potent chemodynamic ...
Man Lung Lee, Jack Chun Hin Chen, Wai Wing Cheng, Kwan Yee Lau, Hiu Yee Kwan, Ngar‐Yun Ellen Poon, Hung‐Wing Li   +6 more
wiley   +1 more source

Estimating causal effects of genetic risk variants for breast cancer using marker data from bilateral and familial cases. [PDF]

, 2011
BACKGROUND: Cases with a family history are enriched for genetic risk variants, and the power of association studies can be improved by selecting cases with a family history of disease.
Johnson, Nichola, Orr, Nick, Fletcher, Olivia, Walker, Kate, Dudbridge, Frank, Dos Santos Silva, Isabel, Peto, Julian, Orr, Nick; id_orcid   +7 more
core   +1 more source

Clinical Features of Breast Cancer in South Korean Patients with Germline TP53 Gene Mutations [PDF]

, 2021
Purpose: Li-Fraumeni syndrome (LFS) is a rare autosomal cancer syndrome caused by a germline mutation in the TP53 gene. Breast cancer in LFS patients is of various subtypes; however, limited data are available on the clinicopathological features of these
정준, 배숭준
core   +1 more source

Black Hole Quencher‐Enhanced Plasmonic Photothermal Conversion

Advanced Science, EarlyView.
Researchers have developed a universal method to boost plasmonic photothermal conversion by attaching black hole quencher (BHQ) molecules to matched metal nanostructures. This hybrid approach increases efficiency by roughly threefold, reaching up to 69.1% in the near‐infrared‐II window.
Ruiyuan Zhang, Xinru Chen, Lin Shen, Jin Li   +3 more
wiley   +1 more source

ALDH Inhibition‐Primed Photocatalysis Disrupts Cancer Stemness Plasticity

Angewandte Chemie, EarlyView.
DE‐Et converts ALDH‐mediated redox buffering into a photoredox vulnerability by coupling ALDH inhibition with red‐light‐driven catalytic NADH oxidation. This enzyme‐coupled photoredox strategy sustains mitochondrial NADH/NAD+ imbalance, induces pyroptotic tumor cell death, suppresses tumor growth in vivo, and promotes systemic antitumor immunity ...
Yujin Kim, Shankun Yao, Ji Hyeon Kim, Rongrong Huang, Hyeonji Rha, Shumeng Li, Kippeum Lee, Yunjie Xu, Xiaogang Liu, Yuncong Chen, Jong Seung Kim   +10 more
wiley   +2 more sources

Metastatic breast cancer to the thyroid diagnosed by fine-needle aspiration cytology: A case report and literature review

Human Pathology Reports, 2022
Metastatic breast cancer to the thyroid is rare. We report a case of breast cancer that metastasized to bilateral thyroid. A 62-year-old woman who was admitted due to thyroid nodules identified by ultrasound.
Zhaohui Yang, Xiaobo Cai, Xuequan Cao, Chengquan Zhao, Hongsheng Lu   +4 more
doaj   +1 more source

ER and HER2 expression are positively correlated in HER2 non-overexpressing breast cancer. [PDF]

, 2012
INTRODUCTION: Estrogen receptor-α (ER) and human epidermal growth factor receptor 2 (HER2) positivity are inversely correlated by standard criteria. However, we investigated the quantitative relation between ER and HER2 expression at both RNA and protein
Yarnold, J, Drury, Suzanne, Barrett-Lee, P, Hills, Margaret, Salter, J, Lawrence, D, Harnett, AM, Cuzick, J, Earl, H, Sestak, I, Ma, NCRIABCT, Georges Sumo, A'Hern, R, Sestak, Ivana, Barrett-Lee, Peter Jeffrey, Dowsett, M, A'Hern, Roger, Robinson, A, Perren, T, Johnson, L, Harris, Adrian, George, WD, Bliss, JM, Dodwell, D, null null, Peter Barrett-Lee, Price, D, Foster, L, Poole, C, Isabel Pinhel, Suzanne Drury, Fernando, I, Dowsett, Mitch, Cuzick, Jack, Judith M Bliss, Barrett-Lee, Peter, Sumo, G, Raina, V, Hills, M, Roger A'Hern, Ivana Sestak, Adrian Harris, Janine Salter, Jack Cuzick, Bliss, Judith M., Brunt, AM, Peto, J, Drury, S, Bliss, Judith M, Sumo, Georges, Margaret Hills, Mitch Dowsett, Pinhel, Isabel, Harris, A, NCRI Adjuvant Breast Cancer Trial Management Group, Bliss, M, Pinhel, I, Salter, Janine   +57 more
core   +2 more sources

Engineering‐Modulated Molybdenum Enzymes Strategy for Tumor‐Specific Metabolic‐Immunotherapy

Advanced Science, EarlyView.
Biodegradable molybdenum sulfide nanoparticles were synthesized via a one‐pot strategy to increase molybdenum enzyme activity and thus effectively potentiate anti‐tumor immunity by integrating molybdenum‐based metalloimmunotherapy with hydrogen sulfide gas therapy.
Xiaoxiao Pan, Zifan Pei, Jie Wu, Nan Jiang, Qian Li, Yuqi Yang, Jie Cao, Yechen Huang, Shumin Sun, Qialu Du, Zhicheng Liu, Lin Zhang, Fei Gong, Jinhua Zhou, Liang Cheng   +14 more
wiley   +1 more source

CLINICAL AND MORPHOLOGICAL CHARACTERISTICS OF BILATERAL BREAST CANCER

Сибирский онкологический журнал, 2016
Background. The paper has been devoted to the study of clinical and morphological features of bilateral breast cancer (BC). Despite the increased interest in the lateral BC, pathogenesis of this type of cancer have been little studied.
М. V. Zavyalova, N. V. Krakhmal, Е. A. Fesik, L. N. Bondar, Е. М. Slonimskaya, S. V. Vtorushin, V. M. Perelmuter, О. Е. Savelyeva   +7 more
doaj  

Lanthanum Carbonate Nanosheets Based Colloidal Hydrogel for Modulating Innate & Adaptive Tumor Immunotherapy by Augmented Cellular Pyroptosis

Advanced Science, EarlyView.
The Gela/decitabine/La2(CO3)3 colloidal (GDLC) hydrogel developed here could reverse the epigenetic silencing of the GSDME gene by the synergistic interaction between DAC and La3+, while concurrently activating caspase‐3, thus facilitating pyroptosis induction under the tumor microenvironment.
Yang Hong, Haitao Wu, Weitao Wang, Xuan Zhang, Qian Chen, Yaoyu Hu, Zhengbao Zha   +6 more
wiley   +1 more source