Results 131 to 140 of about 5,534,791 (400)

Model of pathogenesis of psoriasis. Part 1. Systemic psoriatic process [PDF]

arXiv, 2011
Analytical study of results of experimental and theoretical works on pathogenesis of psoriatic disease was conducted. Psoriasis is dermal implication of systemic psoriatic process (SPP). New SPP model explaining results of clinical and laboratory experiments was formulated.
arxiv  

Bile Acid Sequestrants for Lipid and Glucose Control [PDF]

, 2010
Bile acids are generated in the liver and are traditionally recognized for their regulatory role in multiple metabolic processes including bile acid homeostasis, nutrient absorption, and cholesterol homeostasis.
A Garg, A Nguyen, B Cariou, B Cariou, B Cariou, B Goodwin, B Staels, Bart Staels, C Thomas, C Thomas, D Duran-Sandoval, D Duran-Sandoval, D Hunninghake, DW Russell, E Andersen, E Tomlinson, G Lambert, H Sato, HE Bays, HH Knapp, HR Kast, I Pineda Torra, K Einarsson, K Ma, K Uchida, M Watanabe, M Watanabe, MH Davidson, P Lefebvre, RB Goldberg, S Bhatnagar, S Katsuma, T Claudel, T Claudel, T Inagaki, T Maruyama, T Maruyama, U Ozcan, VA Fonseca, Vivian Fonseca, W Insull Jr, W Insull Jr, W Insull Jr, Y Kawamata, Y Zhang, Y Zhang, Yehuda Handelsman   +46 more
core   +2 more sources

In vitro and in vivo characterization of Clostridium scindens bile acid transformations

Gut microbes, 2018
The human gut hosts trillions of microorganisms that exert a profound influence on human biology. Gut bacteria communicate with their host by secreting small molecules that can signal to distant organs in the body.
Solenne Marion, Nicolas Studer, L. Desharnais, L. Menin, S. Escrig, A. Meibom, S. Hapfelmeier, R. Bernier-Latmani   +7 more
semanticscholar   +1 more source

Paclitaxel/Luteolin Coloaded Dual‐Functional Liposomes for Esophageal Cancer Therapy

Advanced Science, EarlyView.
The authors develop a pH‐sensitive aptamer‐modified liposome (EA2‐PSL‐PTX/LUT) to illustrate a strategy for the precise delivery of combinational chemotherapeutic drugs for esophageal squamous cell carcinoma (ESCC) targeted therapy. EA2‐PSL‐PTX/LUT provides efficient co‐loading, tumor targeting, and controlled release of luteolin and paclitaxel ...
Congyong Sun, Fei Xie, Huiyun Zhang, Lulu Feng, Yuting Wang, Chaofan Huang, Zhizhen Cui, Chao Luo, Li Zhang, Qilong Wang   +9 more
wiley   +1 more source

Differential modulation of cellular death and survival pathways by conjugated bile acids [PDF]

, 2001
BACKGROUND: The liver-derived McNtcp.24 cells transport bile acids and show distinctive responses to the two classes of conjugated bile acids. Whereas taurine-conjugated bile acids are non-toxic, glycine-conjugated bile acids efficiently induce apoptosis.
Agellon, Luis B, Stolz, Andrew, Torchia, Enrique C   +2 more
core   +3 more sources

Bile Acid Signaling Pathways from the Enterohepatic Circulation to the Central Nervous System

Frontiers in Neuroscience, 2017
Bile acids are best known as detergents involved in the digestion of lipids. In addition, new data in the last decade have shown that bile acids also function as gut hormones capable of influencing metabolic processes via receptors such as FXR (farnesoid
Kim L. Mertens, A. Kalsbeek, M. Soeters, H. Eggink   +3 more
semanticscholar   +1 more source

Gut Microbiota Modulation by Inulin Improves Metabolism and Ovarian Function in Polycystic Ovary Syndrome

Advanced Science, EarlyView.
This work proposes a novel strategy targeting gut microbiota for managing polycystic ovary syndrome (PCOS). Inulin, a gut microbiota modulator, notably boosts the growth of short‐chain fatty acids (SCFAs)‐producers, represented by Bifidobacterium, thereby improving glucolipid metabolism and ovarian function of PCOS through suppressing the inflammatory ...
Lulu Geng, Xin Yang, Jiani Sun, Ximing Ran, Dan Zhou, Mingming Ye, Li Wen, Ruirui Wang, Miaoxin Chen   +8 more
wiley   +1 more source

Ileal bile acid transport regulates bile acid pool, synthesis, and plasma cholesterol levels differently in cholesterol-fed rats and rabbits

Journal of Lipid Research, 2000
We investigated the effect of ileal bile acid transport on the regulation of classic and alternative bile acid synthesis in cholesterol-fed rats and rabbits.
Guorong Xu, Benjamin L. Shneider, Sarah Shefer, Lien B. Nguyen, Ashok K. Batta, G. Stephen Tint, Marco Arrese, Sundararajah Thevananther, Lin Ma, Siegfried Stengelin, Werner Kramer, David Greenblatt, Mark Pcolinsky, Gerald Salen   +13 more
doaj  

An approximate cooperativity analysis by DSC of phase transitions of DPPC-DOCNa dispersions [PDF]

arXiv, 2001
The effect of solute, sodium deoxycholate bile salt (DOCNa), on the cooperativity of ordered-fluid, fosfolipid phase transition has been investigated by determining of the transition widths in multibilayer dispersions of the dipalmitoylphosphatidylcholine (DPPC)-DOCNa mixtures. The DT1/2 values were determined by differential scanning calorimetry.
arxiv  

Bile acid metabolism regulated by the gut microbiota promotes non-alcoholic steatohepatitis-associated hepatocellular carcinoma in mice

OncoTarget, 2018
Gut microbiota plays a significant role in the development of hepatocellular carcinoma (HCC) in non-alcoholic steatohepatitis (NASH). However, understanding of the precise mechanism of this process remains incomplete. A new class steatohepatitis-inducing
S. Yamada, Yoko Takashina, Mitsuhiro Watanabe, Ryogo Nagamine, Yoshimasa Saito, N. Kamada, H. Saito   +6 more
semanticscholar   +1 more source