Results 171 to 180 of about 5,534,791 (400)

Efficacy and safety of switching therapy from chenodeoxycholic acid to cholic acid in Japanese patients with bile acid synthesis disorders

Molecular Genetics and Metabolism Reports
Objectives: This study aimed to assess the safety and efficacy of cholic acid (CA) treatment over 74 weeks in Japanese patients with inherited enzymatic bile acid synthesis disorders (BASD).
Mitsuyoshi Suzuki, Hajime Takei, Hiromi Suzuki, Jun Mori, Satoru Sugimoto, Tatsuki Mizuochi, Akira Ohtake, Hisamitsu Hayashi, Akihiko Kimura, Hiroshi Nittono   +9 more
doaj  

Endoplasmic Reticulum Stress Regulates Hepatic Bile Acid Metabolism in MiceSummary

Cellular and Molecular Gastroenterology and Hepatology, 2017
Background & Aims: Cholestasis promotes endoplasmic reticulum (ER) stress in the liver, however, the effect of ER stress on hepatic bile acid metabolism is unknown.
Anne S. Henkel, Brian LeCuyer, Shantel Olivares, Richard M. Green   +3 more
doaj  

Modeling of the formation of short-chain acids in propane flames [PDF]

arXiv, 2009
In order to better understand their potential formation in combustion systems, a detailed kinetic mechanism for the formation of short-chain monocarboxylic acids, formic (HCOOH), acetic (CH3COOH), propionic (C2H5COOH) and propenic (C2H3COOH)) acids, has been developed. Simulations of lean (equivalence ratios from 0.9 to 0.48) laminar premixed flames of
arxiv  

Global chemical effects of the microbiome include new bile-acid conjugations

Nature, 2020
R. Quinn, A. Melnik, Alison Vrbanac, T. Fu, K. Patras, Mitchell P. Christy, Z. Bodai, P. Belda-Ferre, A. Tripathi, Lawton K. Chung, M. Downes, Ryan D. Welch, M. Quinn, G. Humphrey, Morgan Panitchpakdi, Kelly C. Weldon, A. Aksenov, R. D. da Silva, J. Ávila-Pacheco, C. Clish, Sena Bae, Himel Mallick, PhD, FASA, E. Franzosa, J. Lloyd-Price, R. Bussell, Taren M. Thron, A. T. Nelson, Mingxun Wang, Eric C. Leszczynski, Fernando Vargas, J. Gauglitz, Michael J. Meehan, Emily C. Gentry, Timothy D. Arthur, Alexis C. Komor, Orit Poulsen, B. Boland, John T. Chang, W. Sandborn, M. Lim, Neha Garg, J. Lumeng, R. Xavier, B. Kazmierczak, R. Jain, M. Egan, Kyung E. Rhee, David Ferguson, M. Raffatellu, H. Vlamakis, G. Haddad, D. Siegel, C. Huttenhower, S. Mazmanian, R. Evans, V. Nizet, R. Knight, P. Dorrestein   +57 more
semanticscholar   +1 more source

Identification of Tumor‐Specific Surface Proteins Enables Quantification of Extracellular Vesicle Subtypes for Early Detection of Pancreatic Ductal Adenocarcinoma

Advanced Science, EarlyView.
Pancreatic ductal adenocarcinoma (PDAC) extracellular vesicle (EV) surface protein assay operates via a two‐step workflow – Step 1: Click chemistry‐mediated enrichment of PDAC EVs by EV Click Beads, in the presence of one of the three trans‐cyclooctene‐grafted PDAC EV‐specific antibodies; Step 2: Quantification of the enriched PDAC EVs by reverse ...
Chen Zhao, Zhili Wang, Hyoyong Kim, Hui Kong, Junseok Lee, Jacqueline Ziqian Yang, Anmin Wang, Ryan Y. Zhang, Yong Ju, Jina Kim, Bing Feng, Dejun Liu, Yating Zhang, Zhenfang Wang, Yandong Zhang, Shujing Guo, Dekang Gao, James S. Tomlinson, Renjun Pei, Jipeng Wan, Stephen J. Pandol, Myung‐Shin Sim, Sungyong You, Ding Ma, Shaohua Lu, Na Sun, Hsian‐Rong Tseng, Yazhen Zhu   +27 more
wiley   +1 more source

Inhibition of canalicular and sinusoidal taurocholate efflux by cholestatic drugs in human hepatoma HepaRG cells

Biopharmaceutics &Drug Disposition, Volume 43, Issue 6, Page 265-271, December 2022., 2022
Effects of cholestatic drugs towards hepatic canalicular and sinusoidal secretion of bile acids were investigated using a biphasic functional assay in human hepatoma HepaRG cells. After an initial loading phase with taurocholate, cells were re‐incubated in taurocholate‐free medium (efflux phase), with or without calcium (for modulating the opening of ...
Marc Le Vée, Amélie Moreau, Elodie Jouan, Claire Denizot, Yannick Parmentier, Olivier Fardel   +5 more
wiley   +1 more source

An N-acyl glycyltaurine conjugate of deoxycholic acid in the biliary bile acids of the rabbit

Journal of Lipid Research, 1998
The biliary bile acid composition of the adult and neonatal domestic rabbit, as well as that of the adult brush rabbit, was characterized. In adult domestic rabbits, the dominant bile acid present was deoxycholic acid (88“% of total bile acids), a ...
Lee R. Hagey, Claudio D. Schteingart, Steven S. Rossi, H-T. Ton-Nu, Alan F. Hofmann   +4 more
doaj  

Occurrence and Metabolism of Chenodeoxycholic Acid in the Rat. Bile Acids and Steroids. 13. [PDF]

, 1954
Sune Bergström, Jan Sjövall, Roger Bonnichsen, John Rastrup Andersen   +3 more
openalex   +1 more source

The ulcerogenic effect of bile and bile acid in rats during immobilization stress [PDF]

The effect of different concentrations of oxen bile and individual bile acids or their sodium salts on the gastric mucosa of rats was investigated in combination with immobilization stress.
Weisener, J.
core   +1 more source

Diallyl Trisulfide From Garlic Regulates RAB18 Phase Separation to Inhibit Lipophagy and Induce Cuproptosis in Hepatic Stellate Cells for Antifibrotic Effects

Advanced Science, EarlyView.
Diallyl trisulfides (DATs) selectively induce cuproptosis in hepatic stellate cells (HSCs) by targeting Ras‐related protein Rab‐18 (RAB18) and regulating lipophagy. DATs promote RAB18 phase separation, enhance mitochondrial‐associated membrane structures (MAMs) formation, and increase succinylation of dihydrolipoamide dehydrogenase (DLD) at K320.
Haoyuan Tian, Shujiang Sun, Xinran Qiu, Junrui Wang, Yuanyuan Gao, Jianmei Chen, Xiang Han, Zhengyang Bao, Xiaohan Guo, Yuqi Sun, Yuxin Lin, Mengru Hu, Feng Zhang, Zili Zhang, Feixia Wang, Shizhong Zheng, Jiangjuan Shao   +16 more
wiley   +1 more source