Results 41 to 50 of about 1,013,035 (362)

Bile-volatile organic compounds in the diagnostics of pancreatic cancer and biliary obstruction: A prospective proof-of-concept study

Frontiers in Oncology, 2022
ObjectivesDetection of volatile organic compounds (VOCs) from bodily fluids with field asymmetric waveform ion mobility spectrometry (FAIMS) and related methods has been studied in various settings.
Ville Teränen, Ville Teränen, Samuli Nissinen, Antti Roine, Anne Antila, Antti Siiki, Yrjö Vaalavuo, Pekka Kumpulainen, Niku Oksala, Johanna Laukkarinen, Johanna Laukkarinen   +10 more
doaj   +1 more source

Cholesterol nucleation time in gallbladder bile of patients with solitary or multiple cholesterol gallstones [PDF]

, 1992
Patients with multiple cholesterol gallbladder stones have been found to be at a higher risk for the recurrence of gallstones after successful nonsurgical treatment than those with a solitary stone.
Abell, Admirand, Carey, Carey, Christoph von Ritter, Dieter Jüngst, Ekkehard Pratschke, Fiske, Gollish, Groen, Gustav Paumgartner, Holan, Lanzini, O'Donnel, Pattinson, Pomeranz, Sackmann, Schriever, Sedaghat, Shiffman, Smallwood, Spengler, Talalay, Tera, Thomas Lang, Van Erpecum, Villanova, Whiting   +27 more
core   +1 more source

Generation and validation of a conditional knockout mouse model for desmosterolosis

Journal of Lipid Research, 2021
: The enzyme 3β-hydroxysterol-Δ24 reductase (DHCR24, EC 1.3.1.72) catalyzes the conversion of desmosterol to cholesterol and is obligatory for post-squalene cholesterol synthesis.
Babunageswararao Kanuri, Vincent Fong, Sithara Raju Ponny, Ranjuna Weerasekera, Kirthi Pulakanti, Kriya S. Patel, Roman Tyshynsky, Shailendra B. Patel   +7 more
doaj   +1 more source

Synthesis, in vitro and in vivo evaluation of 3β-[18F]fluorocholic acid for the detection of drug-induced cholestasis in mice [PDF]

, 2017
Introduction : Drug-induced cholestasis is a liver disorder that might be caused by interference of drugs with the hepatobiliary bile acid transporters. It is important to identify this interference early on in drug development.
De Lombaerde, Stef, De Vos, Filip, Devisscher, Lindsey, Kersemans, Ken, Neyt, Sara, Van Vlierberghe, Hans, Vanhove, Christian, Verhoeven, Jeroen   +7 more
core   +3 more sources

Trans-intestinal cholesterol efflux is not mediated through high density lipoprotein

Journal of Lipid Research, 2012
Transintestinal cholesterol efflux (TICE) provides an attractive target to increase body cholesterol excretion. At present, the cholesterol donor responsible for direct delivery of plasma cholesterol to the intestine is unknown.
Carlos L.J. Vrins, Roelof Ottenhoff, Karin van den Oever, Dirk R. de Waart, J. Kar Kruyt, Ying Zhao, Theo J.C. van Berkel, Louis M. Havekes, Johannes M. Aerts, Miranda van Eck, Patrick C.N. Rensen, Albert K. Groen   +11 more
doaj   +1 more source

Intravital Multiphoton Microscopy with Fluorescent Bile Salts in Rats as an In Vivo Biomarker for Hepatobiliary Transport Inhibition [PDF]

, 2018
The bile salt export pump (BSEP) is expressed at the canalicular domain of hepatocytes, where it mediates the elimination of monovalent bile salts into the bile.
Chen, Yuan, Dunn, Kenneth W., Dunn, Robert T., Morgan, Ryan E., Ryan, Jennifer, Volak, Laurie P.   +5 more
core   +1 more source

Physiological concentrations of bile acids down-regulate agonist induced secretion in colonic epithelial cells [PDF]

, 2009
In patients with bile acid malabsorption, high concentrations of bile acids enter the colon and stimulate Cl− and fluid secretion, thereby causing diarrhoea. However, deoxycholic acid (DCA), the predominant colonic bile acid, is normally present at lower
Alan F. Hofmann, Barcelo, Barrett, Bertelsen, Cartwright, Chadwick, Cheng, Cheng, Christine Marsh, Dawson, Dawson, Devor, Dharmsathaphorn, Fernandez-Banares, Gail Ferguson, Gelbmann, Gordon, Hamilton, Hofmann, J-P, Kalia, Keely, Keely, Keely, Khurana, Kok, Kruis, Magdalena S. Mroz, Mauricio, Mekjian, Merchant, Michael M. Scharl, Milovic, Montrose, Muhlbauer, Münch, Niamh Keating, Nyhlin, Potter, Raimondi, Smith, Stephen J. Keely, Teem, Ung, Venkatasubramanian, Weihrauch   +45 more
core   +1 more source

A Panel of Bile Volatile Organic Compounds Servers as a Potential Diagnostic Biomarker for Gallbladder Cancer

Frontiers in Oncology, 2022
As no reliable diagnostic methods are available, gallbladder cancer (GBC) is often diagnosed until advanced stages, resulting in a poor prognosis. In the present study, we assessed whether volatile organic compounds (VOCs) could be used as a diagnostic ...
Xin Zhang, Xinru Gui, Yanli Zhang, Qi Liu, Liqiang Zhao, Jingxian Gao, Jian Ji, Yi Zhang   +7 more
doaj   +1 more source

The microbiota of the bilio-pancreatic system: A cohort, STROBE-compliant study [PDF]

, 2019
Background: The gut microbiota play an essential role in protecting the host against pathogenic microorganisms by modulating immunity and regulating metabolic processes.
Agrusa A., D'arpa F., Di Carlo P., Fasciana T., Giammanco A., Gulotta G., Rodolico V., Sergi C., Serra N.   +8 more
core   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source