Results 31 to 40 of about 3,593,458 (250)

Impact of Radiation Therapy on Physical and Psychosocial Health of Adolescents and Young Adults: A Joint Report From the Children's Oncology Group AYA and Radiation Oncology Committees

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Rates of cancer among adolescents and young adults (AYA), age 15–39 years, are increasing. Consequently, radiation oncologists are treating more AYAs who have diagnoses spanning both pediatric and adult practices. Compared to pediatric and older adult patients, AYAs face a unique set of challenges.
Hesham Elhalawani, Rachel K. Peterson, Avani D. Rao, Laurie J. McKenzie, Ahmed Magdy Elmotayam, Leslie Chang, Michael Roth, Susan L. McGovern   +7 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Tumour suppressor EP300, a modulator of paclitaxel resistance and stemness, is down-regulated in metaplastic breast cancer [PDF]

, 2017
Purpose We have previously described a novel pathway controlling drug resistance, epithelial-to-mesenchymal transition (EMT) and stemness in breast cancer cells.
Singh, P, Yague, E, Raguz, S, Ali, S, Lin, ML, Coombes, RC, Asaduzzaman, M, Hu, Y, Gallon, J, Shousha, S, Haoxiang, M, Lam, EWF, Constantinou, S   +12 more
core   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

BAP31 Drives Cartilage Calcification through Disruption of Autophagosome–Lysosome Fusion in Osteoarthritis

Advanced Science, EarlyView.
Mechanical stress activates BAP31 in chondrocytes. BAP31 competes with ATG14 for binding to STX17, disrupting the STX17–ATG14 complex required for autophagosome–lysosome fusion. The resultant autophagic flux blockade drives the generation of autophagy‐derived exosomes, which mediate pathological cartilage calcification in OA. Chondrocyte‐targeted BAP31
Zhi‐hua Xu, Ruo‐xin Wang, Feng He, Qian Liu, Fu‐yin Li, Min Hui, Yu‐qian Shi, Yu Jiang, Qing‐hua Li, Jun‐wen Jing, Shi‐bin Yu, Li‐tian Ma, Qian‐nan Niu, Mian Zhang   +13 more
wiley   +1 more source

Evaluation of healthcare management issues in the provision of clinical services for familial breast/ovarian cancer [PDF]

, 2009
Electronic version does not contain associated previously published materialDespite there being pragmatic national guidelines for assigning risk to women with a family history of breast cancer, the evidence base is still sparse.
de Azevedo Moreira Reis, Marta
core   +2 more sources

Bilateral Primary Breast Cancer With Discordance in Molecular Subtypes: A Case Report

International Journal of Breast Cancer
Molecular subtype is a crucial prognostic factor for bilateral breast cancer and plays a key role in guiding treatment decisions. Several studies have confirmed that the expression patterns of hormone receptor and human epidermal growth factor receptor 2
Yingying Rao, Qian Zhan, Hengyu Li
doaj   +1 more source

ATM variants and cancer risk in breast cancer patients from Southern Finland

BMC Cancer, 2006
Background Individuals heterozygous for germline ATM mutations have been reported to have an increased risk for breast cancer but the role for ATM genetic variants for breast cancer risk has remained unclear.
Aittomäki Kristiina, Tamminen Anitta, Kristensen Vessela, Edvardsen Hege, Kilpivaara Outi, Jansen Laila, Tommiska Johanna, Blomqvist Carl, Børresen-Dale Anne-Lise, Nevanlinna Heli   +9 more
doaj   +1 more source

Bilateral Autologous Breast Reconstruction in a Patient with Unilateral Breast Cancer: A Case Report [PDF]

Archives of Aesthetic Plastic Surgery, 2018
Various reconstructive and/or oncoplastic options are available for breast cancer patients. In properly selected patients, autologous tissue-based reconstruction usually results in aesthetic, natural breasts.
Young Chul Kim, Byung Ho Son, Eun Key Kim   +2 more
doaj   +1 more source

Unusual presentation of a small cell lung cancer with bilateral breast metastases: Case report and a brief review of the literature

Respiratory Medicine Case Reports, 2022
Small cell lung cancer (SCLC) is a smoker's disease and occurs almost exclusively in smokers. SCLC is a high-grade neuroendocrine tumor and commonly presents as a central tumor with bulky mediastinal adenopathy.
Mark Bannon, Creticus Marak, Adrita Ashraf, Chelsea Smith, Matthew Nunley, Achuta Kumar Guddati, Prashant Kaushik   +6 more
doaj   +1 more source